DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Tie1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_035717.2 Gene:Tie1 / 21846 MGIID:99906 Length:1134 Species:Mus musculus


Alignment Length:701 Identity:205/701 - (29%)
Similarity:299/701 - (42%) Gaps:200/701 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PSGSLLTLNCHALGNPEPNI-----TWYRNG----TVDWT------RGYGSLKRNRW-------- 157
            || :|:|.:|     |||.:     :|:..|    .|.|:      .|.|.|.| .|        
Mouse   532 PS-ALMTTDC-----PEPLLQPWLESWHVEGPDRLRVSWSLPSVPLSGDGFLLR-LWDGARGQER 589

  Fly   158 ----------TLTMEDLVPGDCGNYTCKV----CNSLG----------------CIRH-DTQVIV 191
                      |..:..|.||.  :|...|    |..||                ..|| ..|.:.
Mouse   590 RENISFPQARTALLTGLTPGT--HYQLDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALS 652

  Fly   192 SDRVN---HKPILMTGPLNLTLVVNSTGSMHCKYLSDL-----TSKKAWIFVPCHGMTNCSNNRS 248
            ...:.   ..|...:||::             ||:.::     :....|:.|      :.....|
Mouse   653 DSEIQLMWQHPEAPSGPIS-------------KYIVEIQVAGGSGDPQWMDV------DRPEETS 698

  Fly   249 IIAE--DKDQLDFVNVRMEQEG---WYTCVESNSLG---QSNSTAYLRVVRSLHVLEAGV----- 300
            ||..  :........||...:|   |...||..:||   ||...     ||.....|.|:     
Mouse   699 IIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGP-----VRESRAAEEGLDQQLV 758

  Fly   301 --ASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363
              ..||:.:|...           .:..|.....||:    ..|.:|....:|          .|
Mouse   759 LAVVGSVSATCLT-----------ILAALLALVCIRR----SCLHRRRTFTYQ----------SG 798

  Fly   364 GGD------SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422
            .|:      |||::              |...:...:|.|.:   :|: ..||    .:.....:
Mouse   799 SGEETILQFSSGTL--------------TLTRRPKPQPEPLS---YPV-LEWE----DITFEDLI 841

  Fly   423 GEGAFGRVVMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS 481
            |||.||:|:.|.:.      ||  |:||:||..:::|......|:||:..:|.|.|||||||.|.
Mouse   842 GEGNFGQVIRAMIKKDGLKMNA--AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACE 904

  Fly   482 QNGPLYVIVEYAPHGNLKDFLYKNR------PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQI 540
            ..|.||:.:||||:|||.|||.|:|      .|.|:..          .|..::.:.|::||...
Mouse   905 NRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHG----------TASTLSSRQLLRFASDA 959

  Fly   541 ARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESL 605
            |.||.||:.::.||||||||||||.::...|||||||:|   ..:.|.|.|.||||::|||.|||
Mouse   960 ANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESL 1021

  Fly   606 QEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQC 670
            ....|.:||||||:|:|||||::.|..|| ..|:..|||..|..|.|||:|..|...:|.|||||
Mouse  1022 NYSVYTTKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC 1085

  Fly   671 WHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLDTPPSTSDE 715
            |.....:||||.:|...:.::|:.::.|:::.:      |.:|   :|::|
Mouse  1086 WRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGID---ATAEE 1133

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 29/128 (23%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 0/8 (0%)
Ig strand E 157..161 CDD:409353 2/21 (10%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 2/3 (67%)
Ig 200..289 CDD:472250 19/101 (19%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 129/299 (43%)
Tie1NP_035717.2 ig 127..208 CDD:395002
Furin-like 220..336 CDD:395614
EGF_Lam 225..263 CDD:238012
Ig 348..439 CDD:472250
Ig strand B 366..370 CDD:409353
Ig strand C 382..386 CDD:409353
Ig strand E 407..411 CDD:409353
Ig strand F 421..426 CDD:409353
Ig strand G 434..437 CDD:409353
fn3 447..518 CDD:394996
fn3 546..628 CDD:394996 18/84 (21%)
fn3 641..725 CDD:394996 16/102 (16%)
PTKc_Tie1 832..1128 CDD:270671 131/315 (42%)
Blue background indicates that the domain is not in the aligned region.

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