DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Tie1

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_035717.2 Gene:Tie1 / 21846 MGIID:99906 Length:1134 Species:Mus musculus


Alignment Length:701 Identity:205/701 - (29%)
Similarity:299/701 - (42%) Gaps:200/701 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PSGSLLTLNCHALGNPEPNI-----TWYRNG----TVDWT------RGYGSLKRNRW-------- 157
            || :|:|.:|     |||.:     :|:..|    .|.|:      .|.|.|.| .|        
Mouse   532 PS-ALMTTDC-----PEPLLQPWLESWHVEGPDRLRVSWSLPSVPLSGDGFLLR-LWDGARGQER 589

  Fly   158 ----------TLTMEDLVPGDCGNYTCKV----CNSLG----------------CIRH-DTQVIV 191
                      |..:..|.||.  :|...|    |..||                ..|| ..|.:.
Mouse   590 RENISFPQARTALLTGLTPGT--HYQLDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALS 652

  Fly   192 SDRVN---HKPILMTGPLNLTLVVNSTGSMHCKYLSDL-----TSKKAWIFVPCHGMTNCSNNRS 248
            ...:.   ..|...:||::             ||:.::     :....|:.|      :.....|
Mouse   653 DSEIQLMWQHPEAPSGPIS-------------KYIVEIQVAGGSGDPQWMDV------DRPEETS 698

  Fly   249 IIAE--DKDQLDFVNVRMEQEG---WYTCVESNSLG---QSNSTAYLRVVRSLHVLEAGV----- 300
            ||..  :........||...:|   |...||..:||   ||...     ||.....|.|:     
Mouse   699 IIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGP-----VRESRAAEEGLDQQLV 758

  Fly   301 --ASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363
              ..||:.:|...           .:..|.....||:    ..|.:|....:|          .|
Mouse   759 LAVVGSVSATCLT-----------ILAALLALVCIRR----SCLHRRRTFTYQ----------SG 798

  Fly   364 GGD------SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422
            .|:      |||::              |...:...:|.|.:   :|: ..||    .:.....:
Mouse   799 SGEETILQFSSGTL--------------TLTRRPKPQPEPLS---YPV-LEWE----DITFEDLI 841

  Fly   423 GEGAFGRVVMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS 481
            |||.||:|:.|.:.      ||  |:||:||..:::|......|:||:..:|.|.|||||||.|.
Mouse   842 GEGNFGQVIRAMIKKDGLKMNA--AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACE 904

  Fly   482 QNGPLYVIVEYAPHGNLKDFLYKNR------PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQI 540
            ..|.||:.:||||:|||.|||.|:|      .|.|:..          .|..::.:.|::||...
Mouse   905 NRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHG----------TASTLSSRQLLRFASDA 959

  Fly   541 ARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESL 605
            |.||.||:.::.||||||||||||.::...|||||||:|   ..:.|.|.|.||||::|||.|||
Mouse   960 ANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESL 1021

  Fly   606 QEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQC 670
            ....|.:||||||:|:|||||::.|..|| ..|:..|||..|..|.|||:|..|...:|.|||||
Mouse  1022 NYSVYTTKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC 1085

  Fly   671 WHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLDTPPSTSDE 715
            |.....:||||.:|...:.::|:.::.|:::.:      |.:|   :|::|
Mouse  1086 WRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGID---ATAEE 1133

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 29/128 (23%)
IG_like 113..191 CDD:214653 29/128 (23%)
IG_like 205..289 CDD:214653 18/96 (19%)
PKc_like 404..692 CDD:304357 129/299 (43%)
STYKc 416..688 CDD:214568 126/283 (45%)
Tie1NP_035717.2 ig 127..208 CDD:278476
IG_like 131..210 CDD:214653
EGF_Lam 225..263 CDD:238012
EGF_CA 312..343 CDD:238011
ig 353..439 CDD:278476
IG 367..441 CDD:214652
fn3 447..518 CDD:278470
fn3 546..628 CDD:278470 18/84 (21%)
FN3 640..732 CDD:238020 19/110 (17%)
PTKc_Tie1 832..1128 CDD:270671 131/315 (42%)
TyrKc 835..1103 CDD:197581 126/283 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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