DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Tek

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus

Alignment Length:	713	Identity:	204/713 - (28%)
Similarity:	311/713 - (43%)	Gaps:	173/713 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VNVSSKPYWRN-PKKMSFLQTRP----------SGSLLTLN----------CHAL--------GN 130
            :|:||:||:.: |.|...|..:|          :..:.|||          |..|        |:
Mouse   463 INISSEPYFGDGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEPRTDYELCVQLARPGEGGEGH 527

  Fly   131 PEP---------------------------NITWYRNGTVDWTRGYGSLKRNRWTLTMED---LV 165
            |.|                           |:||....|......|..::|.....|.:.   .|
Mouse   528 PGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTNSEDEFYVEVERRSLQTTSDQQNIKV 592

  Fly   166 PGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHK---------------PILMTGPLNLTLVVNST 215
            |   ||.|..:.::|  :..: |..|..|||.|               .||...|.|:.:
Mouse   593 P---GNLTSVLLSNL--VPRE-QYTVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKI----- 646

  Fly   216 GSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVR-----------MEQEGW 269
                 ..::|.|:..:|..|..:.:::......:..:::||...|.::           :|.|..
Mouse   647 -----SNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLKGLEPETT 706

  Fly   270 Y--TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYA 332
            |  .....|::|.||..    ....|..|....||..|.....:.|.:.|......:|.|..|..
Mouse   707 YHVDIFAENNIGSSNPA----FSHELRTLPHSPASADLGGGKMLLIAILGSAGMTCITVLLAFLI 767

  Fly   333 IRKMKHEKV---LKQRIETVHQWTKKVIIFKPEGGGDSSGSM----------DTMIMPVVRIQKQ 384
            :.::|...|   :.|..:.|.:  :..:.|       :||::          |..|.||:
Mouse   768 MLQLKRANVQRRMAQAFQNVRE--EPAVQF-------NSGTLALNRKAKNNPDPTIYPVL----- 818

  Fly   385 RTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAIVAVKMV 445
                        .:|:.:|.               ..:|||.||:|:.|.:.    ....|:|.:
Mouse   819 ------------DWNDIKFQ---------------DVIGEGNFGQVLKARIKKDGLRMDAAIKRM 856

  Fly   446 KEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGR 510
            ||..:.||......|:||:..:|.|.|||||||.|...|.||:.:||||||||.|||.|:|..
Mouse   857 KEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVL-- 919

  Fly   511 DQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADF 575
              :.|.:....:..|..::.:.|:.||..:|||||||:.::.|||||||||:||.::|:.|||||
Mouse   920 --ETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADF 982

  Fly   576 GLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSA 640
            ||:|   ..:.|.|.|.||||::|||.|||....|.:.|||||||:|||||::.|..|| ..|:.
Mouse   983 GLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY-CGMTC 1043

  Fly   641 EELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703
            .|||..|..|.|:|||..|...:|.||||||.....:||.|.:|:..::::|:.::.|::..:
Mouse  1044 AELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	24/136 (18%)
		IG_like	113..191	CDD:214653	23/135 (17%)
		IG_like	205..289	CDD:214653	16/96 (17%)
		PKc_like	404..692	CDD:304357	125/291 (43%)
		STYKc	416..688	CDD:214568	125/275 (45%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		EGF_2	311..340	CDD:285248
		fn3	445..516	CDD:278470	13/52 (25%)
		fn3	542..625	CDD:278470	19/88 (22%)
		FN3	638..730	CDD:238020	17/105 (16%)
		PTKc_Tie2	815..1117	CDD:133219	131/332 (39%)
		STYKc	823..1091	CDD:214568	126/290 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810