DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Tek

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_038718.2 Gene:Tek / 21687 MGIID:98664 Length:1123 Species:Mus musculus


Alignment Length:713 Identity:204/713 - (28%)
Similarity:311/713 - (43%) Gaps:173/713 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 VNVSSKPYWRN-PKKMSFLQTRP----------SGSLLTLN----------CHAL--------GN 130
            :|:||:||:.: |.|...|..:|          :..:.|||          |..|        |:
Mouse   463 INISSEPYFGDGPIKSKKLFYKPVNQAWKYIEVTNEIFTLNYLEPRTDYELCVQLARPGEGGEGH 527

  Fly   131 PEP---------------------------NITWYRNGTVDWTRGYGSLKRNRWTLTMED---LV 165
            |.|                           |:||....|......|..::|.....|.:.   .|
Mouse   528 PGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTNSEDEFYVEVERRSLQTTSDQQNIKV 592

  Fly   166 PGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHK---------------PILMTGPLNLTLVVNST 215
            |   ||.|..:.::|  :..: |..|..|||.|               .||...|.|:.:     
Mouse   593 P---GNLTSVLLSNL--VPRE-QYTVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKI----- 646

  Fly   216 GSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVR-----------MEQEGW 269
                 ..::|.|:..:|..|..:.:::......:..:::||...|.::           :|.|..
Mouse   647 -----SNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLKGLEPETT 706

  Fly   270 Y--TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYA 332
            |  .....|::|.||..    ....|..|....||..|.....:.|.:.|......:|.|..|..
Mouse   707 YHVDIFAENNIGSSNPA----FSHELRTLPHSPASADLGGGKMLLIAILGSAGMTCITVLLAFLI 767

  Fly   333 IRKMKHEKV---LKQRIETVHQWTKKVIIFKPEGGGDSSGSM----------DTMIMPVVRIQKQ 384
            :.::|...|   :.|..:.|.:  :..:.|       :||::          |..|.||:     
Mouse   768 MLQLKRANVQRRMAQAFQNVRE--EPAVQF-------NSGTLALNRKAKNNPDPTIYPVL----- 818

  Fly   385 RTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAIVAVKMV 445
                        .:|:.:|.               ..:|||.||:|:.|.:.    ....|:|.:
Mouse   819 ------------DWNDIKFQ---------------DVIGEGNFGQVLKARIKKDGLRMDAAIKRM 856

  Fly   446 KEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGR 510
            ||..:.||......|:||:..:|.|.|||||||.|...|.||:.:||||||||.|||.|:|..  
Mouse   857 KEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVL-- 919

  Fly   511 DQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADF 575
              :.|.:....:..|..::.:.|:.||..:|||||||:.::.|||||||||:||.::|:.|||||
Mouse   920 --ETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADF 982

  Fly   576 GLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSA 640
            ||:|   ..:.|.|.|.||||::|||.|||....|.:.|||||||:|||||::.|..|| ..|:.
Mouse   983 GLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY-CGMTC 1043

  Fly   641 EELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703
            .|||..|..|.|:|||..|...:|.||||||.....:||.|.:|:..::::|:.::.|::..:
Mouse  1044 AELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL 1106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 28/148 (19%)
Ig strand B 121..125 CDD:409353 3/13 (23%)
Ig strand C 134..138 CDD:409353 2/3 (67%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 18/101 (18%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 1/6 (17%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 125/291 (43%)
TekNP_038718.2 Ig_Tie2_1 24..118 CDD:463089
EGF_Lam 230..275 CDD:238012
IgI_Tie2 348..439 CDD:409556
Ig strand A 348..352 CDD:409556
Ig strand A' 358..362 CDD:409556
Ig strand B 365..374 CDD:409556
Ig strand C 382..387 CDD:409556
Ig strand C' 391..393 CDD:409556
Ig strand D 397..401 CDD:409556
Ig strand E 404..412 CDD:409556
Ig strand F 420..428 CDD:409556
Ig strand G 431..439 CDD:409556
fn3 445..516 CDD:394996 13/52 (25%)
fn3 542..625 CDD:394996 19/88 (22%)
FN3 638..730 CDD:238020 17/105 (16%)
PTKc_Tie2 815..1117 CDD:133219 131/332 (39%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.