DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Tec

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001106931.1 Gene:Tec / 21682 MGIID:98662 Length:630 Species:Mus musculus


Alignment Length:497 Identity:131/497 - (26%)
Similarity:212/497 - (42%) Gaps:104/497 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 STGSMHCKYLSDLTSKKA-------WIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYT 271
            |.|.:...|   :|.||:       |.   |.. ||.|....::..:..:..|:.....|.|.||
Mouse   224 SEGYIPSNY---VTGKKSNNLDQYEWY---CRN-TNRSKAEQLLRTEDKEGGFMVRDSSQPGLYT 281

  Fly   272 CVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYI---FVFGGLIFIFMTTLFVFYAI 333
            .......|...|:.:    |..|:.|...      |....|:   ..||.:..|          |
Mouse   282 VSLYTKFGGEGSSGF----RHYHIKETAT------SPKKYYLAEKHAFGSIPEI----------I 326

  Fly   334 RKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPF 398
            ...||                           :::|.:..:..||       :|..:|....|.|
Mouse   327 EYHKH---------------------------NAAGLVTRLRYPV-------STKGKNAPTTAGF 357

  Fly   399 NEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREME 462
            : |:     .||:..|.|.....||.|.||.|.:.:..... ||:|.::||...::  ..:.|.:
Mouse   358 S-YD-----KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEE--DFIEEAK 414

  Fly   463 VMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR-PFGRDQDRDSSQPPPSPPAH 526
            ||..: .|..::.|.|.|:|..|:|::.|:...|.|.:||.:.: .|.||.              
Mouse   415 VMMKL-THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDM-------------- 464

  Fly   527 VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT 591
                  |:.....:..||:||.....|||||||||.||::..|:|::|||:||.:.. |.|..::
Mouse   465 ------LLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLD-DQYTSSS 522

  Fly   592 NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKP 656
            ..:.|:||..||......:.|||||||:|:|:|||.|.|:.|:.. .:..|:.|.:..|.|:.:|
Mouse   523 GAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEK-NTNYEVVTMVTRGHRLHRP 586

  Fly   657 AKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDY 698
            ...|..:|.:|.:||....:.||.|.:::..:|:|::.:|.:
Mouse   587 KLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETF 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 18/81 (22%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 2/10 (20%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 92/289 (32%)
TecNP_001106931.1 PH_Btk 7..148 CDD:269944
SH3_Tec 182..236 CDD:212838 4/14 (29%)
SH2_Tec_Itk 239..346 CDD:198259 26/164 (16%)
PTKc_Tec_Rlk 364..623 CDD:270685 91/283 (32%)
Blue background indicates that the domain is not in the aligned region.

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