DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and ERBB4

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_016859066.1 Gene:ERBB4 / 2066 HGNCID:3432 Length:1349 Species:Homo sapiens


Alignment Length:660 Identity:164/660 - (24%)
Similarity:271/660 - (41%) Gaps:166/660 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 NITWYRNGTVDWTRGYGSL--------KRNRWTLTMEDLV--------------PGDC------- 169
            |:.:|.  |::||..:.::        .|.....|.|.:|              |..|       
Human   491 NLCYYH--TINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFS 553

  Fly   170 -GNYTCKVCNSLG-----------CIRHDTQVIVSDRVN------HKPILMTGPLNLTLVVNSTG 216
             |....:.||...           |:..|.|   .:::.      |.|    ||.|.|...:...
Human   554 RGRICIESCNLYDGEFREFENGSICVECDPQ---CEKMEDGLLTCHGP----GPDNCTKCSHFKD 611

  Fly   217 SMHC--KYLSDLTSKKAWIFV---------PCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWY 270
            ..:|  |....|....::||.         |||  .||:.. .|.:..:|.:..:: |......:
Human   612 GPNCVEKCPDGLQGANSFIFKYADPDRECHPCH--PNCTQG-CIGSSIEDCIGLMD-RCNGPTSH 672

  Fly   271 TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRK 335
            .|:.....|.|....:.|.    .::.|||..|       ::|.|..||.|.      |:...:.
Human   673 DCIYYPWTGHSTLPQHART----PLIAAGVIGG-------LFILVIVGLTFA------VYVRRKS 720

  Fly   336 MKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNE 400
            :|.::.|::.:||                        .::.|:.          .:|..|   |:
Human   721 IKKKRALRRFLET------------------------ELVEPLT----------PSGTAP---NQ 748

  Fly   401 YEFPLDSNWELPRSHLVLGATLGEGAFGRVVM------AEVNNAIVAVKMVKEGHTDDDIASLVR 459
            .:..:....||.|..:     ||.||||.|..      .|.....||:|::.|..........:.
Human   749 AQLRILKETELKRVKV-----LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMD 808

  Fly   460 EMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPP 524
            |..:|..:. |.:::.|||.| .:..:.::.:..|||.|.:::::::      |...||.     
Human   809 EALIMASMD-HPHLVRLLGVC-LSPTIQLVTQLMPHGCLLEYVHEHK------DNIGSQL----- 860

  Fly   525 AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRK 589
                    |:.:..|||:||.||..||.:|||||||||||.....:||.||||||.::..:....
Human   861 --------LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYN 917

  Fly   590 NTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRME 654
            ...|::||||||.|.:..:.:..:|||||||:.:||:||:|.:||..| ...|:...|..|:|:.
Human   918 ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLLEKGERLP 981

  Fly   655 KPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSD----- 714
            :|..|::::|::|.:||..:||.||.|.|:.....::.:..:.||.:...:....||.:|     
Human   982 QPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQ 1046

  Fly   715 ---EEEDETD 721
               :|||..|
Human  1047 NLLDEEDLED 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 17/97 (18%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 0/4 (0%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 20/99 (20%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 97/293 (33%)
ERBB4XP_016859066.1 Recep_L_domain 55..167 CDD:460032
Furin-like 215..358 CDD:395614
Recep_L_domain 384..504 CDD:460032 5/14 (36%)
GF_recep_IV 528..660 CDD:464344 27/141 (19%)
TM_ErbB4 683..726 CDD:213053 13/59 (22%)
PTKc_HER4 751..1053 CDD:173655 103/328 (31%)
Blue background indicates that the domain is not in the aligned region.

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