Protein Alignment htl and EPHB6

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_004436.4
• Gene: EPHB6 / 2051
• HGNCID: 3396
• Length: 1022
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 155/682 - (22%)
• Similarity: 259/682 - (37%)
• Gaps: 178/682 - (26%)

  Fly   145 WTRGYGSLKRNRWTLTME-----DLV-------------PGDCGNYTCKVCNSLGCIRHD----- 186
            |....||.....|.|..|     ||:             |...|..||..|...  :..|
Human   378 WFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDE--VHFDPRQRG 440

  Fly   187 ---TQVIVSDRVNHKPILMTGPLNLTLVVNSTGSM-----HCKYLSDLTSKKAWIFVP-CHGMTN 242
               ::|:|.....|.|.::.     ...||....:     ....::..||.:....|| .|.::.
Human   441 LTESRVLVGGLRAHVPYILE-----VQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSR 500

  Fly   243 CSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNS----LGQSNSTAYLRVVRSLHV----LEAG 299
            .||:.::.....||.: .|:...|..:|...|..|    |....:||.:..:...|:    :.|.
Human   501 ASNSITVSWPQPDQTN-GNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRAR 564

  Fly   300 VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGG 364
            .|:|  |..       :||.::        |..:.:.:....|.:|:..|.
Human   565 TAAG--HGP-------YGGKVY--------FQTLPQGELSSQLPERLSLVI-------------- 598

  Fly   365 GDSSGSMDTMIMPVVRI-----QKQR-----TTVLQNGNEPA--------PFNEYEFPLDSNWEL 411
            |...|::..:::..:.:     |::|     |..||..:.|.        | :.||.|..:..||
Human   599 GSILGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDP-STYEDPCQAIREL 662

  Fly   412 PR----SHLVLGATLGEGAFGRVVMAEV-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKII 467
            .|    :::.:...:|.|:||.|....:     ....||::.:..|..         |...|..:
Human   663 AREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGA---------ESLQMTFL 718

  Fly   468 GR--------HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPP 524
            ||        |.||:.|.|..:::.||.|:.|:...|.|..||.:     |:....|.|
Human   719 GRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQ-----REGQFSSLQ------ 772

  Fly   525 AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRK 589
                    |:.....:|..|.||:|...:||.|:|.:|||:...|.|:|..|.:....|
Human   773 --------LVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPS------ 823

  Fly   590 NTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRME 654
                 ..::|.|||.:....:.:.|||||:|||:||:|:||::|| ..||.:|:...:....|:.
Human   824 -----CLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPY-WDMSEQEVLNAIEQEFRLP 882

  Fly   655 KPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLD------------------V 701
            .|..|...:::||...|..:...||.|.::|...||::: |.|.|.                  :
Human   883 PPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIR-KPDTLQAGGDPGERPSQALLTPVAL 946

  Fly   702 DIANLDTPPS--TSDEEEDETDNLQKW--CNY 729
            |...||:|.:  ::...|...||..|:  |.:
Human   947 DFPCLDSPQAWLSAIGLECYQDNFSKFGLCTF 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	15/71 (21%)
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353	2/3 (67%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	1/10 (10%)
		Ig	200..289	CDD:472250	19/98 (19%)
		Ig strand B	216..220	CDD:409353	0/8 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	2/3 (67%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	84/304 (28%)
EPHB6	NP_004436.4	EphR_LBD_B6	33..232	CDD:198443
		Ephrin_rec_like	305..346	CDD:429604
		fn3	372..472	CDD:394996	20/100 (20%)
		fn3	490..572	CDD:394996	20/91 (22%)
		EphA2_TM	613..668	CDD:464211	13/55 (24%)
		Protein Kinases, catalytic domain	666..920	CDD:473864	80/293 (27%)
		SAM_EPH-B6	946..1014	CDD:188954	9/33 (27%)
		PDZ-binding. /evidence=ECO:0000255	1020..1022