Protein Alignment htl and EPHB3

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_004434.2
• Gene: EPHB3 / 2049
• HGNCID: 3394
• Length: 998
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 169/671 - (25%)
• Similarity: 270/671 - (40%)
• Gaps: 175/671 - (26%)

  Fly   114 TRPSGSLLTLNCHALGNPEPNITWYR--NGTVDWT--------RGYGSLKRNRWTLTMEDLVPGD 168
            |.|:.|:.|  ||.        .:||  :.:.|..        ||..| ..|..:|.:|...|.|
Human   311 TSPAASICT--CHN--------NFYRADSDSADSACTTVPSPPRGVIS-NVNETSLILEWSEPRD 364

  Fly   169 CG-------NYTCKVCNSLG----CIRHDTQVIVSDRVNHKPILMTGPLNLT--------LVVNS 214
            .|       |..||.|:..|    |.|.|      |.|...|    ..|.||        |:.::
Human   365 LGGRDDLLYNVICKKCHGAGGASACSRCD------DNVEFVP----RQLGLTERRVHISHLLAHT 419

  Fly   215 TGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAE---------------------DKDQ-- 256
            ..:...:.::.::.|..  ..|.:...|.:.|::..:|                     ::..
Human   420 RYTFEVQAVNGVSGKSP--LPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGV 482

  Fly   257 -LDFVNVRMEQ-EGWYTCVES--NSL---GQSNSTAYLRVVRSLHVLEAGVAS--GSLHSTS--- 309
             ||:.....|: ||..:.|.|  ||:   |......|:..||:..|...|..|  ....:||
Human   483 ILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERG 547

  Fly   310 -----------FVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363
                       .:......||:|:....:.....:||.:|
Human   548 SGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRH------------------------- 587

  Fly   364 GGDS--SGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPR----SHLVLGATL 422
            |.||  :..:...|.|.:::...            ||. ||.|.::..|..:    |.:.:...:
Human   588 GSDSEYTEKLQQYIAPGMKVYID------------PFT-YEDPNEAVREFAKEIDVSCVKIEEVI 639

  Fly   423 GEGAFGRVVMAEV-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCC 480
            |.|.||.|....:     ....||:|.:|.|:|:......:.|..:|   |:  |.|||.|.|..
Human   640 GAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIM---GQFDHPNIIRLEGVV 701

  Fly   481 SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMD 545
            :::.|:.::.|:..:..|..||..|         |..          .|...|:.....||.||.
Human   702 TKSRPVMILTEFMENCALDSFLRLN---------DGQ----------FTVIQLVGMLRGIAAGMK 747

  Fly   546 YLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR---DIQSTDYYRKNTNGRLPIKWMAPESLQE 607
            ||:....:||||||||:||:.:.|.|::||||:|   |..|...|..:..|::||:|.|||::..
Human   748 YLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 812

  Fly   608 KFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWH 672
            :.:.|.||||||||::||:|:||::|| ..||.:::...:....|:..|..|...::.||..||.
Human   813 RKFTSASDVWSYGIVMWEVMSYGERPY-WDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWV 876

  Fly   673 FNADDRPPFTEIVEYMDKLLQ 693
            .:.:.||.|::||..:|||::
Human   877 RDRNLRPKFSQIVNTLDKLIR 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	26/97 (27%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	20/126 (16%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	1/6 (17%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	97/301 (32%)
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446
		Ephrin_rec_like	272..316	CDD:429604	2/4 (50%)
		fn3	341..436	CDD:394996	25/105 (24%)
		FN3	<473..542	CDD:238020	16/68 (24%)
		EphA2_TM	560..630	CDD:464211	17/107 (16%)
		PTKc_EphR_B	628..896	CDD:173638	95/290 (33%)
		SAM_superfamily	922..990	CDD:472832