DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and EPHB2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001296122.1 Gene:EPHB2 / 2048 HGNCID:3393 Length:1055 Species:Homo sapiens


Alignment Length:759 Identity:178/759 - (23%)
Similarity:304/759 - (40%) Gaps:200/759 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 ANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKK 108
            ||..:....|....|:..:...||...::....||||         ..|:|...           
Human   279 ANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLD---------PLDMPCTT----------- 323

  Fly   109 MSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYT 173
               :.:.|...:.::|..:|             .::||....|..|       ||||    .|..
Human   324 ---IPSAPQAVISSVNETSL-------------MLEWTPPRDSGGR-------EDLV----YNII 361

  Fly   174 CKVCNS--LGCIRHDTQVIVSDRVNHKPILMTGPLNLT--------LVVNSTGSMHCKYLSDLTS 228
            ||.|.|  ..|.|      ..|.|.:.|    ..|.||        |:.::..:...:.::.:|.
Human   362 CKSCGSGRGACTR------CGDNVQYAP----RQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTD 416

  Fly   229 KKAWIFVPCHGMTNCSNNR------SIIAEDKDQLDFVNVRMEQEG------------WYTCVES 275
            :..  |.|.....|.:.|:      ||:.:....:|.:.:...|..            :|    .
Human   417 QSP--FSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYY----E 475

  Fly   276 NSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFV-----------FGGLIFIFMTTLFV 329
            ..|.:.|:||......::.|  .|:.:|:      :|:|.           :.|.::        
Human   476 KELSEYNATAIKSPTNTVTV--QGLKAGA------IYVFQVRARTVAGYGRYSGKMY-------- 524

  Fly   330 FYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVV-----------RIQK 383
            |..:.:.:::..:::::        .:||      |.|:..:..:|..||           |...
Human   525 FQTMTEAEYQTSIQEKL--------PLII------GSSAAGLVFLIAVVVIAIVCNRRGFERADS 575

  Fly   384 QRTTVLQNGNE----PA------PFNEYEFPLDSNWELPR----SHLVLGATLGEGAFGRVVMAE 434
            :.|..||:...    |.      ||. ||.|.::..|..:    |.:.:...:|.|.||.|....
Human   576 EYTDKLQHYTSGHMTPGMKIYIDPFT-YEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGH 639

  Fly   435 V-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCCSQNGPLYVIVEY 492
            :     ....||:|.:|.|:|:......:.|..:|   |:  |.|:|:|.|..:::.|:.:|.|:
Human   640 LKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM---GQFDHPNVIHLEGVVTKSTPVMIITEF 701

  Fly   493 APHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDL 557
            ..:|:|..||.:|         |..          .|...|:.....||.||.|||....:||||
Human   702 MENGSLDSFLRQN---------DGQ----------FTVIQLVGMLRGIAAGMKYLADMNYVHRDL 747

  Fly   558 AARNVLVSDDYVLKIADFGLAR---DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSY 619
            ||||:||:.:.|.|::||||:|   |..|...|.....|::||:|.|||::|.:.:.|.||||||
Human   748 AARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSY 812

  Fly   620 GILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEI 684
            ||::||:|:||::|| ..|:.:::...:....|:..|..|...::.||..||..:.:.||.|.:|
Human   813 GIVMWEVMSYGERPY-WDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQI 876

  Fly   685 VEYMDKLLQTKEDY---------LDVDIANLDTPPSTSDEEEDE 719
            |..:||:::.....         :::.:.:...|..||....||
Human   877 VNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDE 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 18/91 (20%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 18/114 (16%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 99/301 (33%)
EPHB2NP_001296122.1 EphR_LBD_B2 19..196 CDD:198445
fn3 326..421 CDD:394996 26/130 (20%)
fn3 437..520 CDD:394996 14/94 (15%)
EphA2_TM 544..617 CDD:464211 18/79 (23%)
PTKc_EphR_B 616..884 CDD:173638 97/290 (33%)
SAM_EPH-B2 910..980 CDD:188951 5/11 (45%)
PDZ-binding (in isoform 2). /evidence=ECO:0000255 984..986
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 990..1055
Blue background indicates that the domain is not in the aligned region.

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