DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and EPHA8

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens


Alignment Length:745 Identity:169/745 - (22%)
Similarity:263/745 - (35%) Gaps:268/745 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 TMTSGSLVVLFLL----LSIWQPAV------QVEGRR---------QMANSQEMIKDHLGARSQN 60
            ::...||:|..||    .|.|..||      ..|.||         |.|.||.::     .|.: 
Human   391 SLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTNQAAPSQVVV-----IRQE- 449

  Fly    61 KTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNC 125
                   .|.|:|.|.                         .|:.|:       :|:|.:|    
Human   450 -------RAGQTSVSL-------------------------LWQEPE-------QPNGIIL---- 471

  Fly   126 HALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGC-------- 182
                  |..|.:|.....  .:.|.:||......|:..|.||....:..:...|.||        
Human   472 ------EYEIKYYEKDKE--MQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAME 528

  Fly   183 -------IRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGM 240
                   .|:||:.||...:.    |:||.:.|.|:      :.||                  .
Human   529 VETGKPRPRYDTRTIVWICLT----LITGLVVLLLL------LICK------------------K 565

  Fly   241 TNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSL 305
            .:|..:::....|::::.:.|                 ||:....:|    .||     ...|.|
Human   566 RHCGYSKAFQDSDEEKMHYQN-----------------GQAPPPVFL----PLH-----HPPGKL 604

  Fly   306 HSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHE-----KVLKQRIETVHQWTKKVIIFKPEGGG 365
            ....                    |||......|     :...:.||......:|:|     |.|
Human   605 PEPQ--------------------FYAEPHTYEEPGRAGRSFTREIEASRIHIEKII-----GSG 644

  Fly   366 DSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRV 430
            ||                                                       ||..:||:
Human   645 DS-------------------------------------------------------GEVCYGRL 654

  Fly   431 VMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCCSQNGPLYVIVEYA 493
            .:....:..||:|.:|.|:|:......:.|..:|   |:  |.|||.|.|..::.....::.||.
Human   655 RVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM---GQFDHPNIIRLEGVVTRGRLAMIVTEYM 716

  Fly   494 PHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLA 558
            .:|:|..||       |..|..            .|...|:.....:..||.||:....:|||||
Human   717 ENGSLDTFL-------RTHDGQ------------FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLA 762

  Fly   559 ARNVLVSDDYVLKIADFGLARDIQ-STDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGIL 622
            ||||||..:.|.|::||||:|.:: ..|.....|.|::||:|.|||::..:.:.|.|||||:|::
Human   763 ARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVV 827

  Fly   623 LWEIMTYGQQPY------PTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPF 681
            :||::.||::||      ..|.|.||       |.|:..|..|...::.||..|||.:...||.|
Human   828 MWEVLAYGERPYWNMTNRDVISSVEE-------GYRLPAPMGCPHALHQLMLDCWHKDRAQRPRF 885

  Fly   682 TEIVEYMDKLLQTKEDYLDVDIANLDTPPS 711
            ::||..:|.|:::.|........:...||:
Human   886 SQIVSVLDALIRSPESLRATATVSRCPPPA 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 21/104 (20%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 0/4 (0%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 13/88 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 0/4 (0%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 92/296 (31%)
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656
FN3 <326..>519 CDD:442628 37/184 (20%)
fn3 439..524 CDD:394996 26/141 (18%)
EphA2_TM <562..632 CDD:464211 17/133 (13%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 2/23 (9%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 14/88 (16%)
PTKc_EphR_A 630..896 CDD:270651 100/354 (28%)
SAM_EPH-A8 933..995 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1003..1005
Blue background indicates that the domain is not in the aligned region.

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