DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and EPHA3

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_005224.2 Gene:EPHA3 / 2042 HGNCID:3387 Length:983 Species:Homo sapiens


Alignment Length:749 Identity:181/749 - (24%)
Similarity:300/749 - (40%) Gaps:217/749 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 SADLDDGA----ADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNIT 136
            |:..:||:    .:::..:||           ::|..|:.  |||..|           |. |:.
Human   294 SSTQEDGSMNCRCENNYFRAD-----------KDPPSMAC--TRPPSS-----------PR-NVI 333

  Fly   137 WYRNGT---VDWTRGYGSLKRNRWTLTMEDLVPGDCG-------NYTCKVC--NSLGC------I 183
            ...|.|   :||:          |        |.|.|       |..||.|  |...|      :
Human   334 SNINETSVILDWS----------W--------PLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNV 380

  Fly   184 RH--------DTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGM 240
            |.        :|.|.|:|.:.|        .|.|..:::...     :|:|:|.... |......
Human   381 RFLPRQFGLTNTTVTVTDLLAH--------TNYTFEIDAVNG-----VSELSSPPRQ-FAAVSIT 431

  Fly   241 TNCSNNRSIIAEDKDQ--------------------LDF---VNVRMEQEGWYTCVESNSLGQSN 282
            ||.:....::...||:                    ||:   ...:.|||..||.:.:.....:.
Human   432 TNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTI 496

  Fly   283 S-----TAYLRVVRSLHVLEAGVASGSLH------------STSFVYIFVFGGLIFIFMTTLFVF 330
            |     |.|:..:|:......|..|....            .:|.|.:......:.|.:.|:.::
Human   497 SSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIY 561

  Fly   331 YAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP 395
            ..|.:....|       :.|...:|.:.|   |.|.            :::...||.|     :|
Human   562 VLIGRFCGYK-------SKHGADEKRLHF---GNGH------------LKLPGLRTYV-----DP 599

  Fly   396 APFNEYEFPLDS----NWELPRSHLVLGATLGEGAF-----GRVVMAEVNNAIVAVKMVKEGHTD 451
               :.||.|..:    ..||..:::.:...:|.|.|     ||:.:.......||:|.:|.|:|:
Human   600 ---HTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTE 661

  Fly   452 DDIASLVREMEVMKIIGR--HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDR 514
            ......:.|..:|   |:  |.|||.|.|..:::.|:.::.||..:|:|..||.|:         
Human   662 KQRRDFLGEASIM---GQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH--------- 714

  Fly   515 DSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR 579
            |:.          .|...|:.....||.||.||:....:||||||||:|::.:.|.|::||||:|
Human   715 DAQ----------FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSR 769

  Fly   580 DIQSTDYYRKNT-NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEEL 643
            .::........| .|::||:|.:||::..:.:.|.||||||||:|||:|:||::|| ..||.:::
Human   770 VLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPY-WEMSNQDV 833

  Fly   644 YTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ------------TKE 696
            ...:..|.|:..|..|...:|.||..||..:.::||.|.:||..:|||::            .:.
Human   834 IKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARP 898

  Fly   697 DYLDVDIANLD--TPPSTSDEEEDETDNLQKWCN 728
            ..|.:|.:|:|  |..:|.|           |.|
Human   899 SNLLLDQSNVDITTFRTTGD-----------WLN 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 25/115 (22%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/10 (10%)
Ig 200..289 CDD:472250 20/116 (17%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/23 (9%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/7 (14%)
Protein Kinases, catalytic domain 404..692 CDD:473864 98/299 (33%)
EPHA3NP_005224.2 EphR_LBD_A3 29..201 CDD:198449
FN3 <323..>543 CDD:442628 50/263 (19%)
FN3 437..528 CDD:238020 15/90 (17%)
EphA2_TM 555..618 CDD:464211 17/92 (18%)
PTKc_EphR_A 616..882 CDD:270651 96/288 (33%)
SAM_superfamily 912..974 CDD:472832 5/21 (24%)
PDZ-binding. /evidence=ECO:0000255 981..983
Blue background indicates that the domain is not in the aligned region.

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