DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and EPHA1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens


Alignment Length:594 Identity:146/594 - (24%)
Similarity:249/594 - (41%) Gaps:124/594 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 NYTCKV-----CNSLGCIRH-DTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSK 229
            |||..|     .:.||...| .|.|.:|  :.|...|  ..|:|.||......:...:....   
Human   414 NYTFNVEAQNGVSGLGSSGHASTSVSIS--MGHAESL--SGLSLRLVKKEPRQLELTWAGSR--- 471

  Fly   230 KAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLH 294
                  |.....|.:....::.:|:::...|   :|.....|.::.:       |.|:..||.|.
Human   472 ------PRSPGANLTYELHVLNQDEERYQMV---LEPRVLLTELQPD-------TTYIVRVRMLT 520

  Fly   295 VLEAG------------VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIE 347
            .|..|            ..|..|.....|.: :||.|:...:....:.:..|:.:.::..:||  
Human   521 PLGPGPFSPDHEFRTSPPVSRGLTGGEIVAV-IFGLLLGAALLLGILVFRSRRAQRQRQQRQR-- 582

  Fly   348 TVHQWTKKVIIFKPEGGGDSSGSMD----TMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFP---- 404
                              |.:..:|    ..:.|.|.:|                 .||.|    
Human   583 ------------------DRATDVDREDKLWLKPYVDLQ-----------------AYEDPAQGA 612

  Fly   405 LDSNWELPRSHLVLGATLGEGAFGRVV-----MAEVNNAIVAVKMVKEGHTDDDIASLVREMEVM 464
            ||...||..:.|::...:|||.||.|.     :...:...||:|.:|:........:.:||..:|
Human   613 LDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIM 677

  Fly   465 KIIGR--HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHV 527
               |:  |.:|::|.|..::..|:.:|.|:..:|.|..||         ::|:....|       
Human   678 ---GQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFL---------REREDQLVP------- 723

  Fly   528 ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTN 592
               ..|:.....||.||:||::...:||||||||:||:.:...|::||||.|.:...|...:...
Human   724 ---GQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQG 785

  Fly   593 GRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPA 657
            |::||:|.|||::..:.:.:.|||||:||::||::::|.:||.. ||.:|:...:..|.|:..|.
Human   786 GKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGE-MSNQEVMKSIEDGYRLPPPV 849

  Fly   658 KCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTP-----PSTSDEEE 717
            .|...:|.||:.||.::...||.|.::..::::||.......  .|||.|..     ||.|..:.
Human   850 DCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLR--TIANFDPRMTLRLPSLSGSDG 912

  Fly   718 DETDNLQKW 726
            .....:.:|
Human   913 IPYRTVSEW 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 9/25 (36%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353 3/4 (75%)
Ig strand G 184..187 CDD:409353 1/3 (33%)
Ig 200..289 CDD:472250 13/88 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 91/298 (31%)
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447
fn3 334..431 CDD:394996 6/16 (38%)
FN3 453..535 CDD:238020 16/100 (16%)
EphA2_TM <586..621 CDD:464211 11/51 (22%)
Protein Kinases, catalytic domain 619..884 CDD:473864 87/287 (30%)
SAM_EPH-A1 912..974 CDD:188941 1/10 (10%)
PDZ-binding. /evidence=ECO:0000255 974..976
Blue background indicates that the domain is not in the aligned region.

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