Protein Alignment htl and Ripk1

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_033094.3
• Gene: Ripk1 / 19766
• MGIID: 108212
• Length: 656
• Species: Mus musculus
• Alignment Length: 361
• Identity: 101/361 - (27%)
• Similarity: 155/361 - (42%)
• Gaps: 71/361 - (19%)

  Fly   402 EFPLDSNWELPRSHLVLGATLGEGAFGRVVMA-EVNNAIVAVKMVKEGHTDDDIASLVREMEVMK 465
            :..|| |.::..|.|:....|..|.||:|.:. ..::..|.:|.|..|....:...::.|...|.
Mouse     4 DMSLD-NIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMM 67

  Fly   466 IIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITE 530
            ...||..::.|||...:.|...:::||...|||...|           :.....|.|....:|.|
Mouse    68 HRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVL-----------KTQIDVPLSLKGRIIVE 121

  Fly   531 KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLA----------------R 579
                     ...||.||..:..||:||...|:||..|:.:||||.|:|                :
Mouse   122 ---------AIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQK 177

  Fly   580 DIQSTDYYRKNTNGRLPIKWMAPESLQE--KFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEE 642
            ::.||.  :||..|.|  .:||||.|.:  .....||||:|:||:||.|.. .::||..::..|:
Mouse   178 EVSSTT--KKNNGGTL--YYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFA-KKEPYENVICTEQ 237

  Fly   643 LYTYLMSGQR--MEKPAK-CSMNIYILMRQCWHFNADDRPPFTEI-VEYMDKLLQTKEDYLDVDI 703
            ....:.||.|  :|:..: |...|..||.:||....:|||.|..| .|:....|...|:|::.|:
Mouse   238 FVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDV 302

  Fly   704 ANL----------------------DTPPSTSDEEE 717
            |:|                      ..|||.|:.|:
Mouse   303 ASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQ 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	90/310 (29%)
Ripk1	NP_033094.3	Protein Kinases, catalytic domain	23..291	CDD:473864	85/292 (29%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546	291..567		11/48 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..373		5/12 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..423
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682	520..536
		Death_RIP1	568..653	CDD:260048