Protein Alignment htl and Ret

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_033076.2
• Gene: Ret / 19713
• MGIID: 97902
• Length: 1115
• Species: Mus musculus
• Alignment Length: 363
• Identity: 156/363 - (42%)
• Similarity: 213/363 - (58%)
• Gaps: 30/363 - (8%)

  Fly   385 RTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMA-------EVNNAIVAV 442
            |...|.:.....|.:.::.|.|..||.||.:||||.|||||.||:||.|       ......|||
Mouse   694 RRPSLDSTENQVPVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAV 758

  Fly   443 KMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP 507
            ||:||..:..::..|:.|..::|.: .|.::|.|.|.|||:|||.:|||||.:|:|:.||..:|.
Mouse   759 KMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRK 822

  Fly   508 FG-----RDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDD 567
            .|     ....|:||. ...|...|:|..|||.||.||:|||.|||..:.:||||||||:||::.
Mouse   823 IGPAYVSGGGSRNSSS-LDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEG 886

  Fly   568 YVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQ 632
            ..:||:||||:||:...|.|.|.:.||:|:||||.|||.:..|.::|||||:|:|||||:|.|..
Mouse   887 RKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGN 951

  Fly   633 PYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKED 697
            |||.| ..|.|:..|.:|.|||:|..||..:|.||.|||....|.||.|.:|.:.::|::....|
Mouse   952 PYPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRD 1015

  Fly   698 YLDVDIANLDTPPST-------SDEEEDETDNLQKWCN 728
            |||:..:   ||..:       |:||....|     ||
Mouse  1016 YLDLAAS---TPSDSLLYDDGLSEEETPLVD-----CN 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	141/299 (47%)
Ret	NP_033076.2	RET_CLD1	29..154	CDD:465485
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949	29..153
		Cadherin	173..262	CDD:394985
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949	266..380
		RET_CLD3	266..380	CDD:465516
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949	407..508
		RET_CLD4	409..508	CDD:465517
		PTKc_RET	724..1013	CDD:173631	135/291 (46%)