Protein Alignment htl and EPHA2

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_054190833.1
• Gene: EPHA2 / 1969
• HGNCID: 3386
• Length: 978
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 184/707 - (26%)
• Similarity: 282/707 - (39%)
• Gaps: 185/707 - (26%)

  Fly    94 PVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWT--RGYGSLKRNR 156
            |.:.:|.|..|.|....:|.....|:.:.|.                    ||  :..|..:...
Human   319 PQDPASMPCTRPPSAPHYLTAVGMGAKVELR--------------------WTPPQDSGGREDIV 363

  Fly   157 WTLTMEDLVP--GDCGNYTCKVCNS---LGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTG 216
            :::|.|...|  |:||.....|..|   .|..|  |.|.|||...|        :|.|..|.:.
Human   364 YSVTCEQCWPESGECGPCEASVRYSEPPHGLTR--TSVTVSDLEPH--------MNYTFTVEAR- 417

  Fly   217 SMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSI--IAEDKDQLDFVNVRMEQEG----------- 268
                                 :|::....:||.  .:...:|.:...||:|...
Human   418 ---------------------NGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIP 461

  Fly   269 -------WYTCVESNSLGQSNS-------------------TAYLRVVRSLHVLEAGVASGS-LH 306
                   |...|.....|.|||                   |.||..|::|  .:.|..:|| :|
Human   462 PPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQAL--TQEGQGAGSKVH 524

  Fly   307 STSFV------YIFVFGGLIFIFMTTLFV-----FYAIRKMKHEKVLKQRIETVHQWTKKVIIFK 360
            ....:      .:.|.|| :.:.:..|.|     |:..|:.|:::. :|..|.|  :..|....|
Human   525 EFQTLSPEGSGNLAVIGG-VAVGVVLLLVLAGVGFFIHRRRKNQRA-RQSPEDV--YFSKSEQLK 585

  Fly   361 PEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFP----LDSNWELPRSHLVLGAT 421
            |         :.|.:.|                     :.||.|    |....|:..|.:.....
Human   586 P---------LKTYVDP---------------------HTYEDPNQAVLKFTTEIHPSCVTRQKV 620

  Fly   422 LGEGAFGRVVMAEVNNAI------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCC 480
            :|.|.||.|....:..:.      ||:|.:|.|:|:......:.|..:|.....| |||.|.|..
Human   621 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH-NIIRLEGVI 684

  Fly   481 SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMD 545
            |:..|:.:|.||..:|.|..||       |::|.:.|         |:   .|:.....||.||.
Human   685 SKYKPMMIITEYMENGALDKFL-------REKDGEFS---------VL---QLVGMLRGIAAGMK 730

  Fly   546 YLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTN-GRLPIKWMAPESLQEKF 609
            |||:...:||||||||:||:.:.|.|::||||:|.::........|: |::||:|.|||::..:.
Human   731 YLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK 795

  Fly   610 YDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFN 674
            :.|.|||||:||::||:||||::|| ..:|..|:...:..|.|:..|..|...||.||.|||...
Human   796 FTSASDVWSFGIVMWEVMTYGERPY-WELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQE 859

  Fly   675 ADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTP-----PSTSDEEEDETDNLQKW 726
            ...||.|.:||..:|||::..:..  ..:|:.|..     ||||..|......:.:|
Human   860 RARRPKFADIVSILDKLIRAPDSL--KTLADFDPRVSIRLPSTSGSEGVPFRTVSEW 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	21/96 (22%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	19/127 (15%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	2/21 (10%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	105/298 (35%)
EPHA2	XP_054190833.1	EphR_LBD_A2	30..203	CDD:198448
		fn3	332..426	CDD:394996	26/145 (18%)
		fn3	440..521	CDD:394996	15/82 (18%)
		EphA2_TM	<558..612	CDD:464211	16/86 (19%)
		PTKc_EphR_A2	609..877	CDD:133194	103/288 (36%)
		SAM_EPH-A2	904..973	CDD:188942	2/11 (18%)