DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and old-1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_496130.2	Gene:	old-1 / 191737	WormBaseID:	WBGene00003862	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	148/544 - (27%)
Similarity:	245/544 - (45%)	Gaps:	109/544 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 IFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLE 297
            :|...:|..:|:                          |.:.|:||.::...:..|:.||....|
Worm     9 VFYSSYGFAHCN--------------------------TILRSSSLSRNFEDSLRRIPRSTDKDE 47

  Fly   298 AGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRK-------MKHEKVLKQRIETVHQWTKK 355
            .|....::....|:.::.....:.|.:..|.:||..||       .:.::.|.:.....|:....
Worm    48 TGFEDSNVQEVIFILLYCLFVALAILICGLIIFYNSRKRELRANRSRGDEYLLEPTSADHKRRNS 112

  Fly   356 VIIFKPEGG--GDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP-----APFNE------YEFPLDS 407
            ..|..||..  ..:||..|.         :|..:.|.|...|     ||.||      |...::.
Worm   113 SNIVPPEPTPYPITSGESDL---------RQTPSRLSNVECPPELELAPINEKIMYLHYYAEVEI 168

  Fly   408 NWELPRSHLVLGATLGEGAFGRVVMA-----------EVNNAIVAVKMVKEGHTDDDIASLVREM 461
            |.|  ...:..|..||.|.||.:...           :.:...||||:....:.......:..|:
Worm   169 NEE--DLDISKGRPLGSGEFGIIRKGFLRSKNSKNEEKESRLEVAVKLPLNEYNQIQQELIYDEL 231

  Fly   462 EVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR-PFGRDQ-----DRDSSQPP 520
            :||..:|:|.||:.|:|..:......::.|:..:|:|..||..|| .|..||     ::||
Worm   232 KVMCAVGKHPNILALVGGITFGERKMIVSEFVENGDLLSFLRDNRIYFTNDQWTLETEQDS---- 292

  Fly   521 PSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTD 585
                   ::..||:.||.|||:||:||....|:|||||.||||:..:.:::||||||||..::.|
Worm   293 -------LSLVDLLSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKKNRIIRIADFGLARRHKNKD 350

  Fly   586 YYR-KNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEE------- 642
            ||: ::.:..|||.||||||:.:..:..||||||||:.|:|:.:.|:.||..::..::
Worm   351 YYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYENVIKYDQRDFYWKY 415

  Fly   643 LYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT--KEDYLDVDIAN 705
            :.:||..|:|:.:||.....||.:|:.||..:.:.|..|.:.:|:.:|.|:|  .|.:||:
Worm   416 VLSYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFEKELKTTSNEYFLDL---- 476

  Fly   706 LDTPPSTSDEEEDETDN---LQKW 726
                   :.:...||:|   |..|
Worm   477 -------TRKLRSETNNQLRLSNW 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	7/55 (13%)
		PKc_like	404..692	CDD:304357	102/312 (33%)
		STYKc	416..688	CDD:214568	99/296 (33%)
old-1	NP_496130.2	TyrKc	175..461	CDD:197581	99/296 (33%)
old-1	NP_496130.2	PTKc	179..462	CDD:270623	98/293 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3298
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760