DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and F59F5.3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_509765.2	Gene:	F59F5.3 / 186634	WormBaseID:	WBGene00010342	Length:	681	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	148/752 - (19%)
Similarity:	262/752 - (34%)	Gaps:	254/752 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHL-GARSQNK--TPAITNNANQ 71
            :|:::.:|...:                   |...||.|::|.|: ..|..|.  ...|.:..|.
Worm   109 THTSVDLTHSKI-------------------RCTRNSIEIMKFHMFVGRDDNMFFKNTIVSKLNG 154

  Fly    72 SS-----TSSADLDDGAADDDDNKADLPVNVSSKPYW----RNPKKMSFLQTRPSGSLLTLNCHA 127
            :.     :.|...::....::....|:|.| ..|.::    |||.. .|.|...:..|::.....
Worm   155 TGVYLQCSGSYHTENVKLLENQKSLDIPYN-PFKGFYIDISRNPIN-RFYQCEHNDELISFKLQN 217

  Fly   128 LGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVS 192
            :.|                .||    .|::.:.|        .:||.:  :.:.|: .|.|.|
Worm   218 MAN----------------NGY----ENKFKMLM--------NSYTFQ--SEIQCV-FDDQAI-- 249

  Fly   193 DRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQL 257
             :..|..:::..|                      ||.     .|..:||.:|.||    .|...
Worm   250 -KNTHVSVILACP----------------------SKS-----KCPELTNRANRRS----HKIYT 282

  Fly   258 DFV----NVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGG 318
            .||    |:..:.   |.||              .::....|.||.:......:|.:..:.:..|
Worm   283 AFVPKSSNIDPKS---YHCV--------------LIINGNTVAEAFLEEADFSTTYYALLIIGAG 330

  Fly   319 LIFIFMTTLFVFY--AIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRI 381
            ||.    |:||..  ::|:..:.||                                   ....:
Worm   331 LIL----TIFVILTKSLRQNNYNKV-----------------------------------STTDV 356

  Fly   382 QKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV---NNAIVAVK 443
            ::.|...|.|.::                           ||.|....:..||:   ...||..:
Worm   357 RETRIEELNNKSK---------------------------LGVGNSSTIYTAEICKTKKCIVIKE 394

  Fly   444 MVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG---------CCSQNGPLYVIVEYAPHGNLK 499
            .|::.|       ..:|::::|.: :|.|||..||         |.:.....::::.|.....|:
Worm   395 SVRKSH-------CTKELKLLKSL-KHPNIITPLGVIVQPEQKTCFNVQIRQHLLLPYYQKTCLE 451

  Fly   500 DFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLV 564
            .:::|..|..|..:........:.|...||..||:..|.|:|..::||......|||:|.||||:
Worm   452 TYIHKFYPPKRGGNNIFHTNEATVPEEEITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLI 516

  Fly   565 SDDYVLKIADFGLARDIQST----------DYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSY 619
            |::.|.||.||..|:..::|          :..:.:.:..:| |....|.|:..:|...|:|:.:
Worm   517 SNNKVCKITDFERAKKGETTRKISIEKKIKEILKAHMSKDIP-KEYPNECLKGVYYYYSSEVYCF 580

  Fly   620 G---ILLWEIM---TYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDR 678
            |   :.|:..|   .|| :.||.|                 :|..|...||.|:..|.:.|...|
Worm   581 GRLMLCLFSFMKPCDYG-RIYPPI-----------------QPENCPKAIYDLIVDCINENRKSR 627

  Fly   679 PPFTE-------IVEYMD-----KLLQTKEDYLDVDI 703
            |..:.       ::::||     ||.||..|.::.:|
Worm   628 PSISSCKDVLSTVLKHMDHDEFLKLKQTLIDEVNRNI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	12/78 (15%)
		IG_like	113..191	CDD:214653	12/77 (16%)
		IG_like	205..289	CDD:214653	16/87 (18%)
		PKc_like	404..692	CDD:304357	76/327 (23%)
		STYKc	416..688	CDD:214568	73/306 (24%)
F59F5.3	NP_509765.2	Pkinase_Tyr	<413..637	CDD:369480	62/242 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810