Protein Alignment htl and F59F5.3

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_509765.2
• Gene: F59F5.3 / 186634
• WormBaseID: WBGene00010342
• Length: 681
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 148/752 - (19%)
• Similarity: 262/752 - (34%)
• Gaps: 254/752 - (33%)

  Fly    10 SHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHL-GARSQNK--TPAITNNANQ 71
            :|:::.:|...:                   |...||.|::|.|: ..|..|.  ...|.:..|.
 Worm   109 THTSVDLTHSKI-------------------RCTRNSIEIMKFHMFVGRDDNMFFKNTIVSKLNG 154

  Fly    72 SS-----TSSADLDDGAADDDDNKADLPVNVSSKPYW----RNPKKMSFLQTRPSGSLLTLNCHA 127
            :.     :.|...::....::....|:|.| ..|.::    |||.. .|.|...:..|::.....
 Worm   155 TGVYLQCSGSYHTENVKLLENQKSLDIPYN-PFKGFYIDISRNPIN-RFYQCEHNDELISFKLQN 217

  Fly   128 LGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVS 192
            :.|                .||    .|::.:.|        .:||.:  :.:.|: .|.|.|
 Worm   218 MAN----------------NGY----ENKFKMLM--------NSYTFQ--SEIQCV-FDDQAI-- 249

  Fly   193 DRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQL 257
             :..|..:::..|                      ||.     .|..:||.:|.||    .|...
 Worm   250 -KNTHVSVILACP----------------------SKS-----KCPELTNRANRRS----HKIYT 282

  Fly   258 DFV----NVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGG 318
            .||    |:..:.   |.||              .::....|.||.:......:|.:..:.:..|
 Worm   283 AFVPKSSNIDPKS---YHCV--------------LIINGNTVAEAFLEEADFSTTYYALLIIGAG 330

  Fly   319 LIFIFMTTLFVFY--AIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRI 381
            ||.    |:||..  ::|:..:.||                                   ....:
 Worm   331 LIL----TIFVILTKSLRQNNYNKV-----------------------------------STTDV 356

  Fly   382 QKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV---NNAIVAVK 443
            ::.|...|.|.::                           ||.|....:..||:   ...||..:
 Worm   357 RETRIEELNNKSK---------------------------LGVGNSSTIYTAEICKTKKCIVIKE 394

  Fly   444 MVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG---------CCSQNGPLYVIVEYAPHGNLK 499
            .|::.|       ..:|::::|.: :|.|||..||         |.:.....::::.|.....|:
 Worm   395 SVRKSH-------CTKELKLLKSL-KHPNIITPLGVIVQPEQKTCFNVQIRQHLLLPYYQKTCLE 451

  Fly   500 DFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLV 564
            .:::|..|..|..:........:.|...||..||:..|.|:|..::||......|||:|.||||:
 Worm   452 TYIHKFYPPKRGGNNIFHTNEATVPEEEITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLI 516

  Fly   565 SDDYVLKIADFGLARDIQST----------DYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSY 619
            |::.|.||.||..|:..::|          :..:.:.:..:| |....|.|:..:|...|:|:.:
 Worm   517 SNNKVCKITDFERAKKGETTRKISIEKKIKEILKAHMSKDIP-KEYPNECLKGVYYYYSSEVYCF 580

  Fly   620 G---ILLWEIM---TYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDR 678
            |   :.|:..|   .|| :.||.|                 :|..|...||.|:..|.:.|...|
 Worm   581 GRLMLCLFSFMKPCDYG-RIYPPI-----------------QPENCPKAIYDLIVDCINENRKSR 627

  Fly   679 PPFTE-------IVEYMD-----KLLQTKEDYLDVDI 703
            |..:.       ::::||     ||.||..|.::.:|
 Worm   628 PSISSCKDVLSTVLKHMDHDEFLKLKQTLIDEVNRNI 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	16/93 (17%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	16/92 (17%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	76/327 (23%)
F59F5.3	NP_509765.2	PK_Tyr_Ser-Thr	<413..637	CDD:462242	62/242 (26%)