DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and ver-4

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_509835.2	Gene:	ver-4 / 186632	WormBaseID:	WBGene00006897	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	890	Identity:	212/890 - (23%)
Similarity:	346/890 - (38%)	Gaps:	281/890 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AAWSWRASHSTI------------------TMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQ-- 47
            |.|| |..:||:                  |.|||..|.| ..|::..|.:::.|...::.|.
Worm   405 AKWS-RLYNSTVEGGQQVETIRNGFFRQITTKTSGRNVFL-ETLNLKSPKIEMSGIYVLSISNMD 467

  Fly    48 ---------EMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYW 103
                     |:..|...|:...:.|...|.:||                   ..||:|.:
Worm   468 IVQQVKWIIEVENDEPNAQLTIRDPLTLNISNQ-------------------LFLPLNTN----- 508

  Fly   104 RNPKKMSFLQTRPSGSLLTLNCHAL-GNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTME----- 162
                             |::.|.|: .:|...|..||....:|.||:...|..:...|.|
Worm   509 -----------------LSIFCLAVSSSPTDVIFEYRTDENEWFRGFYKNKLRKIDDTFEKGFIY 556

  Fly   163 --------------------------------------------------DLV-PGDCGNYTCKV 176
                                                              |:: .||....||.|
Worm   557 NFVLAKRTDFKCINVKKKKTSTKFITVTSNANKTFHEIEKSVNATKTEPSDIIFEGDNVRLTCVV 621

  Fly   177 CNSLGCIRHDT-------QVI----------VSDRVNHKPILMTGPLNL-TLVVNSTGSMHC--- 220
              ..|.:..|.       :::          |.||  :|.::    ||: .:.::.||:.:|
Worm   622 --PYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDR--YKRVI----LNVRNITIDFTGTYYCIVK 678

  Fly   221 ------KYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRME----------QEGW 269
                  ::.:.::.:|.   .|...:.|  |:||||:....|:..:|.::.          ::|:
Worm   679 NKEFEHRFETSISVEKV---SPPFLLNN--NSRSIISASNGQMFDINCKVNGVPTPDYTWFKDGY 738

  Fly   270 -YT--CVESNSLGQSNS----------TAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIF 321
             ||  .|..|:|..|.:          :|..|...::..:|..||..|  |:||.::|:   ..|
Worm   739 PYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGAS--SSSFFWLFI---TFF 798

  Fly   322 IFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRT 386
            .|:....|...:.|:..:|.||                      .|..|::.:.......||...
Worm   799 AFVVVGIVVSLLWKLFGQKDLK----------------------PSELSLNNLKRATDEYQKYTV 841

  Fly   387 TVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNA-----------IV 440
            :...| |.|..........:.::|:...:|.:..|||.|.||.|....:|.|           .|
Worm   842 SEKIN-NLPVEERIDYLTYNEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSV 905

  Fly   441 AVKMVKEGHTDDDIASLVR----EMEVMKIIGRHINIINLLGCCSQN---GPLYVIVEYAPHGNL 498
            |:|    ..||.....|.:    |:::|..|.:|.|:::|:|..::|   |.|:::.|....|||
Worm   906 AIK----SSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNL 966

  Fly   499 KDFLYKNRP-FGRD----------QDRDSSQPPPSPPAHVITEK------------DLIKFAHQI 540
            ::||.:.|. |..:          ..|::     .|...|..|:            ||:....||
Worm   967 REFLRERRDVFANELVEKGYIFLTNVREN-----VPKREVEKEQLLIDEFNSLCTSDLLSIGLQI 1026

  Fly   541 ARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY--RKNTNGRLPIKWMAPE 603
            |.|||:||:..|:|||||.||||:|...:::|||||||:......||  |::.:..||::||..|
Worm  1027 ANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLE 1091

  Fly   604 SLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMR 668
            |:.:..:..|||||||||.|:||.|.|..|||...:. .|..|:.:|...::|:.|..::|.:|:
Worm  1092 SITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNF-SLVEYIKTGNINKRPSNCHKDVYKIMK 1155

  Fly   669 QCWHFNADDRPPFTEIVE--------YMDKLLQTKEDYLDVDIAN 705
            .||..:.||||.|.|.::        :..||||..|..|:.:..|
Worm  1156 MCWQASPDDRPTFAECIKLFKNHIQYFASKLLQQIEKDLECEKNN 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	21/152 (14%)
		IG_like	113..191	CDD:214653	21/151 (14%)
		IG_like	205..289	CDD:214653	23/116 (20%)
		PKc_like	404..692	CDD:304357	109/338 (32%)
		STYKc	416..688	CDD:214568	107/322 (33%)
ver-4	NP_509835.2	ig	609..679	CDD:278476	16/77 (21%)
		IG_like	611..692	CDD:214653	16/88 (18%)
		IG_like	709..782	CDD:214653	13/72 (18%)
		IGc2	714..772	CDD:197706	11/57 (19%)
		STYKc	870..1175	CDD:214568	107/314 (34%)
		PTKc	874..1176	CDD:270623	106/311 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910