Protein Alignment htl and ver-4

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_509835.2
• Gene: ver-4 / 186632
• WormBaseID: WBGene00006897
• Length: 1216
• Species: Caenorhabditis elegans
• Alignment Length: 890
• Identity: 212/890 - (23%)
• Similarity: 346/890 - (38%)
• Gaps: 281/890 - (31%)

  Fly     3 AAWSWRASHSTI------------------TMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQ-- 47
            |.|| |..:||:                  |.|||..|.| ..|::..|.:::.|...::.|.
 Worm   405 AKWS-RLYNSTVEGGQQVETIRNGFFRQITTKTSGRNVFL-ETLNLKSPKIEMSGIYVLSISNMD 467

  Fly    48 ---------EMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYW 103
                     |:..|...|:...:.|...|.:||                   ..||:|.:
 Worm   468 IVQQVKWIIEVENDEPNAQLTIRDPLTLNISNQ-------------------LFLPLNTN----- 508

  Fly   104 RNPKKMSFLQTRPSGSLLTLNCHAL-GNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTME----- 162
                             |::.|.|: .:|...|..||....:|.||:...|..:...|.|
 Worm   509 -----------------LSIFCLAVSSSPTDVIFEYRTDENEWFRGFYKNKLRKIDDTFEKGFIY 556

  Fly   163 --------------------------------------------------DLV-PGDCGNYTCKV 176
                                                              |:: .||....||.|
 Worm   557 NFVLAKRTDFKCINVKKKKTSTKFITVTSNANKTFHEIEKSVNATKTEPSDIIFEGDNVRLTCVV 621

  Fly   177 CNSLGCIRHDT-------QVI----------VSDRVNHKPILMTGPLNL-TLVVNSTGSMHC--- 220
              ..|.:..|.       :::          |.||  :|.::    ||: .:.::.||:.:|
 Worm   622 --PYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDR--YKRVI----LNVRNITIDFTGTYYCIVK 678

  Fly   221 ------KYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRME----------QEGW 269
                  ::.:.::.:|.   .|...:.|  |:||||:....|:..:|.::.          ::|:
 Worm   679 NKEFEHRFETSISVEKV---SPPFLLNN--NSRSIISASNGQMFDINCKVNGVPTPDYTWFKDGY 738

  Fly   270 -YT--CVESNSLGQSNS----------TAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIF 321
             ||  .|..|:|..|.:          :|..|...::..:|..||..|  |:||.::|:   ..|
 Worm   739 PYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGAS--SSSFFWLFI---TFF 798

  Fly   322 IFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRT 386
            .|:....|...:.|:..:|.||                      .|..|::.:.......||...
 Worm   799 AFVVVGIVVSLLWKLFGQKDLK----------------------PSELSLNNLKRATDEYQKYTV 841

  Fly   387 TVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNA-----------IV 440
            :...| |.|..........:.::|:...:|.:..|||.|.||.|....:|.|           .|
 Worm   842 SEKIN-NLPVEERIDYLTYNEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSV 905

  Fly   441 AVKMVKEGHTDDDIASLVR----EMEVMKIIGRHINIINLLGCCSQN---GPLYVIVEYAPHGNL 498
            |:|    ..||.....|.:    |:::|..|.:|.|:::|:|..::|   |.|:::.|....|||
 Worm   906 AIK----SSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNL 966

  Fly   499 KDFLYKNRP-FGRD----------QDRDSSQPPPSPPAHVITEK------------DLIKFAHQI 540
            ::||.:.|. |..:          ..|::     .|...|..|:            ||:....||
 Worm   967 REFLRERRDVFANELVEKGYIFLTNVREN-----VPKREVEKEQLLIDEFNSLCTSDLLSIGLQI 1026

  Fly   541 ARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY--RKNTNGRLPIKWMAPE 603
            |.|||:||:..|:|||||.||||:|...:::|||||||:......||  |::.:..||::||..|
 Worm  1027 ANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLE 1091

  Fly   604 SLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMR 668
            |:.:..:..|||||||||.|:||.|.|..|||...:. .|..|:.:|...::|:.|..::|.:|:
 Worm  1092 SITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNF-SLVEYIKTGNINKRPSNCHKDVYKIMK 1155

  Fly   669 QCWHFNADDRPPFTEIVE--------YMDKLLQTKEDYLDVDIAN 705
            .||..:.||||.|.|.::        :..||||..|..|:.:..|
 Worm  1156 MCWQASPDDRPTFAECIKLFKNHIQYFASKLLQQIEKDLECEKNN 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	21/163 (13%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	23/121 (19%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/7 (29%)
		Ig strand G	282..285	CDD:409353	0/12 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	109/338 (32%)
ver-4	NP_509835.2	IG_like	611..692	CDD:214653	16/88 (18%)
		Ig strand B	615..619	CDD:409353	0/3 (0%)
		Ig strand C	629..633	CDD:409353	1/3 (33%)
		Ig strand E	658..662	CDD:409353	1/7 (14%)
		Ig strand F	672..677	CDD:409353	1/4 (25%)
		Ig	709..782	CDD:472250	13/72 (18%)
		Ig strand B	717..721	CDD:409582	0/3 (0%)
		Ig strand C	730..734	CDD:409582	0/3 (0%)
		Ig strand F	762..767	CDD:409582	0/4 (0%)
		Ig strand G	775..778	CDD:409582	0/2 (0%)
		STYKc	870..1175	CDD:214568	107/314 (34%)