DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Pdgfrb

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001139740.1 Gene:Pdgfrb / 18596 MGIID:97531 Length:1099 Species:Mus musculus


Alignment Length:839 Identity:216/839 - (25%)
Similarity:337/839 - (40%) Gaps:280/839 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 GSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPG--------------- 167
            |..:|:.|..:||...|..|          .|..:|..|....:.|.:.|               
Mouse   227 GESITIRCIVMGNDVVNFQW----------TYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAE 281

  Fly   168 --DCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDL---- 226
              |.|.|||.|           .|.|:|..:.|.|      |::::.|.    :.:.|..|    
Mouse   282 LSDSGTYTCNV-----------SVSVNDHGDEKAI------NISVIENG----YVRLLETLGDVE 325

  Fly   227 --------TSKKAWIFVPCHGMTNCSNNRSI--------------IAEDK--DQLDFVNVRMEQE 267
                    |.:..:...|...:....:||::              ::|.:  .:|..|.|::.:.
Mouse   326 IAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEA 390

  Fly   268 GWYTCVESNSLGQSNSTAYLRV---VRSLHVLEAGVASG-------------------------- 303
            |:||....:...:...:..|:|   ||.|.:.|:..|:|                          
Mouse   391 GYYTMRAFHEDDEVQLSFKLQVNVPVRVLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKS 455

  Fly   304 --------------SLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTK 354
                          |...:.              :.|...|:. ...::|.|...|:..|.|...
Mouse   456 RCPRKLSPTPLGNSSKEESQ--------------LETNVTFWE-EDQEYEVVSTLRLRHVDQPLS 505

  Fly   355 KVIIFKPEGGGDS-----------------SGSMDTMIMPVVRI--------QKQR--------T 386
            ...:.:...||||                 |..:..:::.|:.:        :|.|        .
Mouse   506 VRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQKKPRYEIRWKVIE 570

  Fly   387 TVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKM 444
            :|..:|:|....:..:.|.||.|||||..||||.|||.||||:||.|..:...       |||||
Mouse   571 SVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKM 635

  Fly   445 VKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR--- 506
            :|......:..:|:.|:::|..:|.|:|::||||.|::.||:|:|.||..:|:|.|:|::|:   
Mouse   636 LKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 700

  Fly   507 --------------------PFG-----------------RDQDRDSS----------------- 517
                                |.|                 .|..:|.|                 
Mouse   701 LQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYAD 765

  Fly   518 -QPP----------PSPP-----------AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAAR 560
             :.|          ||.|           :.|::..||:.|::|:|.|||:|||:.|:|||||||
Mouse   766 IESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAAR 830

  Fly   561 NVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625
            |||:.:..::||.||||||||.....|....:..||:|||||||:....|.:.|||||:||||||
Mouse   831 NVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWE 895

  Fly   626 IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690
            |.|.|..|||.:...::.|..:..|.||.:||..|..||.:|::||....:.||||:::|..:::
Mouse   896 IFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLER 960

  Fly   691 LL---------QTKEDYLDVD-------------IANLDTPPSTSD-----EEEDETDN 722
            ||         |..|::|..|             |.:|.:|..||.     .:.:|:||
Mouse   961 LLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDN 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 19/89 (21%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 3/4 (75%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 17/116 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 137/373 (37%)
PdgfrbNP_001139740.1 ig 36..113 CDD:395002
Ig strand B 49..53 CDD:409353
Ig strand C 59..62 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 96..101 CDD:409353
Ig 211..309 CDD:472250 24/108 (22%)
Ig strand B 230..234 CDD:409353 1/3 (33%)
Ig strand C 243..247 CDD:409353 2/13 (15%)
Ig strand E 273..277 CDD:409353 0/3 (0%)
Ig strand F 287..292 CDD:409353 3/4 (75%)
Ig strand G 302..305 CDD:409353 1/2 (50%)
Ig 313..414 CDD:472250 15/104 (14%)
Ig strand B 333..337 CDD:409353 1/3 (33%)
Ig strand C 346..350 CDD:409353 0/3 (0%)
Ig strand E 378..382 CDD:409353 1/3 (33%)
Ig strand F 392..397 CDD:409353 2/4 (50%)
Ig strand G 405..408 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 562..953 CDD:473864 139/390 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1099 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

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