DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Pdgfrb

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001139740.1 Gene:Pdgfrb / 18596 MGIID:97531 Length:1099 Species:Mus musculus


Alignment Length:839 Identity:216/839 - (25%)
Similarity:337/839 - (40%) Gaps:280/839 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 GSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPG--------------- 167
            |..:|:.|..:||...|..|          .|..:|..|....:.|.:.|               
Mouse   227 GESITIRCIVMGNDVVNFQW----------TYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAE 281

  Fly   168 --DCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDL---- 226
              |.|.|||.|           .|.|:|..:.|.|      |::::.|.    :.:.|..|    
Mouse   282 LSDSGTYTCNV-----------SVSVNDHGDEKAI------NISVIE
NG----YVRLLETLGDVE 325

  Fly   227 --------TSKKAWIFVPCHGMTNCSNNRSI--------------IAEDK--DQLDFVNVRMEQE 267
                    |.:..:...|...:....:||::              ::|.:  .:|..|.|::.:.
Mouse   326 IAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEA 390

  Fly   268 GWYTCVESNSLGQSNSTAYLRV---VRSLHVLEAGVASG-------------------------- 303
            |:||....:...:...:..|:|   ||.|.:.|:..|:|                          
Mouse   391 GYYTMRAFHEDDEVQLSFKLQVNVPVRVLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKS 455

  Fly   304 --------------SLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTK 354
                          |...:.              :.|...|:. ...::|.|...|:..|.|...
Mouse   456 RCPRKLSPTPLGNSSKEESQ--------------LETNVTFWE-EDQEYEVVSTLRLRHVDQPLS 505

  Fly   355 KVIIFKPEGGGDS-----------------SGSMDTMIMPVVRI--------QKQR--------T 386
            ...:.:...||||                 |..:..:::.|:.:        :|.|        .
Mouse   506 VRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQKKPRYEIRWKVIE 570

  Fly   387 TVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKM 444
            :|..:|:|....:..:.|.||.|||||..||||.|||.||||:||.|..:...       |||||
Mouse   571 SVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKM 635

  Fly   445 VKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR--- 506
            :|......:..:|:.|:::|..:|.|:|::||||.|::.||:|:|.||..:|:|.|:|::|:   
Mouse   636 LKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 700

  Fly   507 --------------------PFG-----------------RDQDRDSS----------------- 517
                                |.|                 .|..:|.|                 
Mouse   701 LQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYAD 765

  Fly   518 -QPP----------PSPP-----------AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAAR 560
             :.|          ||.|           :.|::..||:.|::|:|.|||:|||:.|:|||||||
Mouse   766 IESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAAR 830

  Fly   561 NVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625
            |||:.:..::||.||||||||.....|....:..||:|||||||:....|.:.|||||:||||||
Mouse   831 NVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWE 895

  Fly   626 IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690
            |.|.|..|||.:...::.|..:..|.||.:||..|..||.:|::||....:.||||:::|..:::
Mouse   896 IFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLER 960

  Fly   691 LL---------QTKEDYLDVD-------------IANLDTPPSTSD-----EEEDETDN 722
            ||         |..|::|..|             |.:|.:|..||.     .:.:|:||
Mouse   961 LLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDN 1019

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 19/89 (21%)
IG_like 113..191 CDD:214653 19/89 (21%)
IG_like 205..289 CDD:214653 16/111 (14%)
PKc_like 404..692 CDD:304357 137/373 (37%)
STYKc 416..688 CDD:214568 129/357 (36%)
PdgfrbNP_001139740.1 ig 36..113 CDD:278476
IG_like 221..309 CDD:214653 24/108 (22%)
Ig 227..311 CDD:299845 24/110 (22%)
Ig 313..414 CDD:299845 15/104 (14%)
IG 334..412 CDD:214652 12/77 (16%)
PKc_like 562..953 CDD:304357 139/390 (36%)
Pkinase_Tyr 600..953 CDD:285015 128/352 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1099 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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