Protein Alignment htl and trk-1

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001360632.1
• Gene: trk-1 / 183575
• WormBaseID: WBGene00017039
• Length: 842
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 175/718 - (24%)
• Similarity: 289/718 - (40%)
• Gaps: 193/718 - (26%)

  Fly    94 PVNVSSKPYWRNPKKMSFLQTRPSGSL--LTLNCHALGNPEPNITWYRNG---TV---------- 143
            |:..|.:..|...|::....|.|. ||  ...||.......|.:.:.:||   ||
 Worm   125 PIQCSCQNQWMRAKEIFEKITEPK-SLRKCAWNCDPGKMMFPGVIYSKNGDNVTVHVGFDDQVLN 188

  Fly   144 --------DWT--------------RGYGSLKRNRWTLTMEDL--VPGDC--------------G 170
                    ||.              :|...:..|   |..||:  :...|              .
 Worm   189 RTIDKPYFDWAFSKHPHKHEEIIAEKGADLMITN---LKREDMGVIGVKCWHCLDFLVGKIELRA 250

  Fly   171 NYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PL-NLTLVVNSTGSMHCKYLSDLTSKKAWI 233
            ||..||. .:...|.||..:|          :|| |: |:::.:.   .|...|
 Worm   251 NYPVKVA-FVDKTRLDTDFLV----------VTGYPIDNISMAIT---KMQSNY----------- 290

  Fly   234 FVPCHGMTNCSNNRSIIAEDKDQLDFVN--VRMEQ-----EGWYTCVESNSLGQSNSTAYLRV-- 289
                       :..:.:..:||.:.|.:  ||||:     :..|.....::....:.:..||.
 Worm   291 -----------SETNFVGREKDAIFFSSLVVRMEKRPLFYQKTYRVFTKDAAEGDHLSGDLRFEV 344

  Fly   290 -------VRSLHVLEAGVASGSLHSTSFV--------YIFVFGGLIFI---FMTTLFVFYAIRKM 336
                   ....||...|:.:|::.....|        .|.||  ||.|   .:.:...||...|:
 Worm   345 CTNGSCDAIEKHVSHLGLINGTIDDFIIVEYPYKQEIQIVVF--LIVICLLIVVSALAFYHRLKL 407

  Fly   337 K---HEKVL--KQRIETVHQ-WTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP 395
            :   .||:|  ::||....: .|::.          |..:.:|::    |::::.:......|..
 Worm   408 QSFLREKILSFRKRISLAQELQTRRA----------SQETEETLL----RLEERSSLASDYTNMT 458

  Fly   396 APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE---VNNAIVAVKMVKEGHTDDDIASL 457
            .||            :...::.:...||:|.||.|.:|.   .....||||.::.    .|:|:
 Worm   459 LPF------------IDMGNIEIHEMLGKGHFGEVYLASWDYTGPRSVAVKSIRR----VDMAT- 506

  Fly   458 VREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPS 522
            .:|..|::.: .|.||:.|.|....|..|.::.|:..||:||.:|.:..|.       .|.....
 Worm   507 EKEARVLQDL-EHPNIVKLYGMTRNNFNLLLVFEHMNHGDLKTYLEQRAPV-------KSVYLQY 563

  Fly   523 PPAHVITE-KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVL-------------KIA 573
            ||..||.| |.:||   :|..|:.||..:..:||||||||.||:.|..|             ||:
 Worm   564 PPPLVIDELKWIIK---EITTGLVYLVEQSIVHRDLAARNCLVAGDSDLKATSHFERPPIRVKIS 625

  Fly   574 DFGLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTI 637
            |||::|.: ..::||..:..|.||::|:.||::|...:...||:||.|:.:||.|:||:||:..
 Worm   626 DFGMSRRLYDHSEYYTMDHRGALPVRWLPPEAVQSHKFTYNSDIWSLGVTMWECMSYGRQPFDG- 689

  Fly   638 MSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVD 702
            :|..|:.::.::|.|..||.:|..::|.||.:|||.....|....:|:|  |:|.....:.|...
 Worm   690 LSNLEVSSFTLAGMRPLKPERCPQDMYDLMVKCWHMEPVKRITAKQILE--DELFDKIREGLPYR 752

  Fly   703 IAN 705
            .||
 Worm   753 AAN 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	28/142 (20%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	15/97 (15%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	98/305 (32%)
trk-1	NP_001360632.1	PTKc	471..738	CDD:270623	96/283 (34%)