Protein Alignment htl and C25A8.5

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_501081.1
• Gene: C25A8.5 / 182879
• WormBaseID: WBGene00016085
• Length: 416
• Species: Caenorhabditis elegans
• Alignment Length: 405
• Identity: 122/405 - (30%)
• Similarity: 190/405 - (46%)
• Gaps: 74/405 - (18%)

  Fly   331 YAIRKMKHE-------KVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIM----PVVRIQKQ 384
            |.:..|:.|       |....|:...:|      ||....|.::..|:....|    |:.::...
 Worm    46 YVLSAMQSEELEDAGVKHYVMRLNPSNQ------IFLEAKGFETIASLVNYYMNSKEPIKKMTVL 104

  Fly   385 RTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE--VNNAIV---AVKM 444
            :|.:|:   :|             ||:..|.:.|...|||||||.|...:  :.|..|   |:|.
 Worm   105 KTPILK---QP-------------WEIEHSQVELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKT 153

  Fly   445 VK-EGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPF 508
            .| |....:.|..::||..:|:.:. |.|::...|..:...|||||:|.|..|.|..:|.||
 Worm   154 AKLESLNKEQIKEIMREARLMRNLD-HPNVVKFYGVGASQEPLYVIMELADCGALDSYLQKN--- 214

  Fly   509 GRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIA 573
                            .:::..|.: :..:|.|.|:.|:..::.:|||:||||.|..:..| |||
 Worm   215 ----------------PNLLPGKKM-EMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQV-KIA 261

  Fly   574 DFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM 638
            ||||:|:..|   |..:...::||:|:|||:|:...|..||||:::||:.|||...|::|||. |
 Worm   262 DFGLSREGNS---YVMDLTKKVPIRWLAPETLKAGIYSPKSDVFAFGIMAWEITENGKEPYPD-M 322

  Fly   639 SAEELYTYLMSGQRME-KPAKCSMNI--YILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLD 700
            ...|:..|:.||.||. .|.......  |: .:.||..|.|||...::::.|    |||......
 Worm   323 RVSEVVGYVRSGHRMRFDPVFVDFRFGEYV-TKHCWAENPDDRVNMSDVLRY----LQTTFGMKP 382

  Fly   701 VDIANLDTPPSTSDE 715
            | |.:|....:|.||
 Worm   383 V-ILSLRNRTTTDDE 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	98/296 (33%)
C25A8.5	NP_501081.1	SH2_Fps_family	4..98	CDD:198224	11/57 (19%)
		PTKc	124..375	CDD:270623	94/281 (33%)