DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and ver-3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_509836.1	Gene:	ver-3 / 181289	WormBaseID:	WBGene00006896	Length:	1227	Species:	Caenorhabditis elegans

Alignment Length:	721	Identity:	177/721 - (24%)
Similarity:	298/721 - (41%)	Gaps:	172/721 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SSKPYWRNPKKMSFLQTRPSGSLLTLNC-HALGNPEPNITW-YRNGTVDWTRGYGSLKRNRWT-- 158
            |||.....|.|:.:     .|..:.|.| ..|.:.:.:::| :.|..   :....|:.....|
Worm   570 SSKATESEPSKIIY-----EGDNVKLTCVFPLDSDDWSVSWRFENSK---SSDISSIPTTTETEI 626

  Fly   159 --------LTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVN----HKPILMTGPLNLTLV 211
                    |.:.|:.....|.|||.|.|      .|::.::...::    .||.:..|..|..::
Worm   627 KQYSKHLILNLRDVTTSFTGTYTCVVKN------EDSEKLLETSIDVKAISKPSITGGNSNAVVI 685

  Fly   212 V----------NSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQ 266
            |          |.||:....|        .| |...:..|:...:.||:...:       .|.|.
Worm   686 VDYDQYFEINCNMTGTPPPVY--------QW-FKDGNPYTHGDVDGSILRVSR-------ARGED 734

  Fly   267 EGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFY 331
            :|.:.|:.:|..|..        :.|:.|.......|||....|:.:.:...:|.:|:.|..:..
Worm   735 DGEFHCLATNRAGDK--------LNSIEVQVNNAPKGSLFFYWFLALLLLISIIAVFLLTCKLRA 791

  Fly   332 AIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPA 396
            :.|..|.:.:   .:.|::                     :|||       |.:...|....:..
Worm   792 SNRLTKQKDI---ALNTLY---------------------ETMI-------KHQAGPLPEEMKDL 825

  Fly   397 PFNE--YEFPLDSNWELPRSHLVLGATLGEGAFGRVV-----MAEVNNAI-------VAVKMVKE 447
            |..|  |..|.::::|:...:|.:...:|.|.||.|.     ||...:.|       ||||....
Worm   826 PVEERTYYLPYNNDYEIDPVNLEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTN 890

  Fly   448 GHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN---GPLYVIVEYAPHGNLKDFLYKNR-PF 508
            ....:....:..|::||..|.::.|::.|:|..::|   |.||::.|:...|||::||..:| .|
Worm   891 PFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTF 955

  Fly   509 GRDQDRDSSQP-------PPS----------------------PPAHVITEKDLIKFAHQIARGM 544
            ..:...|...|       |.|                      |.|  :...||:....|||:||
Worm   956 INELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDA--LCTSDLLSIGLQIAKGM 1018

  Fly   545 DYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYR--KNTNGRLPIKWMAPESLQE 607
            .:||...|:|||||.||||::...:::||||||::...:..|||  |:.:..||::||..|.::|
Worm  1019 AWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIEE 1083

  Fly   608 KFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWH 672
            ..:..||||||:||.|:||.|.|..|||. .....:..::.:|.|.::|..|...||.||:.||.
Worm  1084 FKFTQKSDVWSFGICLYEIFTLGGTPYPN-CDTFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQ 1147

  Fly   673 FNADDRPPF---------------TEIVEYMDKLLQTK-------EDYLD---VDIANLDTPPST 712
            ||..|||.|               ::.:|.::.:|.|:       :|::.   .|:.|:....|.
Worm  1148 FNPKDRPTFNDCITFFENHMRDSSSQFLERVENMLHTEMQEQSKLDDWIQDSRPDVPNVSFQKSP 1212

  Fly   713 SDEEED 718
            ..::|:
Worm  1213 KKQKEE 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	17/90 (19%)
		IG_like	113..191	CDD:214653	17/89 (19%)
		IG_like	205..289	CDD:214653	17/93 (18%)
		PKc_like	404..692	CDD:304357	108/349 (31%)
		STYKc	416..688	CDD:214568	106/333 (32%)
ver-3	NP_509836.1	IG	242..>313	CDD:214652
		IG_like	578..667	CDD:214653	19/102 (19%)
		Ig_3	578..654	CDD:290638	17/83 (20%)
		I-set	673..757	CDD:254352	21/107 (20%)
		IGc2	692..747	CDD:197706	14/70 (20%)
		STYKc	847..1163	CDD:214568	105/318 (33%)
		PTKc	851..1164	CDD:270623	104/315 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910