Protein Alignment htl and hir-1

DIOPT Version :9

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_504458.1
• Gene: hir-1 / 178936
• WormBaseID: WBGene00016059
• Length: 903
• Species: Caenorhabditis elegans
• Alignment Length: 831
• Identity: 191/831 - (22%)
• Similarity: 325/831 - (39%)
• Gaps: 227/831 - (27%)

  Fly    31 WQP---AVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDD---DN 89
            |.|   ||......:..||:....|.. ..::.:|..::...|....|..::...|..:|   :.
 Worm   100 WSPVPGAVMYYIGYRTLNSKTFTSDDF-VITEKQTVDLSTLTNIDPCSELEVAVAAFSEDGIGNE 163

  Fly    90 KADLPVNVSSKPYWRNPK----KMSFLQTRPSGSLLTLNC------------------------- 125
            ..:|.:: |.|| ..|||    ::.:|.|.........|.
 Worm   164 SKELKIS-SPKP-TANPKLDLLELQYLNTTLVSDFYQANATVHVEFRYKTDPWFLGPDDLDVQPL 226

  Fly   126 -HALGNPEPNIT----------WYRNGTVDWTRGYGSLKRN-RWTLTMEDLVPGDCGNYT----- 173
             |.:...:|:::          ..:|.|:..:.|...:.|. |:...::.::...|...|
 Worm   227 FHLISCVDPDLSQGIPVPDFDVHVKNSTISTSIGSDMMDRKCRYVYYLQSVMSKKCNTMTEMPSP 291

  Fly   174 -----------CKVCNSLGCIRHDT--------------QVIVSDRVNHKPILMTGPLNLTLV-V 212
                       |.:..:..|::..:              .|:..||.|.........:|:|.: |
 Worm   292 PSSALQTIQVECDIVKNAPCVKVPSYQPPLCGMVENVAFSVLSRDRENLNDPASNLTVNVTFIPV 356

  Fly   213 NSTGSMHCKY-------LSDLTSKKAWIFV------------PCHGMTNCSN------NRSII-- 250
            .....|...|       .|:..:|:...|:            .|.|..:..|      ||||:
 Worm   357 TRNNEMPTLYYIGIFGTASEYHTKEEETFLGVNITHVIGKESSCTGFDSSGNCLAENLNRSIVLQ 421

  Fly   251 --------------AEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVA 301
                          .:|...|...:|.::.:.:....:...|                     ||
 Worm   422 GIHPKTLYGLTICAVKDIRNLTLPDVTLDSKSFRAKADRIML---------------------VA 465

  Fly   302 SGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGD 366
            ..|.:....:...|.|.|:.|.:..:.:::..||.......|.::|.|               |.
 Worm   466 HTSNNPVGMIIGIVIGSLVVILVAIVVIWFYFRKKSENMKFKFQMEQV---------------GK 515

  Fly   367 SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEY-EFPL----DSNWELPRSHLVL--GATLGE 424
            ::                             .|.| :||:    :..||:.|.:|::  ...||.
 Worm   516 NN-----------------------------MNRYIDFPIMAAKNDIWEIERRNLIIHNDKKLGS 551

  Fly   425 GAFGRVVMAEV---------------------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIG 468
            ||||.|.:.::                     .|..|||||:.|...:......:||:.:||.:|
 Worm   552 GAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKMLPEYADEMSKHEFLREIALMKTLG 616

  Fly   469 RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAH------- 526
            .|..::|:|.|.:::.||.::|||..:|:|..||.:...:....| |.......||.:
 Worm   617 YHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERCKYMMKLD-DLGINYHDPPENENYDTNM 680

  Fly   527 VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT 591
            ::|.|.|::||.||:.|::||:.:..:|||:|||||||.:....||.||||.|.|.:.....|:.
 Worm   681 IVTLKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKSK 745

  Fly   592 NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKP 656
            .|:||:|||:||:::...:..|||:||:||||:|::|.|..|||. |..|::..:|..|.|:|||
 Worm   746 GGKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGSPYPG-MPPEDVLPFLEGGGRIEKP 809

  Fly   657 AKCSMNIYILMRQCWHFNADDRPPFTEI-VEYMDKLLQTKED--YLDVDIA 704
            ..|..|.|.:|.|||:.:.|||..|::: ::...:|....||  ||.:|.|
 Worm   810 DNCPENFYDVMMQCWNADPDDRIEFSDVRMQLATQLEDITEDYSYLKLDAA 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	15/145 (10%)
		IG_like	113..191	CDD:214653	14/144 (10%)
		IG_like	205..289	CDD:214653	19/125 (15%)
		PKc_like	404..692	CDD:304357	112/322 (35%)
		STYKc	416..688	CDD:214568	108/302 (36%)
hir-1	NP_504458.1	fn3	85..163	CDD:365830	12/63 (19%)
		PTKc	547..842	CDD:270623	107/296 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910