DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and kin-16

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_496017.1	Gene:	kin-16 / 174499	WormBaseID:	WBGene00002200	Length:	495	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	141/458 - (30%)
Similarity:	212/458 - (46%)	Gaps:	86/458 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 GSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMK-HEKVLKQRIETVHQWTKKVIIFKPEGGGD 366
            ||:........||..||:.:.....|:.:.:|:.| .||.....:..::...:..        ||
Worm    53 GSVFKLRTTVFFVVYGLLVLLAFIAFLVWRLRRSKTQEKRKNMALMNIYSDLRDT--------GD 109

  Fly   367 SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN---EYEFPLDSNWELPRSHLVLGATLGEGAFG 428
            :        ||         ..|:|    .|.|   :| .|....:|:...:|...:.||.|.||
Worm   110 A--------MP---------EELKN----RPLNDKLDY-LPYKKQYEIASENLENKSILGSGNFG 152

  Fly   429 RV-----VMAEVNN-------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS 481
            .|     .||...|       ..||||.....:.....:.|..|:.:|..|||..|::.|:|..:
Worm   153 VVRKGILKMASPKNEEEKKMRLTVAVKSAANCYDISQTSMLAAELRLMCSIGRFPNVLALVGAVT 217

  Fly   482 ---QNGPLYVIVEYAPHGNLKDFLYKNRPFGRD---QDR---DSSQPPPSPPA------------ 525
               :.|.|.::.||...|:::.:|..:|...:|   :|:   ||...|.|...
Worm   218 SELRKGRLLIVTEYIDCGDIRKYLIDHRNVFQDHLIEDKTEPDSYLTPISAKRKNYVFKNTDENS 282

  Fly   526 -HVI-------TEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQ 582
             :||       |..||:.|..|||.||.||||...:|||||.||||:..:..::|||||:||..:
Worm   283 DYVIKESLDSLTTSDLLSFGLQIANGMQYLASIPMVHRDLALRNVLLKKNKTIRIADFGMARTHE 347

  Fly   583 STDYY--RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYT 645
            :..||  :|..:..:|::||:||:.....:..||||||:||.|:||.|.||.|||.:.| |.:|.
Worm   348 NKSYYIPQKTKDAPVPVRWMSPEAFDTMKFTEKSDVWSFGICLYEIFTLGQLPYPDVPS-ERIYE 411

  Fly   646 YLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM--------DKLLQTKEDYLDVD 702
            |:.||:|..:|..|.:.:|.||:.|||...:.||.|:..|||.        .|||:..::.|.|:
Worm   412 YMHSGRRCPQPQHCHVELYDLMKLCWHEKPELRPNFSNCVEYFIGHMKKSASKLLENVDEMLRVE 476

  Fly   703 IAN 705
            ..|
Worm   477 AEN 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	116/338 (34%)
		STYKc	416..688	CDD:214568	112/314 (36%)
kin-16	NP_496017.1	STYKc	140..454	CDD:214568	112/314 (36%)
kin-16	NP_496017.1	PTKc	145..454	CDD:270623	111/309 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910