DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and B0252.1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_495419.2	Gene:	B0252.1 / 174133	WormBaseID:	WBGene00015087	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	128/483 - (26%)
Similarity:	211/483 - (43%)	Gaps:	67/483 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 WIFV---PCHGMTNCSNN-------RSIIAEDKDQL--DF----VNVRMEQEGWYTCVESNSLG- 279
            ::||   .|...||.:.|       |.::.||.:.:  ||    ||:....:.....|..|.:.
Worm   343 YLFVGNAECATTTNLTTNIKDSTHIRLVMDEDLNDVYEDFTLPLVNLGFLDKTVDNQVIHNDMFY 407

  Fly   280 -QSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGL-IFIFMTTLFVFYAIRKMKH-EKV 341
             |:.||:....:..:.:|.|    ...|...::.|.:...| |||..|.....:.|...:| .:.
Worm   408 LQNYSTSCTDEIPMVPLLSA----RPWHRPKYLSIALDDMLTIFICATISVTTFGILIYRHVSRK 468

  Fly   342 LKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLD 406
            .:|::|.:                     .:.|:.|  ||.|......:....|.........:|
Worm   469 HRQQVELL---------------------SELMLQP--RIYKAPKECAKVARLPWEIKSENVHID 510

  Fly   407 SNWELPR---SHLVLGATLGEGA----FGRVVMAEVNNAIVAVKMVKEGHTDD-DIASLVREMEV 463
            ..:.|..   |::.||...|:..    ..||.|.:..:..|||::  ..|.|: :...|.||:..
Worm   511 KEFLLGEGTISNVYLGKLKGKSPIMQWIDRVEMKQYQDCAVAVRV--PSHFDEPEEDQLQREIAS 573

  Fly   464 MKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSP-PAHV 527
            |:.:..|.:|..|||..::|..:..::|.. |.||..:|.:.|... :||..|...|.|. |..|
Worm   574 MRQLRHHDHIALLLGWTNKNDLVCSLLELT-HMNLIKYLSQIRETA-EQDNSSGFTPMSRIPFQV 636

  Fly   528 ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTN 592
                 |.|..::|..|::|:.||..:||||.|||||::.....||:.||...:.....:...:..
Worm   637 -----LYKIIYEICDGIEYIHSRNLVHRDLTARNVLLTTGLRAKISGFGFCSEPDDPKFAANSLA 696

  Fly   593 GR-LPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKP 656
            .| ||::|:|||....|| ..|||.||:|:|::|:.:.|:|||..::..||:...:..|:....|
Worm   697 LRYLPVRWLAPECFIGKF-SVKSDSWSFGVLMYEMFSLGEQPYEDLIRPEEIIESIRKGRVPAHP 760

  Fly   657 AKCSMNIYILMRQCWHFNADDRPPFTEI 684
            ..||...|.:|:.|:......||.||::
Worm   761 KYCSKQTYKIMQSCYQSFMSRRPNFTQL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	18/74 (24%)
		PKc_like	404..692	CDD:304357	91/291 (31%)
		STYKc	416..688	CDD:214568	88/276 (32%)
B0252.1	NP_495419.2	PKc_like	515..792	CDD:389743	90/284 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810