Protein Alignment htl and src-2

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_493502.1
• Gene: src-2 / 173296
• WormBaseID: WBGene00005078
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 382
• Identity: 125/382 - (32%)
• Similarity: 189/382 - (49%)
• Gaps: 61/382 - (15%)

  Fly   331 YAIRKMKHEK--VLKQR-IETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNG 392
            |.||::.|..  :.::| ..|:|.   .:..::.|    :.|....:..|..:.:..:||.
 Worm   173 YRIRQLDHGGYFIARRRPFATLHD---LIAHYQRE----ADGLCVNLGAPCAKSEAPQTTT---- 226

  Fly   393 NEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN-NAIVAVKMVKEGHTDDDIAS 456
                      |..|..||:.|..:.|...:|.|.||.|.....| |..||||.:|.|..|.  ..
 Worm   227 ----------FTYDDQWEVDRRSVRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADP--TD 279

  Fly   457 LVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPP 521
            .:.|.::||.: ||..:::|...|:::.|:.::.|.... ||..||.:       :.|....|
 Worm   280 FLAEAQIMKKL-RHPKLLSLYAVCTRDEPILIVTELMQE-NLLTFLQR-------RGRQCQMP-- 333

  Fly   522 SPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDY 586
                      .|::.:.|:|.||.||.....|||||||||:|:::...:|||||||||.:...:.
 Worm   334 ----------QLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENE 388

  Fly   587 YRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQ 651
            |...|..|.||||.|||:.....:.:||||||:||||.||:|:|:.|||.:.:||.| ..:.:|.
 Worm   389 YEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVL-QQVDAGY 452

  Fly   652 RMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDT 708
            ||..||.|.:.:|.:|:|||..:.|.||.|        :.||.|.:    |:.|||:
 Worm   453 RMPCPAGCPVTLYDIMQQCWRSDPDKRPTF--------ETLQWKLE----DLFNLDS 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	105/288 (36%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779
		SH2_Src_Src42	120..215	CDD:198233	9/48 (19%)
		PTKc_Frk_like	231..496	CDD:270653	109/300 (36%)