DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Met

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_032617.2 Gene:Met / 17295 MGIID:96969 Length:1379 Species:Mus musculus


Alignment Length:488 Identity:146/488 - (29%)
Similarity:244/488 - (50%) Gaps:100/488 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 WYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAI 333
            |...|.|..||        :|:.......||:..|:: |.|.|.:.:.|  :|::|         
Mouse   910 WKQAVSSTVLG--------KVIVQPDQNFAGLIIGAV-SISVVVLLLSG--LFLWM--------- 954

  Fly   334 RKMKHEKVLKQ------RIETVH---------------QWTKKVIIFK---PEG---GGDSSGSM 371
            ||.||:.:..:      |:.|.|               ..:.:.:.::   ||.   ....:|:.
Mouse   955 RKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGAC 1019

  Fly   372 DTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDS-NWELPRS--HLVLGAT---------LGE 424
            ..:..|:..:....|:...:.:.|...|.....|.: |.||.::  |:|:|.:         :|.
Mouse  1020 RQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGR 1084

  Fly   425 GAFGRVVMA--------EVNNAIVAVKMVKEGHTD-DDIASLVREMEVMKIIGRHINIINLLGCC 480
            |.||.|...        :::.|:.::..:    || ::::..:.|..:||... |.|:::|||.|
Mouse  1085 GHFGCVYHGTLLDNDGKKIHCAVKSLNRI----TDIEEVSQFLTEGIIMKDFS-HPNVLSLLGIC 1144

  Fly   481 --SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARG 543
              |:..|| |::.|..||:|::|:           |:.:..|        |.||||.|..|:|:|
Mouse  1145 LRSEGSPL-VVLPYMKHGDLRNFI-----------RNETHNP--------TVKDLIGFGLQVAKG 1189

  Fly   544 MDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY--RKNTNGRLPIKWMAPESLQ 606
            |.||||::.:||||||||.::.:.:.:|:||||||||:...:||  ...|..:||:||||.||||
Mouse  1190 MKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQ 1254

  Fly   607 EKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCW 671
            .:.:.:||||||:|:||||:||.|..|||.: :..::..||:.|:|:.:|..|...:|.:|.:||
Mouse  1255 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITIYLLQGRRLLQPEYCPDALYEVMLKCW 1318

  Fly   672 HFNADDRPPFTEIVEYMDKLLQT--KEDYLDVD 702
            |..|:.||.|:|:|..:..:..|  .|.|:.|:
Mouse  1319 HPKAEMRPSFSELVSRISSIFSTFIGEHYVHVN 1351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 5/19 (26%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 113/312 (36%)
MetNP_032617.2 Sema 25..515 CDD:472829
PSI 518..560 CDD:214655
IPT_plexin_repeat1 562..655 CDD:238585
IPT_plexin_repeat2 656..739 CDD:238584
IPT 741..836 CDD:472823
IPT_PCSR 838..917 CDD:238337 2/6 (33%)
PTKc_Met_Ron 1080..1341 CDD:270649 106/286 (37%)
Interaction with RANBP9. /evidence=ECO:0000250 1210..1379 60/143 (42%)
Interaction with MUC20. /evidence=ECO:0000250 1318..1357 12/34 (35%)
Blue background indicates that the domain is not in the aligned region.

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