Protein Alignment htl and Kit

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001116205.1
• Gene: Kit / 16590
• MGIID: 96677
• Length: 979
• Species: Mus musculus
• Alignment Length: 169
• Identity: 27/169 - (15%)
• Similarity: 58/169 - (34%)
• Gaps: 42/169 - (24%)

  Fly   263 LQNDAKKIALQITLLNNNRDIEEDDISILSWHEILGFSAPTHTDEKKTWKTLFKST--RFLKPTA 325
            |.||.|...|:.::..::         :.:||:                 .||:|:  .|:...:
Mouse   294 LPNDGKMKELEESICRHH---------LKNWHD-----------------KLFRSSVDLFMPKFS 332

  Fly   326 VMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLC 390
            :...|.:...::..|...:.|       |.....|:.:.:    ...::|.|.:..:::...|
Mouse   333 ISATSKLDDILMDMGMTDAFD-------YKADFSGMTEEV----KVRVSRVLHQAVMSVDEKG-- 384

  Fly   391 CLAALMILPIQYYDIQCMRWVIIMLSLMIAAGIDPTWKI 429
             ..|..|..|:...:.....||:....::....|.|..|
Mouse   385 -TEAAAITTIEIMPMSLPHTVILNRPFLVLIVEDSTMSI 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	5/25 (20%)
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	5/26 (19%)
Kit	NP_001116205.1	ig	217..308	CDD:395002	5/13 (38%)
		Ig strand B	230..234	CDD:409353
		Ig strand C	244..248	CDD:409353
		Ig strand E	276..280	CDD:409353
		Ig strand G	300..306	CDD:409353	1/5 (20%)
		IgI_4_SCFR	314..414	CDD:409446	19/130 (15%)
		Ig strand A	314..320	CDD:409446	2/22 (9%)
		Ig strand A'	324..329	CDD:409446	1/4 (25%)
		Ig strand B	332..342	CDD:409446	1/9 (11%)
		Ig strand C	346..353	CDD:409446	1/6 (17%)
		Ig strand C'	355..358	CDD:409446	0/2 (0%)
		Ig strand D	361..366	CDD:409446	0/8 (0%)
		Ig strand E	375..384	CDD:409446	0/8 (0%)
		Ig strand F	391..399	CDD:409446	1/7 (14%)
		Ig strand G	402..413	CDD:409446	2/10 (20%)
		Ig	429..505	CDD:409353
		Ig strand C	440..444	CDD:409353
		Ig strand E	473..481	CDD:409353
		Ig strand F	491..496	CDD:409353
		PTKc_Kit	556..930	CDD:270682
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573