DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Kdr

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_034742.2 Gene:Kdr / 16542 MGIID:96683 Length:1345 Species:Mus musculus


Alignment Length:812 Identity:233/812 - (28%)
Similarity:347/812 - (42%) Gaps:208/812 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 WQPAVQVEGRRQMANSQEMIKDHLG-ARSQNKTPA--ITNNANQSSTSSADLDDGAADDDDNKAD 92
            |:.....:|    .|..|:.|:... ...:|||.:  :...||.|:....:.        .|||.
Mouse   483 WRHVEDFQG----GNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEA--------INKAG 535

  Fly    93 LPVNVSSKPYWRNPKKMSFLQTRPSG-----SLLTLNCHALGNPEPNITWYRNG----TVDWTRG 148
            ....|.|....|.|:    :..:|:.     ..::|.|.|..|...|:|||:.|    :|.....
Mouse   536 RGERVISFHVIRGPE----ITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGES 596

  Fly   149 YGSLKRN---RWTL--------TMEDLVPG-------DCGNYTCKVCNSLGCIRH--DTQVIVSD 193
            ...:.:|   .|.|        |.:.|:..       |.|:|.|...:.....||  ..|:|:.:
Mouse   597 LTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIILE 661

  Fly   194 RVNHKPILMTGPL-NLTLVVNSTGSMHCKYLSDLTSKKAWI-----FVPCHGMTNCSNNRSIIAE 252
            |:  .| ::||.| |.|..:..|..:.|....:.|....|.     .|...|:.....||:    
Mouse   662 RM--AP-MITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRN---- 719

  Fly   253 DKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFG 317
                |....||.|..|.|||...|.||.:.:       .:|.::|     |:...|:...|.:.|
Mouse   720 ----LTIRRVRKEDGGLYTCQACNVLGCARA-------ETLFIIE-----GAQEKTNLEVIILVG 768

  Fly   318 GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQ 382
            ..:......|.:...:|.:|..                           :.|.:.|..:.:|   
Mouse   769 TAVIAMFFWLLLVIVLRTVKRA---------------------------NEGELKTGYLSIV--- 803

  Fly   383 KQRTTVLQNGNEPAPFNEYEFPLD----------SNWELPRSHLVLGATLGEGAFGRVVMAE--- 434
                           .:..|.|||          |.||.||..|.||..||.||||:|:.|:   
Mouse   804 ---------------MDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFG 853

  Fly   435 ----VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAP 494
                .....|||||:|||.|..:..:|:.|::::..||.|:|::||||.|:: .|||.||||:..
Mouse   854 IDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 918

  Fly   495 HGNLKDFL---------YKNRPFGRDQDRD-----------------SSQPPPSPPAHVITEKD- 532
            .|||..:|         ||::.....|.:|                 |||  .|..:..:.||. 
Mouse   919 FGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQ--SSASSGFVEEKSL 981

  Fly   533 ---------------------LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
                                 ||.::.|:|:||::||||:||||||||||:|:|:..|:||.|||
Mouse   982 SDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFG 1046

  Fly   577 LARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSA 640
            ||||| :..||.||. :.|||:||||||::.::.|..:|||||:|:|||||.:.|..|||.:...
Mouse  1047 LARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID 1110

  Fly   641 EELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK-----EDYLD 700
            ||....|..|.||..|...:..:|..|..|||.:.:.||.|:|:||::..|||..     :||:.
Mouse  1111 EEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGNLLQANAQQDGKDYIV 1175

  Fly   701 VDIA-----------NLDTPPSTSDEEEDETD 721
            :.::           :|.|.|.:..|||:..|
Mouse  1176 LPMSETLSMEEDSGLSLPTSPVSCMEEEEVCD 1207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 23/107 (21%)
IG_like 113..191 CDD:214653 23/106 (22%)
IG_like 205..289 CDD:214653 22/89 (25%)
PKc_like 404..692 CDD:304357 140/354 (40%)
STYKc 416..688 CDD:214568 132/328 (40%)
KdrNP_034742.2 Ig_3 31..105 CDD:404760
Ig 226..327 CDD:416386
Ig strand A 226..230 CDD:409353
Ig strand A' 236..240 CDD:409353
Ig strand B 242..251 CDD:409353
Ig strand C 258..263 CDD:409353
Ig strand C' 266..268 CDD:409353
Ig strand D 272..280 CDD:409353
Ig strand E 288..296 CDD:409353
Ig strand F 306..312 CDD:409353
Ig strand G 317..323 CDD:409353
Ig 331..419 CDD:416386
Ig strand A 331..334 CDD:409353
Ig strand A' 341..345 CDD:409353
Ig strand B 347..358 CDD:409353
Ig strand C 362..368 CDD:409353
Ig strand C' 370..373 CDD:409353
Ig strand D 378..381 CDD:409353
Ig strand E 383..388 CDD:409353
Ig strand F 396..404 CDD:409353
Ig strand G 410..419 CDD:409353
Ig_3 549..643 CDD:404760 21/97 (22%)
I-set 665..742 CDD:400151 23/85 (27%)
Ig strand B 682..686 CDD:409353 0/3 (0%)
Ig strand C 695..699 CDD:409353 0/3 (0%)
Ig strand E 718..722 CDD:409353 2/11 (18%)
Ig strand F 732..737 CDD:409353 3/4 (75%)
VEGFR-2_TMD 757..791 CDD:375470 6/60 (10%)
PTKc_VEGFR2 824..1165 CDD:270681 139/343 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1272..1316
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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