Protein Alignment htl and Kdr

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_034742.2
• Gene: Kdr / 16542
• MGIID: 96683
• Length: 1345
• Species: Mus musculus
• Alignment Length: 812
• Identity: 233/812 - (28%)
• Similarity: 347/812 - (42%)
• Gaps: 208/812 - (25%)

  Fly    31 WQPAVQVEGRRQMANSQEMIKDHLG-ARSQNKTPA--ITNNANQSSTSSADLDDGAADDDDNKAD 92
            |:.....:|    .|..|:.|:... ...:|||.:  :...||.|:....:.        .|||.
Mouse   483 WRHVEDFQG----GNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEA--------INKAG 535

  Fly    93 LPVNVSSKPYWRNPKKMSFLQTRPSG-----SLLTLNCHALGNPEPNITWYRNG----TVDWTRG 148
            ....|.|....|.|:    :..:|:.     ..::|.|.|..|...|:|||:.|    :|.....
Mouse   536 RGERVISFHVIRGPE----ITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGES 596

  Fly   149 YGSLKRN---RWTL--------TMEDLVPG-------DCGNYTCKVCNSLGCIRH--DTQVIVSD 193
            ...:.:|   .|.|        |.:.|:..       |.|:|.|...:.....||  ..|:|:.:
Mouse   597 LTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIILE 661

  Fly   194 RVNHKPILMTGPL-NLTLVVNSTGSMHCKYLSDLTSKKAWI-----FVPCHGMTNCSNNRSIIAE 252
            |:  .| ::||.| |.|..:..|..:.|....:.|....|.     .|...|:.....||:
Mouse   662 RM--AP-MITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRN---- 719

  Fly   253 DKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFG 317
                |....||.|..|.|||...|.||.:.:       .:|.::|     |:...|:...|.:.|
Mouse   720 ----LTIRRVRKEDGGLYTCQACNVLGCARA-------ETLFIIE-----GAQEKTNLEVIILVG 768

  Fly   318 GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQ 382
            ..:......|.:...:|.:|..                           :.|.:.|..:.:|
Mouse   769 TAVIAMFFWLLLVIVLRTVKRA---------------------------NEGELKTGYLSIV--- 803

  Fly   383 KQRTTVLQNGNEPAPFNEYEFPLD----------SNWELPRSHLVLGATLGEGAFGRVVMAE--- 434
                           .:..|.|||          |.||.||..|.||..||.||||:|:.|:
Mouse   804 ---------------MDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFG 853

  Fly   435 ----VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAP 494
                .....|||||:|||.|..:..:|:.|::::..||.|:|::||||.|:: .|||.||||:..
Mouse   854 IDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 918

  Fly   495 HGNLKDFL---------YKNRPFGRDQDRD-----------------SSQPPPSPPAHVITEKD- 532
            .|||..:|         ||::.....|.:|                 |||  .|..:..:.||.
Mouse   919 FGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQ--SSASSGFVEEKSL 981

  Fly   533 ---------------------LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
                                 ||.::.|:|:||::||||:||||||||||:|:|:..|:||.|||
Mouse   982 SDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFG 1046

  Fly   577 LARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSA 640
            ||||| :..||.||. :.|||:||||||::.::.|..:|||||:|:|||||.:.|..|||.:...
Mouse  1047 LARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID 1110

  Fly   641 EELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK-----EDYLD 700
            ||....|..|.||..|...:..:|..|..|||.:.:.||.|:|:||::..|||..     :||:.
Mouse  1111 EEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGNLLQANAQQDGKDYIV 1175

  Fly   701 VDIA-----------NLDTPPSTSDEEEDETD 721
            :.::           :|.|.|.:..|||:..|
Mouse  1176 LPMSETLSMEEDSGLSLPTSPVSCMEEEEVCD 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	25/118 (21%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	2/3 (67%)
		Ig strand E	157..161	CDD:409353	2/11 (18%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	2/4 (50%)
		Ig	200..289	CDD:472250	24/94 (26%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	3/4 (75%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	140/354 (40%)
Kdr	NP_034742.2	Ig	226..327	CDD:472250
		Ig strand B	244..248	CDD:409353
		Ig strand C	259..263	CDD:409353
		Ig strand E	292..296	CDD:409353
		Ig strand F	306..311	CDD:409353
		Ig strand G	319..322	CDD:409353
		Ig	331..419	CDD:472250
		Ig strand B	350..354	CDD:409353
		Ig strand C	363..367	CDD:409353
		Ig strand E	383..387	CDD:409353
		Ig strand F	397..402	CDD:409353
		Ig strand G	412..415	CDD:409353
		Ig_3	549..642	CDD:464046	21/96 (22%)
		I-set	665..742	CDD:400151	23/85 (27%)
		Ig strand B	682..686	CDD:409353	0/3 (0%)
		Ig strand C	695..699	CDD:409353	0/3 (0%)
		Ig strand E	718..722	CDD:409353	2/11 (18%)
		Ig strand F	732..737	CDD:409353	3/4 (75%)
		VEGFR-2_TMD	757..791	CDD:375470	6/60 (10%)
		PTKc_VEGFR2	824..1165	CDD:270681	139/343 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1272..1316