Protein Alignment htl and Hck

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_034537.2
• Gene: Hck / 15162
• MGIID: 96052
• Length: 524
• Species: Mus musculus
• Alignment Length: 473
• Identity: 144/473 - (30%)
• Similarity: 218/473 - (46%)
• Gaps: 82/473 - (17%)

  Fly   255 DQLDFVNVRMEQEG-WYTCVESNSLGQSNS----TAYLRVVRSLHVLEAGVASGSLHSTSFVYIF 314
            ||:    |.:|:.| |:   ::.||.....    :.|:..|.||.. |.....|.....:..::.
Mouse   101 DQM----VVLEEAGEWW---KARSLATKKEGYIPSNYVARVNSLET-EEWFFKGISRKDAERHLL 157

  Fly   315 VFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG----------DSSG 369
            ..|.::..||                 ::....|...::..|..|.|:.|.          ||.|
Mouse   158 APGNMLGSFM-----------------IRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGG 205

  Fly   370 -------SMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSN-WELPRSHLVLGATLGEGA 426
                   :..::...|:..:|.:..:.|..:.|....:.:.|.:.: ||:||..|.:...||.|.
Mouse   206 FYISPRSTFSSLQELVLHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQ 270

  Fly   427 FGRVVMAEVN-NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIV 490
            ||.|.||..| :..||||.:|.|..  .:.:.:.|..:||.: :|..::.|....||. |::::.
Mouse   271 FGEVWMATYNKHTKVAVKTMKPGSM--SVEAFLAEANLMKSL-QHDKLVKLHAVVSQE-PIFIVT 331

  Fly   491 EYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHR 555
            |:...|:|.|||        ..:..|.||.|.          ||.|:.||:.||.::..|..|||
Mouse   332 EFMAKGSLLDFL--------KSEEGSKQPLPK----------LIDFSAQISEGMAFIEQRNYIHR 378

  Fly   556 DLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            ||.|.|:|||...|.|||||||||.|:..:|..:. ..:.||||.|||::....:..||||||:|
Mouse   379 DLRAANILVSASLVCKIADFGLARIIEDNEYTARE-GAKFPIKWTAPEAINFGSFTIKSDVWSFG 442

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
            |||.||:|||:.|||. ||..|:...|..|.||.:|..|...:|.:|.:||....::||.|
Mouse   443 ILLMEIVTYGRIPYPG-MSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTF---- 502

  Fly   686 EYMDKLLQ-----TKEDY 698
            ||:..:|.     |:..|
Mouse   503 EYIQSVLDDFYTATESQY 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	9/38 (24%)
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353	2/3 (67%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/6 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	112/289 (39%)
Hck	NP_034537.2	SH3	80..135	CDD:473055	9/40 (23%)
		SH2_Src_HCK	138..241	CDD:198226	17/120 (14%)
		Protein Kinases, catalytic domain	252..522	CDD:473864	114/297 (38%)