DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Fyn

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_030100741.1 Gene:Fyn / 14360 MGIID:95602 Length:576 Species:Mus musculus


Alignment Length:586 Identity:153/586 - (26%)
Similarity:224/586 - (38%) Gaps:178/586 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 AWIFVPCHGMTNCSNNRSI-IAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLH 294
            |||.    |...|.:..:. :.|::|                    .||.||:...|.......|
Mouse    37 AWIM----GCVQCKDKEAAKLTEERD--------------------GSLNQSSGYRYGTDPTPQH 77

  Fly   295 VLEAGVAS----GSLHSTSFVYIFVFGGLIFIFMT-----------TLFVFYAIRKMKHEKVLKQ 344
            ....||.|    .:.|:.....:.||||:.....|           ||||.....:.:.|..|  
Mouse    78 YPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDL-- 140

  Fly   345 RIETVHQWTKKVIIFKPEGGGDSSGSMDT---------MIMPVVRIQKQ------------RTTV 388
               :.|:..|..|:...||....:.|:.|         .:.||..||.:            ...:
Mouse   141 ---SFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQL 202

  Fly   389 LQNGNEPAPF---------------------------NEYEF-PLDSN----------------- 408
            |..||....|                           ..|:. .||:.                 
Mouse   203 LSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLV 267

  Fly   409 -----------------------------------WELPRSHLVLGATLGEGAFGRVVMAEVN-N 437
                                               ||:||..|.|...||.|.||.|.|...| |
Mouse   268 QHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGN 332

  Fly   438 AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL 502
            ..||:|.:|.|....:  |.:.|.::||.: :|..::.|....|:. |:|::.||...|:|.|||
Mouse   333 TKVAIKTLKPGTMSPE--SFLEEAQIMKKL-KHDKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFL 393

  Fly   503 YKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDD 567
                   :|.:..:.:.|           :|:..|.|:|.||.|:.....|||||.:.|:||.:.
Mouse   394 -------KDGEGRALKLP-----------NLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNG 440

  Fly   568 YVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQ 632
            .:.|||||||||.|:..:|..:. ..:.||||.|||:.....:..||||||:||||.|::|.|:.
Mouse   441 LICKIADFGLARLIEDNEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRV 504

  Fly   633 PYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKED 697
            |||. |:..|:...:..|.||..|..|.::::.||..||..:.::||.|    ||:...|   ||
Mouse   505 PYPG-MNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTF----EYLQGFL---ED 561

  Fly   698 Y 698
            |
Mouse   562 Y 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 12/58 (21%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353 1/1 (100%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 0/4 (0%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 105/340 (31%)
FynXP_030100741.1 SH3_Fyn_Yrk 124..179 CDD:212939 13/59 (22%)
SH2_Src_Fyn_isoform_a_like 184..284 CDD:198281 8/99 (8%)
PTKc_Fyn 300..573 CDD:270655 107/294 (36%)
Blue background indicates that the domain is not in the aligned region.

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