DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and CSF1R

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001275634.1 Gene:CSF1R / 1436 HGNCID:2433 Length:972 Species:Homo sapiens


Alignment Length:692 Identity:201/692 - (29%)
Similarity:301/692 - (43%) Gaps:180/692 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 PEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLG--------CIRHDT 187
            |||.:.   |.|...|      .|:.:||::..|.|.:.|.|:....|..|        .:|:..
Human   347 PEPKLA---NATTKDT------YRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPP 402

  Fly   188 QVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSII-- 250
            :|.|                :...:|.:|::.|...........|:  .|.|.|:..:...::  
Human   403 EVSV----------------IWTFINGSGTLLCAASGYPQPNVTWL--QCSGHTDRCDEAQVLQV 449

  Fly   251 -----AEDKDQLDFVNV---------RMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVA 301
                 .|...|..|..|         .:|....|.|...||:| |.|.|::.:....|.      
Human   450 WDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVG-SGSWAFIPISAGAHT------ 507

  Fly   302 SGSLH-STSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG 365
                | ...|::..|....:.| |..|.:...:...|:::..|.::    :|  |:|       .
Human   508 ----HPPDEFLFTPVVVACMSI-MALLLLLLLLLLYKYKQKPKYQV----RW--KII-------E 554

  Fly   366 DSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRV 430
            ...|:..|.|.|.                ..|:||       .||.||::|..|.|||.||||:|
Human   555 SYEGNSYTFIDPT----------------QLPYNE-------KWEFPRNNLQFGKTLGAGAFGKV 596

  Fly   431 VMAEV-----NNAI--VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYV 488
            |.|..     .:|:  |||||:|.....|:..:|:.|:::|..:|:|.||:||||.|:..||:.|
Human   597 VEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLV 661

  Fly   489 IVEYAPHGNLKDFL-----------------------YKN------------------------- 505
            |.||..:|:|.:||                       |||                         
Human   662 ITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEM 726

  Fly   506 RPFG---------RDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARN 561
            ||..         :|.|::..:|        :..:||:.|:.|:|:||.:|||:.|||||:||||
Human   727 RPVSTSSNDSFSEQDLDKEDGRP--------LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARN 783

  Fly   562 VLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEI 626
            ||:::.:|.||.||||||||.:...|....|.|||:|||||||:.:..|..:|||||||||||||
Human   784 VLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 848

  Fly   627 MTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
            .:.|..|||.|:...:.|..:..|.:|.:||....|||.:|:.||......||.|.:|..::.: 
Human   849 FSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE- 912

  Fly   692 LQTKEDYLDVDIANLDTPP------STSDEEEDETDNLQKWC 727
             |.:||..:.|..||.:..      |:|.|.|:|:.:....|
Human   913 -QAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTC 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 17/67 (25%)
IG_like 113..191 CDD:214653 17/67 (25%)
IG_like 205..289 CDD:214653 20/99 (20%)
PKc_like 404..692 CDD:304357 132/351 (38%)
STYKc 416..688 CDD:214568 128/335 (38%)
CSF1RNP_001275634.1 IG_like 28..85 CDD:214653
ig 207..293 CDD:365836
Ig4_SCFR_like 299..400 CDD:319281 15/61 (25%)
Ig 416..495 CDD:319273 16/81 (20%)
Regulatory juxtamembrane domain 542..574 11/67 (16%)
PTKc_CSF-1R 543..914 CDD:133237 143/416 (34%)
Activation loop 796..818 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..950 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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