Protein Alignment htl and Frk

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_034367.2
• Gene: Frk / 14302
• MGIID: 103265
• Length: 512
• Species: Mus musculus
• Alignment Length: 485
• Identity: 148/485 - (30%)
• Similarity: 217/485 - (44%)
• Gaps: 115/485 - (23%)

  Fly   250 IAEDKDQLDFVNVRMEQEGWY------TCVESNSLGQSNST-AYLRVVR---------SLHVLEA 298
            :|||:.        ::.|.|:      ...|...|...|.| |:|  :|         ||.||:.
Mouse   112 VAEDRS--------LQAEPWFFGAIKRADAEKQLLYSENQTGAFL--IRESESQKGDFSLSVLDE 166

  Fly   299 GVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRK-------MKHEKVLKQRIETVHQWTKKV 356
            ||..                           .|.||:       :...||.....|.|:.:|.
Mouse   167 GVVK---------------------------HYRIRRLDEGGFFLTRRKVFSTLNEFVNYYTT-- 202

  Fly   357 IIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGAT 421
                     .|.|....:..|.::||           .|.|| :..:.....||:.|:.:.|...
Mouse   203 ---------TSDGLCVKLEKPCLKIQ-----------VPTPF-DLSYKTADQWEIDRNSIQLLKR 246

  Fly   422 LGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGP 485
            ||.|.||.|.....||.. ||||.:|.|..|.:  ..:||.::||.: ||..:|.|...|:...|
Mouse   247 LGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN--DFLREAQIMKSL-RHPKLIQLYAVCTLEDP 308

  Fly   486 LYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASR 550
            :|:|.|...||:|:::|         |:...|:      .|:|.:.|:   |.|:|.||.||.|:
Mouse   309 IYIITELMRHGSLQEYL---------QNDGGSK------IHLIQQVDM---AAQVASGMAYLESQ 355

  Fly   551 RCIHRDLAARNVLVSDDYVLKIADFGLAR--DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSK 613
            ..||||||||||||.:..:.|:|||||||  .:.:.|.|......:||:||.|||:::...:..|
Mouse   356 NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIK 420

  Fly   614 SDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDR 678
            |||||:||||:||:|||:.|| :.|:..::...|....|:.:|:.|....|.:|.:||:.....|
Mouse   421 SDVWSFGILLYEIITYGKMPY-SGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQR 484

  Fly   679 PPFTEIVEYMDKLLQTKEDYLDVDIANLDT 708
            |.|       :.|....|||.:.|.:..||
Mouse   485 PTF-------ETLHWKLEDYFETDCSYSDT 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	11/45 (24%)
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/10 (10%)
		Ig strand G	282..285	CDD:409353	2/3 (67%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	107/290 (37%)
Frk	NP_034367.2	SH3_Src_like	54..111	CDD:212779
		SH2_Src_Frk	119..214	CDD:199831	25/134 (19%)
		PTKc_Frk_like	232..501	CDD:270653	111/297 (37%)