DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Flt4

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_032055.1 Gene:Flt4 / 14257 MGIID:95561 Length:1363 Species:Mus musculus


Alignment Length:864 Identity:233/864 - (26%)
Similarity:353/864 - (40%) Gaps:250/864 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAAAWSWRASHSTITMTSGSLVVLFLLLSIWQP----AVQVEGRRQMANSQEMIKDHLGARSQ-- 59
            ::..|.||.                     |.|    |.:...|||..:.....:|.....:|  
Mouse   454 LSVQWHWRP---------------------WTPCKTFAQRSLRRRQQRDGMPQCRDWKEVTTQDA 497

  Fly    60 -----------------NKTPA--ITNNANQSSTSSADLDDGAADDDD----NKADLPVNVSSKP 101
                             |||.:  :..:||.|:.....:.:....|:.    ....:|...|   
Mouse   498 VNPIESLDSWTEFVEGKNKTVSKLVIQDANVSAMYKCVVVNKVGQDERLIYFYVTTIPDGFS--- 559

  Fly   102 YWRNPKKMSFLQTRPS-----GSLLTLNCHALGNPEPNITWYR--NGTVDWTRGYGSL------- 152
                      :::.||     |..:.|:|.|......::.|||  ..|:...:|...|       
Mouse   560 ----------IESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVH 614

  Fly   153 -----------------KRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPI 200
                             :....:|.:..:.|.|.|:|.|:|.:.....:|..:..:|.:....|.
Mouse   615 LFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPR 679

  Fly   201 LMTGPLNLT-LVVNSTGS--MHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSI-------IAEDKD 255
            |..   ||| |:||.:.|  |.|...........|.          .:.|.:       :|:...
Mouse   680 LTQ---NLTDLLVNVSDSLEMRCPVAGAHVPSIVWY----------KDERLLEKESGIDLADSNQ 731

  Fly   256 QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLI 320
            :|....||.|..|.|.|...|:.|..||:|.:.|       |.....||:.    :.|.:..|:|
Mouse   732 RLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAV-------EGSEDKGSME----IVILIGTGVI 785

  Fly   321 --FIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQK 383
              |.::..|.:|..:::..|..:....:..:                     ||...:|:     
Mouse   786 AVFFWVLLLLIFCNMKRPAHADIKTGYLSII---------------------MDPGEVPL----- 824

  Fly   384 QRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE---VNNA----IVA 441
                     .|...:..|:   .|.||.||..|.||..||.||||:||.|.   :|..    .||
Mouse   825 ---------EEQCEYLSYD---ASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVA 877

  Fly   442 VKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAPHGNLKDFLYKN 505
            |||:|||.|..:..:|:.|::::..||.|:|::||||.|:: ||||.||||:..:|||.:||...
Mouse   878 VKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVK 942

  Fly   506 R----PFGR---DQDR-----------DSSQPPPSPPA--------------------------H 526
            |    |:..   :|.|           |..:|..|..|                          .
Mouse   943 RDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLS 1007

  Fly   527 VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDI-QSTDYYRKN 590
            .:|.:||:.::.|:||||::||||:||||||||||:|:|:..::||.|||||||| :..||.||.
Mouse  1008 PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKG 1072

  Fly   591 TNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEK 655
             :.|||:|||||||:.:|.|.::|||||:|:|||||.:.|..|||.:...||....|..|.||..
Mouse  1073 -SARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRA 1136

  Fly   656 PAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ-------------------TKED-YLD 700
            |...:..|..:|:.||..:...||.|:::||.:..|||                   ::|| ::.
Mouse  1137 PELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHSSQSSEEDGFMQ 1201

  Fly   701 VDIANL--------DTPPS 711
            .....|        |:|||
Mouse  1202 ASTTALHITEADADDSPPS 1220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 20/120 (17%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 25/98 (26%)
Ig strand B 216..220 CDD:409353 2/5 (40%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 2/2 (100%)
Protein Kinases, catalytic domain 404..692 CDD:473864 140/340 (41%)
Flt4NP_032055.1 IgI_VEGFR 230..329 CDD:409448
Ig strand A 230..234 CDD:409448
Ig strand A' 240..244 CDD:409448
Ig strand B 246..255 CDD:409448
Ig strand C 262..267 CDD:409448
Ig strand C' 270..272 CDD:409448
Ig strand D 276..284 CDD:409448
Ig strand E 289..297 CDD:409448
Ig strand F 307..313 CDD:409448
Ig strand G 318..324 CDD:409448
Ig 331..418 CDD:472250
Ig strand B 352..356 CDD:409449
Ig strand C 365..369 CDD:409449
Ig strand E 382..386 CDD:409449
Ig strand F 396..401 CDD:409449
Ig strand G 411..414 CDD:409449
IG_like 570..663 CDD:214653 17/92 (18%)
Ig strand B 574..578 CDD:409353 1/3 (33%)
Ig strand C 587..591 CDD:409353 0/3 (0%)
Ig strand E 636..640 CDD:409353 1/3 (33%)
Ig strand F 650..655 CDD:409353 2/4 (50%)
Ig 678..765 CDD:472250 26/99 (26%)
Ig strand B 695..699 CDD:409353 1/3 (33%)
Ig strand C 708..712 CDD:409353 0/3 (0%)
Ig strand E 731..735 CDD:409353 1/3 (33%)
Ig strand F 745..750 CDD:409353 2/4 (50%)
VEGFR-2_TMD 770..804 CDD:375470 8/37 (22%)
Protein Kinases, catalytic domain 837..1175 CDD:473864 141/338 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Blue background indicates that the domain is not in the aligned region.

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