DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Flt3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_034359.2	Gene:	Flt3 / 14255	MGIID:	95559	Length:	1000	Species:	Mus musculus

Alignment Length:	867	Identity:	234/867 - (26%)
Similarity:	327/867 - (37%)	Gaps:	300/867 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWY--------------- 138
            |..|..:.|..:||:|..:...           .|.|.:.|.|||.:.|.
Mouse   160 NVRDTQLYVLRRPYFRKMENQD-----------ALLCISEGVPEPTVEWVLCSSHRESCKEEGPA 213

  Fly   139 ---------------------RNG---------TVD--------------------WTR------ 147
                                 ||.         |:|                    |.|
Mouse   214 VVRKEEKVLHELFGTDIRCCARNALGRECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHV 278

  Fly   148 --GYGSLKRNRWTLTMEDLVPG----------------------------DCGNYTCKVCNSLGC 182
              |:|.    .|.|..:.|..|                            |.|.|||      ..
Mouse   279 NHGFGL----TWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTC------SS 333

  Fly   183 IRHDTQ-VIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSK-------KA-------W 232
            .:|.:| .:|:       ||..|      .:|:|.|.. :|..|...|       ||       |
Mouse   334 SKHPSQSALVT-------ILEKG------FINATSSQE-EYEIDPYEKFCFSVRFKAYPRIRCTW 384

  Fly   233 IF----VPC--HGMTN-------CSNNRS----IIAEDKDQLDF-----VNVRMEQE-------- 267
            ||    .||  .|:.:       |.:...    |...:.|...|     :|:|.:.:
Mouse   385 IFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASAS 449

  Fly   268 ------------GWY---------TCVESNSLGQSNSTAYLRVV------RSLHVLEAG------ 299
                        .|.         .|.|....|..|..|..:|.      .:|::.|||
Mouse   450 QASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVK 514

  Fly   300 -VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363
             .|..|: .||...||:.....|.|:.....|||...:....::...:...|::.|:   |:.|
Mouse   515 CCAYNSM-GTSCETIFLNSPGPFPFIQDNISFYATIGLCLPFIVVLIVLICHKYKKQ---FRYE- 574

  Fly   364 GGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFG 428
                  |...||        |.|..|.|......|.:||:  |..||.||.:|..|..||.||||
Mouse   575 ------SQLQMI--------QVTGPLDNEYFYVDFRDYEY--DLKWEFPRENLEFGKVLGSGAFG 623

  Fly   429 RVVMAEVN-------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPL 486
            ||:.|...       :..|||||:||.....:..:|:.|:::|..:|.|.||:||||.|:.:||:
Mouse   624 RVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPV 688

  Fly   487 YVIVEYAPHGNLKDFL-YKNRPFGRD----------------QDRDSSQPPPS------PP---- 524
            |:|.||..:|:|.::| .|...|.|.                |...:|..|.|      ||
Mouse   689 YLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQL 753

  Fly   525 -----------------------------AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAAR 560
                                         .:|:|.:||:.||:|:|:||::|..:.|:|||||||
Mouse   754 SGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAAR 818

  Fly   561 NVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625
            ||||:...|:||.||||||||.|...|....|.|||:||||||||.|..|..|||||||||||||
Mouse   819 NVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE 883

  Fly   626 IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690
            |.:.|..|||.|......|..:.||.:||:|...:..||.:|:.||.|::..||.|..:..::..
Mouse   884 IFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGC 948

  Fly   691 LLQTKEDYLDVDI-ANLDTPPS 711
            .|...|:.:..:: .|:...||
Mouse   949 QLAEAEEAMYQNMGGNVPEHPS 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	26/180 (14%)
		IG_like	113..191	CDD:214653	26/179 (15%)
		IG_like	205..289	CDD:214653	26/148 (18%)
		PKc_like	404..692	CDD:304357	137/350 (39%)
		STYKc	416..688	CDD:214568	132/334 (40%)
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..67
		ig	256..346	CDD:278476	16/106 (15%)
		PKc_like	573..950	CDD:304357	148/393 (38%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598		1/5 (20%)
		Pkinase_Tyr	611..946	CDD:285015	132/334 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1000		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810