DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Flt3

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_034359.2 Gene:Flt3 / 14255 MGIID:95559 Length:1000 Species:Mus musculus


Alignment Length:867 Identity:234/867 - (26%)
Similarity:327/867 - (37%) Gaps:300/867 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 NKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWY--------------- 138
            |..|..:.|..:||:|..:...           .|.|.:.|.|||.:.|.               
Mouse   160 NVRDTQLYVLRRPYFRKMENQD-----------ALLCISEGVPEPTVEWVLCSSHRESCKEEGPA 213

  Fly   139 ---------------------RNG---------TVD--------------------WTR------ 147
                                 ||.         |:|                    |.|      
Mouse   214 VVRKEEKVLHELFGTDIRCCARNALGRECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHV 278

  Fly   148 --GYGSLKRNRWTLTMEDLVPG----------------------------DCGNYTCKVCNSLGC 182
              |:|.    .|.|..:.|..|                            |.|.|||      ..
Mouse   279 NHGFGL----TWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTC------SS 333

  Fly   183 IRHDTQ-VIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSK-------KA-------W 232
            .:|.:| .:|:       ||..|      .:|:|.|.. :|..|...|       ||       |
Mouse   334 SKHPSQSALVT-------ILEKG------FINATSSQE-EYEIDPYEKFCFSVRFKAYPRIRCTW 384

  Fly   233 IF----VPC--HGMTN-------CSNNRS----IIAEDKDQLDF-----VNVRMEQE-------- 267
            ||    .||  .|:.:       |.:...    |...:.|...|     :|:|.:.:        
Mouse   385 IFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASAS 449

  Fly   268 ------------GWY---------TCVESNSLGQSNSTAYLRVV------RSLHVLEAG------ 299
                        .|.         .|.|....|..|..|..:|.      .:|::.|||      
Mouse   450 QASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVK 514

  Fly   300 -VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG 363
             .|..|: .||...||:.....|.|:.....|||...:....::...:...|::.|:   |:.| 
Mouse   515 CCAYNSM-GTSCETIFLNSPGPFPFIQDNISFYATIGLCLPFIVVLIVLICHKYKKQ---FRYE- 574

  Fly   364 GGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFG 428
                  |...||        |.|..|.|......|.:||:  |..||.||.:|..|..||.||||
Mouse   575 ------SQLQMI--------QVTGPLDNEYFYVDFRDYEY--DLKWEFPRENLEFGKVLGSGAFG 623

  Fly   429 RVVMAEVN-------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPL 486
            ||:.|...       :..|||||:||.....:..:|:.|:::|..:|.|.||:||||.|:.:||:
Mouse   624 RVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPV 688

  Fly   487 YVIVEYAPHGNLKDFL-YKNRPFGRD----------------QDRDSSQPPPS------PP---- 524
            |:|.||..:|:|.::| .|...|.|.                |...:|..|.|      ||    
Mouse   689 YLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQL 753

  Fly   525 -----------------------------AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAAR 560
                                         .:|:|.:||:.||:|:|:||::|..:.|:|||||||
Mouse   754 SGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAAR 818

  Fly   561 NVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625
            ||||:...|:||.||||||||.|...|....|.|||:||||||||.|..|..|||||||||||||
Mouse   819 NVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE 883

  Fly   626 IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690
            |.:.|..|||.|......|..:.||.:||:|...:..||.:|:.||.|::..||.|..:..::..
Mouse   884 IFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGC 948

  Fly   691 LLQTKEDYLDVDI-ANLDTPPS 711
            .|...|:.:..:: .|:...||
Mouse   949 QLAEAEEAMYQNMGGNVPEHPS 970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 29/191 (15%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 3/4 (75%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 29/153 (19%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 3/17 (18%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/13 (15%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 137/350 (39%)
Flt3NP_034359.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..67
ig 256..346 CDD:395002 16/106 (15%)
Ig strand B 269..273 CDD:409353 1/3 (33%)
Ig strand C 283..287 CDD:409353 1/7 (14%)
Ig strand E 315..318 CDD:409353 0/2 (0%)
Ig strand F 328..333 CDD:409353 3/10 (30%)
7tm_GPCRs <491..>586 CDD:475119 25/113 (22%)
Protein Kinases, catalytic domain 573..950 CDD:473864 148/393 (38%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250 592..598 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1000 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

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