DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Fgfr4

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_006517162.3 Gene:Fgfr4 / 14186 MGIID:95525 Length:829 Species:Mus musculus


Alignment Length:684 Identity:277/684 - (40%)
Similarity:371/684 - (54%) Gaps:78/684 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LDD---GAADDDDNKADLPVNVSSK----------PYWRNPKKM-SFLQTRPSGSLLTLNCHALG 129
            :||   ..::|:|     |..:||.          |||.:|::| ..|...|:|:.:...|.|.|
Mouse   144 MDDSLTSISNDED-----PKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAG 203

  Fly   130 NPEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIV 191
            ||.|.|.|.::|..   :...|...|:...|:|.||.:||.|.|.|||.|.||||.||:...:.|
Mouse   204 NPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDV 268

  Fly   192 SDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN---------- 245
            .:|..|:|||..| |.|.|.||.|...:.||..||......|:   .|.:.|.|:          
Mouse   269 LERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL---KHVVINGSSFGADGFPYVQ 330

  Fly   246 ---NRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHS 307
               ...|.:.:.:.|...||..|..|.|||:..||:|.|..:|:|.|:.. ..|....|:.....
Mouse   331 VLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPE-EDLTWTTATPEARY 394

  Fly   308 TSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLK----QRIETVHQWTKKVIIFKPEGGGDSS 368
            |..: ::|.|.|:.:.:..|...|      |.:|::    ::..|:.:.::..:..:......||
Mouse   395 TDII-LYVSGSLVLLVLLLLAGVY------HRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSS 452

  Fly   369 GSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMA 433
            |.....::..||:......:|..      ....:.|||..||.||..||||..||||.||:||.|
Mouse   453 GKSSLSLVRGVRLSSSGPPLLTG------LVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRA 511

  Fly   434 EV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVI 489
            |.         ..:.|||||:|:..:|.|:|.||.||||||:||||.|||||||.|:|.||||||
Mouse   512 EAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 576

  Fly   490 VEYAPHGNLKDFLYKNRPFGRDQDRD---SSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRR 551
            ||.|..|||::||...||.|.|...|   ||:.|.|.||       |:..|:|:||||.||.||:
Mouse   577 VECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPA-------LVSCAYQVARGMQYLESRK 634

  Fly   552 CIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDV 616
            |||||||||||||::|.|:|||||||||.:...|||:|.:|||||:||||||:|.::.|..:|||
Mouse   635 CIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 699

  Fly   617 WSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPF 681
            ||:|||||||.|.|..|||.| ..|||::.|..|.|||:|..|...:|.|||:|||.....||.|
Mouse   700 WSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTF 763

  Fly   682 TEIVEYMDK-LLQTKEDYLDVDIANLDTPPSTSD 714
            .::||.:|| ||...|:|||:.:......||..|
Mouse   764 KQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGD 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 37/93 (40%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 3/4 (75%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 32/102 (31%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 170/300 (57%)
Fgfr4XP_006517162.3 IG_like 70..143 CDD:214653
Ig strand B 80..84 CDD:409353
Ig strand E 111..115 CDD:409353
Ig strand F 125..130 CDD:409353
Ig 174..268 CDD:472250 37/93 (40%)
Ig strand B 195..199 CDD:409353 0/3 (0%)
Ig strand C 208..212 CDD:409353 1/3 (33%)
Ig strand E 234..238 CDD:409353 2/3 (67%)
Ig strand F 248..253 CDD:409353 3/4 (75%)
Ig strand G 261..264 CDD:409353 1/2 (50%)
Ig 276..378 CDD:472250 33/104 (32%)
Ig strand B 294..298 CDD:409353 0/3 (0%)
Ig strand C 307..311 CDD:409353 0/3 (0%)
Ig strand E 343..347 CDD:409353 1/3 (33%)
Ig strand F 357..362 CDD:409353 3/4 (75%)
Ig strand G 370..373 CDD:409353 0/2 (0%)
PTKc_FGFR4 481..794 CDD:133230 176/320 (55%)
Blue background indicates that the domain is not in the aligned region.

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