DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and Fgfr4

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_006517162.3	Gene:	Fgfr4 / 14186	MGIID:	95525	Length:	829	Species:	Mus musculus

Alignment Length:	684	Identity:	277/684 - (40%)
Similarity:	371/684 - (54%)	Gaps:	78/684 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LDD---GAADDDDNKADLPVNVSSK----------PYWRNPKKM-SFLQTRPSGSLLTLNCHALG 129
            :||   ..::|:|     |..:||.          |||.:|::| ..|...|:|:.:...|.|.|
Mouse   144 MDDSLTSISNDED-----PKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAG 203

  Fly   130 NPEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIV 191
            ||.|.|.|.::|..   :...|...|:...|:|.||.:||.|.|.|||.|.||||.||:...:.|
Mouse   204 NPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDV 268

  Fly   192 SDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN---------- 245
            .:|..|:|||..| |.|.|.||.|...:.||..||......|:   .|.:.|.|:
Mouse   269 LERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL---KHVVINGSSFGADGFPYVQ 330

  Fly   246 ---NRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHS 307
               ...|.:.:.:.|...||..|..|.|||:..||:|.|..:|:|.|:.. ..|....|:.....
Mouse   331 VLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPE-EDLTWTTATPEARY 394

  Fly   308 TSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLK----QRIETVHQWTKKVIIFKPEGGGDSS 368
            |..: ::|.|.|:.:.:..|...|      |.:|::    ::..|:.:.::..:..:......||
Mouse   395 TDII-LYVSGSLVLLVLLLLAGVY------HRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSS 452

  Fly   369 GSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMA 433
            |.....::..||:......:|..      ....:.|||..||.||..||||..||||.||:||.|
Mouse   453 GKSSLSLVRGVRLSSSGPPLLTG------LVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRA 511

  Fly   434 EV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVI 489
            |.         ..:.|||||:|:..:|.|:|.||.||||||:||||.|||||||.|:|.||||||
Mouse   512 EAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 576

  Fly   490 VEYAPHGNLKDFLYKNRPFGRDQDRD---SSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRR 551
            ||.|..|||::||...||.|.|...|   ||:.|.|.||       |:..|:|:||||.||.||:
Mouse   577 VECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPA-------LVSCAYQVARGMQYLESRK 634

  Fly   552 CIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDV 616
            |||||||||||||::|.|:|||||||||.:...|||:|.:|||||:||||||:|.::.|..:|||
Mouse   635 CIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 699

  Fly   617 WSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPF 681
            ||:|||||||.|.|..|||.| ..|||::.|..|.|||:|..|...:|.|||:|||.....||.|
Mouse   700 WSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTF 763

  Fly   682 TEIVEYMDK-LLQTKEDYLDVDIANLDTPPSTSD 714
            .::||.:|| ||...|:|||:.:......||..|
Mouse   764 KQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGD 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	32/81 (40%)
		IG_like	113..191	CDD:214653	31/80 (39%)
		IG_like	205..289	CDD:214653	29/96 (30%)
		PKc_like	404..692	CDD:304357	170/300 (57%)
		STYKc	416..688	CDD:214568	161/283 (57%)
Fgfr4	XP_006517162.3	IGc2	77..134	CDD:197706
		Ig	184..268	CDD:386229	32/83 (39%)
		Ig3_FGFR-2	291..378	CDD:143266	24/89 (27%)
		PTKc_FGFR4	481..794	CDD:133230	176/320 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1221
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8830
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770