DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Fgfr3

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001156689.1 Gene:Fgfr3 / 14184 MGIID:95524 Length:802 Species:Mus musculus


Alignment Length:688 Identity:283/688 - (41%)
Similarity:388/688 - (56%) Gaps:78/688 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 SSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWY 138
            ||.|.:||....:|..|         |||..|::| ..|...|:.:.:...|.|.|||.|:|:|.
Mouse   128 SSGDDEDGEDVAEDTGA---------PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL 183

  Fly   139 RNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPI 200
            :||..   :...|...|:..:|:|.||.:||.|.|||||.|.|..|.||....:.|.:|..|:||
Mouse   184 KNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPI 248

  Fly   201 LMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN-----------NRSIIAED 253
            |..| |.|.|.::.|....|||..||......|:   .|...|.|.           .:|.|:|:
Mouse   249 LQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWL---KHVEVNGSKVGPDGTPYVTVLKSWISEN 310

  Fly   254 KD---QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRV----VRSLHVLEAGVASGSLHSTSFV 311
            .:   :|...||.....|.|.|..:|.:|.:....:|||    .....::|...| ||:::....
Mouse   311 VEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEEELMETDEA-GSVYAGVLS 374

  Fly   312 YIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIF--KPEGGGDSSGSMDTM 374
            |..||  .:||.:....:...:|. ..:|.|..  .|||    ||..|  |.:...:|:.||::.
Mouse   375 YGVVF--FLFILVVAAVILCRLRS-PPKKGLGS--PTVH----KVSRFPLKRQVSLESNSSMNSN 430

  Fly   375 IMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE--- 434
             .|:|||.:     |.:|..|  |..:|.|.|.|..|||.|:.|.||..||||.||:|||||   
Mouse   431 -TPLVRIAR-----LSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIG 489

  Fly   435 ------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYA 493
                  .....|||||:|:..||.|::.||.|||:||:||:|.|||||||.|:|.|||||:||||
Mouse   490 IDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYA 554

  Fly   494 PHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLA 558
            ..|||::||...||.|.|...|:.:.|...    :|.|||:..|:|:||||:||||::|||||||
Mouse   555 AKGNLREFLRARRPPGMDYSFDACRLPEEQ----LTCKDLVSCAYQVARGMEYLASQKCIHRDLA 615

  Fly   559 ARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILL 623
            ||||||::|.|:||||||||||:.:.|||:|.||||||:||||||:|.::.|..:|||||:|:||
Mouse   616 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 680

  Fly   624 WEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM 688
            |||.|.|..|||.| ..|||:..|..|.||:|||.|:.::|::||:|||.....||.|.::||.:
Mouse   681 WEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDL 744

  Fly   689 DKLL--QTKEDYLDVDI-------ANLDTPPSTSDEEE 717
            |::|  .:.::|||:.:       ...|||.|:|..::
Mouse   745 DRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDD 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 31/81 (38%)
IG_like 113..191 CDD:214653 30/80 (38%)
IG_like 205..289 CDD:214653 25/97 (26%)
PKc_like 404..692 CDD:304357 165/296 (56%)
STYKc 416..688 CDD:214568 158/280 (56%)
Fgfr3NP_001156689.1 IGc2 51..110 CDD:197706
IG 52..108 CDD:214652
Ig2_FGFR 155..239 CDD:143265 31/83 (37%)
IG_like 254..349 CDD:214653 25/97 (26%)
Ig3_FGFR 262..350 CDD:143175 23/90 (26%)
PTKc_FGFR3 455..788 CDD:173652 174/333 (52%)
Pkinase_Tyr 468..744 CDD:285015 158/280 (56%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 321 1.000 Domainoid score I1221
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55437
Inparanoid 1 1.050 477 1.000 Inparanoid score I1461
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50158
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000923
OrthoInspector 1 1.000 - - mtm8830
orthoMCL 1 0.900 - - OOG6_100013
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6544
SonicParanoid 1 1.000 - - X537
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.900

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