DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Fgfr2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_034337.2 Gene:Fgfr2 / 14183 MGIID:95523 Length:840 Species:Mus musculus


Alignment Length:810 Identity:296/810 - (36%)
Similarity:412/810 - (50%) Gaps:138/810 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SWRASH----STITMTS-GSLVVLFLL----------------------------LSIWQPAVQV 37
            :||...    .|:||.| |..:.|.|:                            ..|.||...|
Mouse     6 TWRYGRGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEAYV 70

  Fly    38 EGRRQMANSQEMIKD-----------HLGARS-----------QNKTPAITN------------- 67
            ....:....|.|:||           |||..:           :..||..:.             
Mouse    71 VAPGESLELQCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTAARTVDSE 135

  Fly    68 ------NANQSSTSSADLDDGAADDD---DNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLT 122
                  |...:.:|..|.||..:.:|   :|:::     ...|||.|.:|| ..|...|:.:.:.
Mouse   136 TWYFMVNVTDAISSGDDEDDTDSSEDVVSENRSN-----QRAPYWTNTEKMEKRLHAVPAANTVK 195

  Fly   123 LNCHALGNPEPNITWYRNGTVDWTR-----GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGC 182
            ..|.|.|||.|.:.|.:||. ::.:     || .::...|:|.||.:||.|.|||||.|.|..|.
Mouse   196 FRCPAGGNPTPTMRWLKNGK-EFKQEHRIGGY-KVRNQHWSLIMESVVPSDKGNYTCLVENEYGS 258

  Fly   183 IRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCS-- 244
            |.|...:.|.:|..|:|||..| |.|.:.||.......||..||......||   .|...|.|  
Mouse   259 INHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI---KHVEKNGSKY 320

  Fly   245 -----------NNRSIIAEDK--DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVL 296
                       ....:...||  :.|...||..|..|.|||:..||:|.|..:|:|.|:.: .|.
Mouse   321 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA-PVR 384

  Fly   297 EAGVASGSLHSTSFVYIFVFG-GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFK 360
            |..:.:    |..::.|.::. |:..|....:.|.:...|...:|........||:.||::.:.:
Mouse   385 EKEITA----SPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRR 445

  Fly   361 P-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATL 422
            . ....:||.||::. .|:|||   .|.:....:.|  |..:|||.|.|..||.||..|.||..|
Mouse   446 QVTVSAESSSSMNSN-TPLVRI---TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 506

  Fly   423 GEGAFGRVVMAEV--------NNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478
            |||.||:|||||.        ..|: |||||:|:..|:.|::.||.|||:||:||:|.|||||||
Mouse   507 GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLG 571

  Fly   479 CCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARG 543
            .|:|:||||||||||..|||:::|...||.|.:...|.::.|...    :|.|||:...:|:|||
Mouse   572 ACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ----MTFKDLVSCTYQLARG 632

  Fly   544 MDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEK 608
            |:||||::|||||||||||||:::.|:|||||||||||.:.|||:|.||||||:||||||:|.::
Mouse   633 MEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 697

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|..:|||||:|:|:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||.
Mouse   698 VYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHA 761

  Fly   674 NADDRPPFTEIVEYMDKL--LQTKEDYLDV 701
            ....||.|.::||.:|::  |.|.|:|||:
Mouse   762 VPSQRPTFKQLVEDLDRILTLTTNEEYLDL 791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 36/95 (38%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 32/104 (31%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 161/298 (54%)
Fgfr2NP_034337.2 Ig 50..143 CDD:472250 13/92 (14%)
Ig strand B 77..81 CDD:409353 0/3 (0%)
Ig strand C 88..92 CDD:409353 0/3 (0%)
Ig strand E 109..113 CDD:409353 0/3 (0%)
Ig strand F 123..128 CDD:409353 0/4 (0%)
Ig strand G 136..139 CDD:409353 0/2 (0%)
IgI_2_FGFR 173..267 CDD:409443 36/95 (38%)
Ig strand A 173..176 CDD:409443 2/2 (100%)
Ig strand A' 184..189 CDD:409443 1/4 (25%)
Ig strand B 193..201 CDD:409443 1/7 (14%)
Ig strand C 207..212 CDD:409443 1/4 (25%)
Ig strand C' 215..217 CDD:409443 0/2 (0%)
Ig strand D 226..229 CDD:409443 1/3 (33%)
Ig strand E 233..238 CDD:409443 2/4 (50%)
Ig strand F 247..254 CDD:409443 5/6 (83%)
Ig strand G 257..267 CDD:409443 3/9 (33%)
IgI_3_FGFR2 275..379 CDD:409444 33/106 (31%)
Ig strand A 275..278 CDD:409444 2/2 (100%)
Ig strand A' 282..286 CDD:409444 2/3 (67%)
Ig strand B 294..301 CDD:409444 2/6 (33%)
Ig strand C 305..312 CDD:409444 2/9 (22%)
Ig strand D 327..332 CDD:409444 0/4 (0%)
Ig strand E 344..349 CDD:409444 1/4 (25%)
Ig strand F 357..365 CDD:409444 4/7 (57%)
Ig strand G 368..376 CDD:409444 3/7 (43%)
PTKc_FGFR2 475..787 CDD:270679 168/316 (53%)

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