DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Fgfr2

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_034337.2	Gene:	Fgfr2 / 14183	MGIID:	95523	Length:	840	Species:	Mus musculus

Alignment Length:	810	Identity:	296/810 - (36%)
Similarity:	412/810 - (50%)	Gaps:	138/810 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SWRASH----STITMTS-GSLVVLFLL----------------------------LSIWQPAVQV 37
            :||...    .|:||.| |..:.|.|:                            ..|.||...|
Mouse     6 TWRYGRGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEAYV 70

  Fly    38 EGRRQMANSQEMIKD-----------HLGARS-----------QNKTPAITN------------- 67
            ....:....|.|:||           |||..:           :..||..:.
Mouse    71 VAPGESLELQCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTAARTVDSE 135

  Fly    68 ------NANQSSTSSADLDDGAADDD---DNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLT 122
                  |...:.:|..|.||..:.:|   :|:::     ...|||.|.:|| ..|...|:.:.:.
Mouse   136 TWYFMVNVTDAISSGDDEDDTDSSEDVVSENRSN-----QRAPYWTNTEKMEKRLHAVPAANTVK 195

  Fly   123 LNCHALGNPEPNITWYRNGTVDWTR-----GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGC 182
            ..|.|.|||.|.:.|.:||. ::.:     || .::...|:|.||.:||.|.|||||.|.|..|.
Mouse   196 FRCPAGGNPTPTMRWLKNGK-EFKQEHRIGGY-KVRNQHWSLIMESVVPSDKGNYTCLVENEYGS 258

  Fly   183 IRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCS-- 244
            |.|...:.|.:|..|:|||..| |.|.:.||.......||..||......||   .|...|.|
Mouse   259 INHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI---KHVEKNGSKY 320

  Fly   245 -----------NNRSIIAEDK--DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVL 296
                       ....:...||  :.|...||..|..|.|||:..||:|.|..:|:|.|:.: .|.
Mouse   321 GPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA-PVR 384

  Fly   297 EAGVASGSLHSTSFVYIFVFG-GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFK 360
            |..:.:    |..::.|.::. |:..|....:.|.:...|...:|........||:.||::.:.:
Mouse   385 EKEITA----SPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRR 445

  Fly   361 P-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATL 422
            . ....:||.||::. .|:|||   .|.:....:.|  |..:|||.|.|..||.||..|.||..|
Mouse   446 QVTVSAESSSSMNSN-TPLVRI---TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 506

  Fly   423 GEGAFGRVVMAEV--------NNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478
            |||.||:|||||.        ..|: |||||:|:..|:.|::.||.|||:||:||:|.|||||||
Mouse   507 GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLG 571

  Fly   479 CCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARG 543
            .|:|:||||||||||..|||:::|...||.|.:...|.::.|...    :|.|||:...:|:|||
Mouse   572 ACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ----MTFKDLVSCTYQLARG 632

  Fly   544 MDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEK 608
            |:||||::|||||||||||||:::.|:|||||||||||.:.|||:|.||||||:||||||:|.::
Mouse   633 MEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 697

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|..:|||||:|:|:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||.
Mouse   698 VYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHA 761

  Fly   674 NADDRPPFTEIVEYMDKL--LQTKEDYLDV 701
            ....||.|.::||.:|::  |.|.|:|||:
Mouse   762 VPSQRPTFKQLVEDLDRILTLTTNEEYLDL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	30/83 (36%)
		IG_like	113..191	CDD:214653	29/82 (35%)
		IG_like	205..289	CDD:214653	29/98 (30%)
		PKc_like	404..692	CDD:304357	161/298 (54%)
		STYKc	416..688	CDD:214568	154/280 (55%)
Fgfr2	NP_034337.2	Ig	66..143	CDD:325142	11/76 (14%)
		Ig2_FGFR	183..267	CDD:143265	30/85 (35%)
		Ig3_FGFR-2	290..379	CDD:143266	25/91 (27%)
		PTKc_FGFR2	475..787	CDD:270679	168/316 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1221
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8830
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770