DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Fgfr1

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_034336.2 Gene:Fgfr1 / 14182 MGIID:95522 Length:822 Species:Mus musculus


Alignment Length:790 Identity:298/790 - (37%)
Similarity:424/790 - (53%) Gaps:100/790 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AAAWSWRASHSTITMTSGSLVVLFLLL-----SI-W-QPAVQ-VEGRRQMANSQEM-IKDHLGAR 57
            |..|.......::.:..|.|:.|...|     || | :..|| ||..|.....:|: ::|.:.|.
Mouse    31 AQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPAD 95

  Fly    58 SQNKTPAITNNANQSSTS-----------SADLDDGAADDDDNKADLPVNVSSK-------PYWR 104
            | .....:|::.:.|.|:           |::.||   ||||:.::.....::|       |||.
Mouse    96 S-GLYACVTSSPSGSDTTYFSVNVSDALPSSEDDD---DDDDSSSEEKETDNTKPNRRPVAPYWT 156

  Fly   105 NPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWYRNG---TVDWTRGYGSLKRNRWTLTMEDLV 165
            :|:|| ..|...|:...:...|.:.|.|.|.:.|.:||   ..|...|...::...|::.|:.:|
Mouse   157 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV 221

  Fly   166 PGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSK 229
            |.|.|||||.|.|..|.|.|..|:.|.:|..|:|||..| |.|.|:.:.|.....||..||....
Mouse   222 PSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPH 286

  Fly   230 KAWI-FVPCHGMTNCSNN---------RSIIAEDKDQ--LDFVNVRMEQEGWYTCVESNSLGQSN 282
            ..|: .:..:|.....:|         ..:...||:.  |...||..|..|.|||:..||:|.|:
Mouse   287 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSH 351

  Fly   283 STAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMK--------HE 339
            .:|:|.|:.:|....| |.:..|:..  :.|:..|..:...|....:.|   |||        |.
Mouse   352 HSAWLTVLEALEERPA-VMTSPLYLE--IIIYCTGAFLISCMLGSVIIY---KMKSGTKKSDFHS 410

  Fly   340 KVLKQRIETVHQWTKKVIIFKP-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEY 401
            ::      .||:..|.:.:.:. ....|||.||::.::.|      |.:.|.:...|  |..:||
Mouse   411 QM------AVHKLAKSIPLRRQVTVSADSSASMNSGVLLV------RPSRLSSSGTPMLAGVSEY 463

  Fly   402 EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV-------NNAI--VAVKMVKEGHTDDDIASL 457
            |.|.|..|||||..||||..||||.||:||:||.       .|.:  |||||:|...|:.|::.|
Mouse   464 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 528

  Fly   458 VREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPS 522
            :.|||:||:||:|.|||||||.|:|:||||||||||..|||:::|...||.|.:.    ...|..
Mouse   529 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY----CYNPSH 589

  Fly   523 PPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
            .|...::.|||:..|:|:||||:||||::|||||||||||||::|.|:|||||||||||...|||
Mouse   590 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 654

  Fly   588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQR 652
            :|.||||||:||||||:|.::.|..:|||||:|:|||||.|.|..|||.: ..|||:..|..|.|
Mouse   655 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHR 718

  Fly   653 MEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL--LQTKEDYLDVDI-------ANLDT 708
            |:||:.|:..:|::||.|||.....||.|.::||.:|::  |.:.::|||:.|       :..||
Mouse   719 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSFPDT 783

  Fly   709 PPSTSDEEED 718
            ..||....||
Mouse   784 RSSTCSSGED 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 27/81 (33%)
IG_like 113..191 CDD:214653 26/80 (33%)
IG_like 205..289 CDD:214653 27/95 (28%)
PKc_like 404..692 CDD:304357 162/298 (54%)
STYKc 416..688 CDD:214568 154/280 (55%)
Fgfr1NP_034336.2 Ig1_FGFR 40..118 CDD:143174 19/78 (24%)
IG_like 41..118 CDD:214653 19/77 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..162 13/44 (30%)
I-set 160..247 CDD:254352 29/86 (34%)
Heparin-binding 160..177 4/16 (25%)
Ig2_FGFR 163..247 CDD:143265 27/83 (33%)
IG_like 262..358 CDD:214653 27/95 (28%)
Ig3_FGFR 270..359 CDD:143175 24/88 (27%)
PTKc_FGFR1 464..765 CDD:270678 164/305 (54%)
Pkinase_Tyr 478..754 CDD:285015 154/280 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 782..822 6/12 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 321 1.000 Domainoid score I1221
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 477 1.000 Inparanoid score I1461
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50158
OrthoDB 1 1.010 - - D119660at33208
OrthoFinder 1 1.000 - - FOG0000923
OrthoInspector 1 1.000 - - mtm8830
orthoMCL 1 0.900 - - OOG6_100013
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6544
SonicParanoid 1 1.000 - - X537
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.770

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