Protein Alignment htl and Flt3

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001402681.1
• Gene: Flt3 / 140635
• RGDID: 61308
• Length: 1000
• Species: Rattus norvegicus
• Alignment Length: 916
• Identity: 244/916 - (26%)
• Similarity: 347/916 - (37%)
• Gaps: 309/916 - (33%)

  Fly     7 WRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKD--------HLGARSQNKTP 63
            |...||::..               ||...::.||.::.:...:.:        |:.:.:.|.|.
  Rat   105 WVFKHSSLGC---------------QPHFDLQNRRIVSMTILNVTETQAGEYLLHIQSEATNHTV 154

  Fly    64 AITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHAL 128
            ..|.|..                     |..:.|..:|        ||.:.....:||   |.:.
  Rat   155 LFTVNVR---------------------DTQLYVLRRP--------SFRKMENQDALL---CVSE 187

  Fly   129 GNPEPNITW-----YRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQ 188
            |.|||.:.|     :|    |..|..||....:....:.:|...|   ..|...|:||  |..|:
  Rat   188 GVPEPTVEWVVCSSHR----DSCREEGSAVVKKEEKVLHELFETD---IRCCARNALG--RECTK 243

  Fly   189 VIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLS---------DLTSKKAWIFVPCHG----M 240
            :...| :|..| ..|.| .|.|.|.....:.||.:.         :|.:|     |...|    |
  Rat   244 LFTID-LNQAP-QSTLP-QLFLKVGEPLWIRCKAIHVNHGFGLTWELGNK-----VLEEGSYFEM 300

  Fly   241 TNCSNNRSIIAEDKDQLDFV-NVRMEQEGWYTCVESNSLGQS-----------NST--------- 284
            ::.|.|||:|   :..|.|| :|.....|:|||..|....|:           |:|
  Rat   301 SSYSTNRSMI---RILLAFVSSVGRNNTGYYTCSSSKHPSQTALVTILEKGFINATSSQEEYEID 362

  Fly   285 ------------AYLRV-------VRSLHVLEAGVASGSLHSTSFV---------YIFVFGGLIF 321
                        ||.::       ..|....::|:..|  :|.|..         ||| .|....
  Rat   363 PYEKFCFSVRFKAYPQIRCKWTFSQTSFPCEQSGLEDG--YSISKFCDHKNNPGEYIF-HGENDD 424

  Fly   322 IFMTTLFVFYAIRKMKHEKVL-------------------------------------------K 343
            ...|.:|:....||   .:||                                           |
  Rat   425 AQFTKMFILNIRRK---PQVLANASASQASCFSDGYPLPNWTWKKCSDKSPNCTEEIPEGVWNKK 486

  Fly   344 QRIETVHQWTKKVIIFKPEGGG---------DSSG-SMDTMIM----PVVRIQK----------- 383
            ...:...||.....:...|.|.         :|.| |.:|:::    |.:.||.
  Rat   487 ANRKVFGQWVSSSTLNMSEAGRGFLVKCCAYNSMGTSCETILLNSPGPFLFIQDNISFYATIGLC 551

  Fly   384 ----------------------------QRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGA 420
                                        |.|..|.|......|.:||:  |..||.||.:|..|.
  Rat   552 PPFIVVLTVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYIDFRDYEY--DLKWEFPRENLEFGK 614

  Fly   421 TLGEGAFGRVVMAEVN-------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478
            .||.||||||:.|...       :..|||||:||.....:..:|:.|:::|..:|.|.||:||||
  Rat   615 VLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLG 679

  Fly   479 CCSQNGPLYVIVEYAPHGNLKDFL-YKNRPFGRD----------------QDRDSSQPPPS---- 522
            .|:.:||:|:|.||..||:|.::| .|...|.|.                |...:|..|.|
  Rat   680 ACTLSGPVYLIFEYCCHGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHSNSSMPGSREVQ 744

  Fly   523 --PPA---------------------------------HVITEKDLIKFAHQIARGMDYLASRRC 552
              ||.                                 :|:|.:||:.||:|:|:||::|..:.|
  Rat   745 IYPPVDQVSGFNGNSIHSEDEIEYENQKRLEEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSC 809

  Fly   553 IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVW 617
            :|||||||||||:...|:||.||||||||.|...|....|.|||:||||||||.|..|..|||||
  Rat   810 VHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVW 874

  Fly   618 SYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFT 682
            |||||||||.:.|..|||.|......|..:.||.:||:|...:..||.:|:.||.|::..||.|.
  Rat   875 SYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRPSFP 939

  Fly   683 EIVEYM 688
            .:..::
  Rat   940 NLTSFL 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/94 (26%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	1/8 (13%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	31/134 (23%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	3/4 (75%)
		Ig strand G	282..285	CDD:409353	2/23 (9%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	138/348 (40%)
Flt3	NP_001402681.1	ig	255..345	CDD:395002	27/98 (28%)
		Protein Kinases, catalytic domain	572..949	CDD:473864	145/376 (39%)