Protein Alignment htl and Epha5

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_006534832.1
• Gene: Epha5 / 13839
• MGIID: 99654
• Length: 1040
• Species: Mus musculus
• Alignment Length: 733
• Identity: 171/733 - (23%)
• Similarity: 284/733 - (38%)
• Gaps: 213/733 - (29%)

  Fly    60 NKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWR---NPKKMSFLQTRPSGSLL 121
            :|.|..:....::|||.                    |..|.|:|   :|..|:.  |||..
Mouse   322 SKCPPHSYTHEEASTSC--------------------VCEKDYFRKDSDPPTMAC--TRPPS--- 361

  Fly   122 TLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGN-------YTCKVCNS 179
                 |..|...|:                   |..::.:|.:.|.|.|.       ..||.|||
Mouse   362 -----APRNAISNV-------------------NETSVFLEWIPPADTGGRKDVSYYIACKKCNS 402

  Fly   180 L--------GCIRH--------DTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTS 228
            .        |.:|:        :|.|::.|.:.|        .|.|..:.:...     :||| |
Mouse   403 HAGVCEECGGHVRYLPQQIGLKNTSVMMVDLLAH--------TNYTFEIEAVNG-----VSDL-S 453

  Fly   229 KKAWIFVPCHGMTN---------------CSNNRSIIAEDKDQLDFVNVRME-------QEGWYT 271
            .....:|..:..||               ..|:.|:..::.|:.:.:.:..|       ||..||
Mouse   454 PGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYT 518

  Fly   272 CVESNSL-----GQSNSTAYLRVVRSLHVLEAGV---------------ASGSLHSTSFVYIFVF 316
            .::|...     |...::.|:..:|:......||               ||........:.:.|.
Mouse   519 IIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVSVAASNDQSQIPIIAVSVT 583

  Fly   317 GGLIFIFMTTLFVF------------YAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSG 369
            .|:|.:.:...|:.            .::..:.|..::         |.          .|.|..
Mouse   584 VGVILLAVMIGFLLSGSCCDCGCGRASSLCAVAHPSLI---------WR----------CGYSKA 629

  Fly   370 SMDTMIMPVVRIQKQRTTVLQNGNEPAPF-------NEYEFPLDSNWELPR----SHLVLGATLG 423
            ..|         .::......||:...|.       :.||.|..:..|..:    |.:.:...:|
Mouse   630 KQD---------PEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIG 685

  Fly   424 EGAFGRVVMAEV-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCCS 481
            .|.||.|....:     ....||:|.:|.|:|:......:.|..:|   |:  |.|||:|.|..:
Mouse   686 AGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIM---GQFDHPNIIHLEGVVT 747

  Fly   482 QNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546
            ::.|:.::.||..:|:|..||.||         |..          .|...|:.....||.||.|
Mouse   748 KSKPVMIVTEYMENGSLDTFLKKN---------DGQ----------FTVIQLVGMLRGIAAGMKY 793

  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT-NGRLPIKWMAPESLQEKFY 610
            |:....:||||||||:|::.:.|.|::||||:|.::........| .|::||:|.|||::..:.:
Mouse   794 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKF 858

  Fly   611 DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNA 675
            .|.||||||||::||:::||::|| ..|:.:::...:..|.|:..|..|...:|.||..||..:.
Mouse   859 TSSSDVWSYGIVMWEVVSYGERPY-WEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDR 922

  Fly   676 DDRPPFTEIVEYMDKLLQ 693
            :.||.|.|||..:|||::
Mouse   923 NSRPKFDEIVNMLDKLIR 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/115 (21%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	1/11 (9%)
		Ig strand G	184..187	CDD:409353	1/10 (10%)
		Ig	200..289	CDD:472250	20/115 (17%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	98/299 (33%)
Epha5	XP_006534832.1	EphR_LBD	62..234	CDD:470656
		FN3	<357..>600	CDD:442628	51/283 (18%)
		FN3	471..561	CDD:238020	14/89 (16%)
		EphA2_TM	578..675	CDD:464211	16/124 (13%)
		PTKc_EphR_A	673..939	CDD:270651	96/288 (33%)
		SAM_EPH-A5	968..1033	CDD:188945