DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Epha3

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_034270.1 Gene:Epha3 / 13837 MGIID:99612 Length:984 Species:Mus musculus


Alignment Length:732 Identity:176/732 - (24%)
Similarity:285/732 - (38%) Gaps:209/732 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 ITNNANQSSTS---SADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCH 126
            :.:|.|::|..   |..||.|      .:.|:..|:..|....|.:     |..|        | 
Mouse   332 VISNINETSVILDWSWPLDTG------GRKDITFNIICKKCGWNVR-----QCEP--------C- 376

  Fly   127 ALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIV 191
                 .||:.:...          .|.....|:|:.||:...  |||.::               
Mouse   377 -----SPNVRFLPR----------QLGLTNTTVTVTDLLAHT--NYTFEI--------------- 409

  Fly   192 SDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMT-----NCSNNRSIIA 251
             |.||....|.:.|.....|             .:|:.:|   .|...||     ...|:.|:..
Mouse   410 -DAVNGVSELSSPPRQYAAV-------------SITTNQA---APSPVMTIKKDRTSRNSISLSW 457

  Fly   252 EDKDQ-----LDF---VNVRMEQEGWYTCVESNSLGQSNS-----TAYLRVVRSLHVLEAGVASG 303
            ::.:.     ||:   ...:.|||..||.:.:.....:.|     |.|:..:|:......|..|.
Mouse   458 QEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTTYVFQIRARTAAGYGTNSR 522

  Fly   304 SLH------------STSFVYIFVFGGLIFIFMTTLFVFYAI------RKMKHEKVLKQRIETVH 350
            ...            ..|.|.:......:.|.:.|:..:..:      .|.||....|:    :|
Mouse   523 KFEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGRFCGYHKSKHSAEEKR----LH 583

  Fly   351 QWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDS----NWEL 411
                       .|.|.            :::...||.|     :|   :.||.|..:    ..||
Mouse   584 -----------FGNGH------------LKLPGLRTYV-----DP---HTYEDPTQAVHEFAKEL 617

  Fly   412 PRSHLVLGATLGEGAF-----GRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR-- 469
            ..:::.:...:|.|.|     ||:.:.......||:|.:|.|:|:......:.|..:|   |:  
Mouse   618 DATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIM---GQFD 679

  Fly   470 HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLI 534
            |.|||.|.|..:::.|:.::.||..:|:|..||.|:         |:.          .|...|:
Mouse   680 HPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH---------DAQ----------FTVIQLV 725

  Fly   535 KFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT-NGRLPIK 598
            .....||.||.||:....:||||||||:|::.:.|.|::||||:|.::........| .|::||:
Mouse   726 GMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIR 790

  Fly   599 WMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNI 663
            |.:||::..:.:.|.||||||||:|||:|:||::|| ..||.:::...:..|.|:..|..|...:
Mouse   791 WTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPY-WEMSNQDVIKAVDEGYRLPPPMDCPAAL 854

  Fly   664 YILMRQCWHFNADDRPPFTEIVEYMDKLLQTKE-----------------DYLDVDIANLDTPPS 711
            |.||..||..:.::||.|.:||..:|||::...                 |..:||||...|   
Mouse   855 YQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIATFHT--- 916

  Fly   712 TSDEEEDETDNLQKWCN 728
            |.|           |.|
Mouse   917 TGD-----------WLN 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 14/89 (16%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 3/4 (75%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 20/106 (19%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 1/8 (13%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/7 (14%)
Protein Kinases, catalytic domain 404..692 CDD:473864 98/299 (33%)
Epha3NP_034270.1 EphR_LBD_A3 29..201 CDD:198449
FN3 <323..>516 CDD:442628 48/252 (19%)
FN3 437..528 CDD:238020 18/90 (20%)
EphA2_TM <566..619 CDD:464211 16/87 (18%)
PTKc_EphR_A 617..883 CDD:270651 96/288 (33%)
SAM_EPH-A3 913..975 CDD:188943 5/24 (21%)
PDZ-binding. /evidence=ECO:0000255 982..984
Blue background indicates that the domain is not in the aligned region.

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