DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Epha2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_034269.2 Gene:Epha2 / 13836 MGIID:95278 Length:977 Species:Mus musculus


Alignment Length:696 Identity:185/696 - (26%)
Similarity:282/696 - (40%) Gaps:167/696 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 YWRNPK-KMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLV 165
            |:|.|: .:|...|||..:             ||   |....     |.|:....|||      .
Mouse   314 YFRAPEDPLSMSCTRPPSA-------------PN---YLTAI-----GMGAKVELRWT------A 351

  Fly   166 PGDCG-------NYTCKVC--NSLGC------IRHD--------TQVIVSDRVNHKPILMTGPLN 207
            |.|.|       :.||:.|  .|..|      :|:.        |.|.|||...|        :|
Mouse   352 PKDTGGRQDIVYSVTCEQCWPESGECGPCEASVRYSEPPHALTRTSVTVSDLEPH--------MN 408

  Fly   208 LTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDF-----VNVRMEQE 267
            .|..|.:...     :|.|.:.::  |.......|.:....:..||:.....     :.|..:..
Mouse   409 YTFAVEARNG-----VSGLVTSRS--FRTASVSINQTEPPKVRLEDRSTTSLSVTWSIPVSQQSR 466

  Fly   268 GWYTCVESNSLGQSNS-------------------TAYLRVVRSLHVLEAGVASGS-------LH 306
            .|...|.....|.:||                   |.||..|::|  .:.|..:||       |.
Mouse   467 VWKYEVTYRKKGDANSYNVRRTEGFSVTLDDLAPDTTYLVQVQAL--TQEGQGAGSKVHEFQTLS 529

  Fly   307 STSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSM 371
            :.....:.|.|| :.:.:..|.|...:....|.   ::|.....|.::.|...|.|         
Mouse   530 TEGSANMAVIGG-VAVGVVLLLVLAGVGLFIHR---RRRNLRARQSSEDVRFSKSE--------- 581

  Fly   372 DTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFP----LDSNWELPRSHLVLGATLGEGAFGRVVM 432
                    :::..:|.|     :|   :.||.|    |....|:..|.:.....:|.|.||.|..
Mouse   582 --------QLKPLKTYV-----DP---HTYEDPNQAVLKFTTEIHPSCVARQKVIGAGEFGEVYK 630

  Fly   433 AEVNNAI------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVE 491
            ..:..:.      ||:|.:|.|:|:......:.|..:|.....| |||.|.|..|:..|:.:|.|
Mouse   631 GTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHH-NIIRLEGVVSKYKPMMIITE 694

  Fly   492 YAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRD 556
            |..:|.|..||       |::|.:.|         |:   .|:.....||.||.|||:...:|||
Mouse   695 YMENGALDKFL-------REKDGEFS---------VL---QLVGMLRGIASGMKYLANMNYVHRD 740

  Fly   557 LAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTN-GRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            |||||:||:.:.|.|::||||:|.::........|: |::||:|.|||::..:.:.|.|||||||
Mouse   741 LAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYG 805

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
            |::||:||||::|| ..:|..|:...:..|.|:..|..|...||.||.|||......||.|.:||
Mouse   806 IVMWEVMTYGERPY-WELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIV 869

  Fly   686 EYMDKLLQTKEDYLDVDIANLDTP-----PSTSDEEEDETDNLQKW 726
            ..:|||::..:..  ..:|:.|..     ||||..|......:.:|
Mouse   870 SILDKLIRAPDSL--KTLADFDPRVSIRLPSTSGSEGVPFRTVSEW 913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 26/112 (23%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/10 (10%)
Ig 200..289 CDD:472250 18/112 (16%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 2/21 (10%)
Protein Kinases, catalytic domain 404..692 CDD:473864 106/298 (36%)
Epha2NP_034269.2 Mediates interaction with CLDN4. /evidence=ECO:0000250 1..205
EphR_LBD_A2 27..200 CDD:198448
fn3 331..425 CDD:394996 28/133 (21%)
fn3 439..520 CDD:394996 14/82 (17%)
EphA2_TM <570..611 CDD:464211 12/65 (18%)
Mediates interaction with ARHGEF16. /evidence=ECO:0000250 607..907 112/322 (35%)
Protein Kinases, catalytic domain 608..876 CDD:473864 104/288 (36%)
Negatively regulates interaction with ARHGEF16. /evidence=ECO:0000250 887..977 7/27 (26%)
SAM_EPH-A2 903..972 CDD:188942 2/11 (18%)
PDZ-binding. /evidence=ECO:0000255 975..977
Blue background indicates that the domain is not in the aligned region.

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