DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Csf1r

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001032948.2 Gene:Csf1r / 12978 MGIID:1339758 Length:977 Species:Mus musculus


Alignment Length:777 Identity:214/777 - (27%)
Similarity:318/777 - (40%) Gaps:210/777 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 STSSADLDDG------AADDDDNK-ADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGN 130
            |.::.|..|.      |::|...: |.:...|....|.....:.|.||....|..|.|..||  :
Mouse   264 SLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHA--D 326

  Fly   131 PEPNITWYRNGTVDWTRGY----------------GSLKRNRWTLTMEDLVPGDCGNYTCKVCNS 179
            ..|:|..|     :||  |                .::.|..:.|.:..:...:.|.|.....|.
Mouse   327 AYPSIQHY-----NWT--YLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNK 384

  Fly   180 LG--------CIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVP 236
            .|        .:|:..:|.|:                .:.||.:..:.|...........|  :.
Mouse   385 AGWNNLTFELTLRYPPEVSVT----------------WMPVNGSDVLFCDVSGYPQPSVTW--ME 431

  Fly   237 CHGMTN-CSNNRSIIA------EDKDQLDFVNV---------RMEQEGWYTCVESNSLGQSNSTA 285
            |.|.|: |...:::..      |...|..|..|         .::....|.|...||:|  ||:.
Mouse   432 CRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVG--NSSQ 494

  Fly   286 YLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVH 350
            |.|.| ||.      .|..|...|.....|...:..:.:..|.:...:.|.|.:...:.|.:.:.
Mouse   495 YFRAV-SLG------QSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIE 552

  Fly   351 QWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSH 415
            ::               .|:..|.|.|.                ..|:||       .||.||::
Mouse   553 RY---------------EGNSYTFIDPT----------------QLPYNE-------KWEFPRNN 579

  Fly   416 LVLGATLGEGAFGRVVMAEV-----NNAI--VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINI 473
            |..|.|||.||||:||.|..     .:|:  |||||:|.....|:..:|:.|:::|..:|:|.||
Mouse   580 LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENI 644

  Fly   474 INLLGCCSQNGPLYVIVEYAPHGNLKDFL-----------------------YKN---------- 505
            :||||.|:..||:.||.||..:|:|.:||                       |||          
Mouse   645 VNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRR 709

  Fly   506 ---------------RP---------FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546
                           ||         |.:|.|:::|:|        :...||:.|:.|:|:||.:
Mouse   710 DSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRP--------LELWDLLHFSSQVAQGMAF 766

  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611
            |||:.|||||:||||||::..:|.||.||||||||.:...|....|.|||:|||||||:.:..|.
Mouse   767 LASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYT 831

  Fly   612 SKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNAD 676
            .:|||||||||||||.:.|..|||.|:...:.|..:..|.:|.:|.....|||.:|:.||.....
Mouse   832 VQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPT 896

  Fly   677 DRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTP---------------PSTSDEEEDETDNL 723
            .||.|.:|...:.:  |.:.:..|.|.|||.:.               .|:..|||..:::|
Mouse   897 RRPTFQQICFLLQE--QARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHL 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 23/113 (20%)
Ig strand B 121..125 CDD:409353 2/3 (67%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 20/104 (19%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 2/2 (100%)
Protein Kinases, catalytic domain 404..692 CDD:473864 133/351 (38%)
Csf1rNP_001032948.2 IG_like 28..101 CDD:214653
Ig strand B 38..42 CDD:409353
Ig strand E 67..71 CDD:409353
Ig strand F 81..86 CDD:409353
IG_like 113..195 CDD:214653
Ig 203..295 CDD:472250 6/30 (20%)
Ig strand B 220..224 CDD:409353
Ig strand C 234..238 CDD:409353
Ig strand E 259..263 CDD:409353
Ig strand F 275..280 CDD:409353 0/4 (0%)
Ig strand G 288..291 CDD:409353 1/2 (50%)
Ig 299..398 CDD:472250 21/107 (20%)
Ig strand B 319..323 CDD:409353 2/3 (67%)
Ig strand C 333..337 CDD:409353 1/8 (13%)
Ig strand E 362..366 CDD:409353 1/3 (33%)
Ig strand F 376..381 CDD:409353 1/4 (25%)
Ig strand G 389..392 CDD:409353 0/2 (0%)
Ig_3 399..487 CDD:464046 16/105 (15%)
Regulatory juxtamembrane domain. /evidence=ECO:0000250 540..572 8/69 (12%)
PTKc_CSF-1R 541..913 CDD:133237 142/419 (34%)
Activation loop. /evidence=ECO:0000250 794..816 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 921..957 8/36 (22%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.