Protein Alignment htl and LOC1279581

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_061512028.1
• Gene: LOC1279581 / 1279581
• VectorBaseID: AGAMI1_009797
• Length: 872
• Species: Anopheles gambiae
• Alignment Length: 843
• Identity: 208/843 - (24%)
• Similarity: 331/843 - (39%)
• Gaps: 285/843 - (33%)

  Fly    14 ITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSAD 78
            |.:|:..|:|.:.|.:.        .:.:|..:..:...:||.|..      |||         |
Mosquito   165 IKITTNQLIVSWTLGTF--------NKTEMPENVNLKAIYLGVRRG------TNN---------D 206

  Fly    79 LDDGAADDDDNKADLPVNVSSKPYWRN----PKKMSFLQTRPSGSLLTLNCHALGNP-------- 131
            |..|.......:..|||..::..:..|    .|.:..:|.:   .:.|.:|.....|
Mosquito   207 LAWGGQHSSMREIMLPVESNTHSFNINDFIGSKYIFVVQLK---VIDTRDCERTAQPILVSLPDA 268

  Fly   132 ---EPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNS----------LGCI 183
               .||.|....||                          |.|.|  |||.          |||.
Mosquito   269 EKRLPNATGGSKGT--------------------------CTNDT--VCNCERLNRFPDFLLGCR 305

  Fly   184 RHDTQVIVSDRVNHKPILMTGP-----LNLTLVVNS--TGSMHCKYLSDLTSKKAWIFVPCHGMT 241
            ...:::||:.| ..||:....|     :.|.|.:.|  ||::.|....|..:.....|
Mosquito   306 HEGSEIIVTWR-TLKPVTWRQPSSTDIVQLQLAIRSELTGAILCSVSVDPMATNTHTF------- 362

  Fly   242 NCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASG--- 303
                             ||               :.:..::||::        ||.|....|
Mosquito   363 -----------------FV---------------DEIVPTSSTSF--------VLTASFIDGNNY 387

  Fly   304 ------------SLHSTSF----VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQW 352
                        :|.|||.    :.:.|....:.:..:.||::|           |:|  |..:|
Mosquito   388 CERIIPTYKIPPNLTSTSILVPVICVLVAVITVTVLASILFIYY-----------KRR--TKFRW 439

  Fly   353 T----KKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTV---LQNGNEPAPFNEYEFPLDSNW- 409
            .    :.|.:   ...||..        |.|.:::.|..:   :.|.....         |:::
Mosquito   440 KANNWRGVYV---RSSGDHH--------PQVAMEENRLYIDMDILNARARG---------DADYL 484

  Fly   410 ELPRSHLVLGATLGEGAFGRVVMAEV-------NNAIVAVKMVKEGHTDDDIASLVREMEVMKII 467
            |:|.|.|.:|..:|:||||||.||..       ...|||:|.:|:..:.|:....:.|:.:||.:
Mosquito   485 EVPHSCLRIGREIGKGAFGRVFMASAIKLPGFSGPKIVAIKQLKKCSSSDEFDEFLDEITMMKKV 549

  Fly   468 GRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYK---------------------------- 504
            |:|.||:.|||||:...||.:|:||...|:|.::|.|
Mosquito   550 GKHPNIVALLGCCTIKEPLTMIMEYVGCGDLLEYLRKIRAKHLAKVHQLDIGAQLENANSGLNTA 614

  Fly   505 --NRPFG--------------------------------------------RDQDRDSSQPPPSP 523
              |..||                                            .|:|.:|:....|
Mosquito   615 PGNNIFGPMVKYLDLLHTSSSNSDASYITQTDTTTRPSVTETTYTALSGTMGDEDNNSTIGSCS- 678

  Fly   524 PAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYR 588
            ..:|:..|:|..||.|||.||::|......||||||||:|:.:...|||:||||:|    |..|.
Mosquito   679 LEYVLDHKELHNFAKQIAFGMEHLEGLHITHRDLAARNILIDERKTLKISDFGLSR----TGIYV 739

  Fly   589 KNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRM 653
            ...|.::|::|::.|::::..|.:|||||::||:||||.|.|..|||:: |..||:.||..|:|:
Mosquito   740 NTRNKKVPLRWLSIEAMRDNLYSNKSDVWAFGIVLWEIGTLGGYPYPSV-SNHELFAYLQEGKRL 803

  Fly   654 EKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDV-DIANLDTPPSTSDE 715
            |:|..|::::|.||.|||..:.::||.|.:|.::   |...|:.|:|. :|......|.|||:
Mosquito   804 ERPENCTVDVYDLMLQCWREDPNERPSFQQISKH---LQPHKKIYIDFNEIEPTYVFPPTSDQ 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	20/114 (18%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	2/3 (67%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	13/95 (14%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	120/369 (33%)
LOC1279581	XP_061512028.1	None