Protein Alignment htl and Csk

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_061501935.1
• Gene: Csk / 1278803
• VectorBaseID: AGAMI1_000696
• Length: 1254
• Species: Anopheles gambiae
• Alignment Length: 712
• Identity: 193/712 - (27%)
• Similarity: 287/712 - (40%)
• Gaps: 198/712 - (27%)

  Fly    27 LLSIWQPAVQVEGRR--QMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDN 89
            |.||..|..|:...:  |....|..|..|...  |:..|...|..:....:||.|.
Mosquito   670 LSSIHHPVQQLVAPQSAQQQPHQPPIPPHPAV--QHHIPKSPNQHHPPQPASAVLQ--------- 723

  Fly    90 KADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCH---------ALGNPEPNITWYRNGTVDW 145
                          .||:..|.:    .|.:||.|.|         |.|.|...:|
Mosquito   724 --------------HNPQAASAV----GGGVLTNNSHHTTGPPSTGAGGPPVAPVT--------- 761

  Fly   146 TRGYGSLKRNRWTLTMED-------LVPGDCGNYTCKVCNSLGCIRHDTQ--------VIVSDRV 195
                ||...|..:.:|..       |.|  .|..|    .|...|....|        |..:..|
Mosquito   762 ----GSAAANMMSTSMNSAQLQGHILQP--VGGLT----GSALSIHQQQQQQQQQSAMVQGNQPV 816

  Fly   196 NHKPILMTGPLNLTLVV---------NSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIA 251
            :|....:.||:.|..||         |..|.          ....|..||. |:::.:.:.:..|
Mosquito   817 HHMSNSLHGPIGLPTVVVPPAGHDGSNGVGG----------PAPGWNCVPV-GLSSPTTSAAAAA 870

  Fly   252 EDKDQLDFVNVRMEQEGWY----TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVY 312
            :.:.:   ||.::....|:    ...|:.||.:..... |.:||              .||:|..
Mosquito   871 QRRAE---VNAKLNAMPWFHGRIKREEAESLLKPREDG-LFLVR--------------ESTNFPG 917

  Fly   313 IFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG-----------D 366
            .:           ||.|.:      :|||...||:.|   ..|:.|...|...           |
Mosquito   918 DY-----------TLCVCF------NEKVEHYRIKYV---DNKLTIDDDEYFDHLGQLVEHYTLD 962

  Fly   367 SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEY---EFPLDSNWELPRSHLVLGATLGEGAFG 428
            |.| :.|.:|..:                 |..|:   :|. |:.||:....|.|...:|:|.||
Mosquito   963 SDG-LCTKLMKAL-----------------PKEEFCVKDFQ-DNGWEIKMEDLQLKENIGKGEFG 1008

  Fly   429 RVVMAEVNNAIVAVKMVKE-GHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEY 492
            .|::..:....||||::|: |...:   ..:.|..||..: .|.|::..:|....:..:|::.||
Mosquito  1009 DVMLGIMKGEKVAVKVLKDAGRASN---KFLAEAGVMTTL-EHENLVKFIGLVFHDKYIYLVTEY 1069

  Fly   493 APHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDL 557
            ...|:|.|:|   |..||..               |:.||.|.||:....||:||.:::.|||||
Mosquito  1070 MSKGSLVDYL---RSRGRQH---------------ISRKDQINFAYDTCCGMEYLETKKVIHRDL 1116

  Fly   558 AARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGIL 622
            ||||||:|:|.|.|::|||||||.:.|     ..:.:|||||.|||:|:|..:.:|:|:||:|||
Mosquito  1117 AARNVLISEDCVAKVSDFGLARDERYT-----GDSSKLPIKWTAPEALKEGKFSNKTDMWSFGIL 1176

  Fly   623 LWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEI 684
            ||||.::|:.|||.|..| ::..::.||.:||.|..|...||.:|||.|....:.||.|.|:
Mosquito  1177 LWEIYSFGRVPYPRIPLA-DVVKHVGSGYKMEAPEGCPPEIYEMMRQAWDLVPEKRPTFAEL 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/113 (21%)
		Ig strand B	121..125	CDD:409353	2/3 (67%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	19/101 (19%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/8 (13%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	108/282 (38%)
Csk	XP_061501935.1	None