Protein Alignment htl and Pvr

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_061518287.1
• Gene: Pvr / 1275672
• VectorBaseID: AGAMI1_005611
• Length: 1480
• Species: Anopheles gambiae
• Alignment Length: 889
• Identity: 226/889 - (25%)
• Similarity: 338/889 - (38%)
• Gaps: 283/889 - (31%)

  Fly    23 VLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDD 87
            :.|:.|    |.::|..|...|:...  ||    :..:.:|||      ||.|||.|..|
Mosquito   507 ISFMFL----PCLEVPWRNCSASRTN--KD----KWDSSSPAI------SSESSARLTPG----- 550

  Fly    88 DNKADLPVNVSSKPYWRNPKKMSFLQTRPS----------------------------------G 118
             .|.:.|: ..|:.|...||:...:..|.:                                  |
Mosquito   551 -GKGETPI-AKSRVYTLTPKQPGVVYCRATNLEGSEITEADLLVSDLSDSVMLEKEQPKEAITVG 613

  Fly   119 SLLTLNCHAL-GNPEPNITWYRNG----TVDWTRGYGSLKRNRW--TLTMEDLVPGDCGNYTCKV 176
            ..:|:.|.|| .|....||:..|.    ..|..|...|.:...|  .|.:..:.....|...|:.
Mosquito   614 DHVTIVCSALVYNYTKEITFVHNDKELQESDGVRHDYSAELYAWQARLDIAHVATEHEGPIYCRA 678

  Fly   177 CNSLGCIRHDTQVIVSDRVNH-------KPILMTGPLN--LTLVVNSTGSMHCKYLSDLTSKKAW 232
            ....|.        |..|..|       .|:|::|..|  |::.::....:.|..:.....|..|
Mosquito   679 KTMTGA--------VESRAFHVEVLEPVAPMLVSGKSNESLSVDLHDPLKLECDIVGTPDPKIVW 735

  Fly   233 I--FVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRV-VRSLH 294
            :  ..|.....|  :||  :...|..|.|..::.:..|.:.|...|.:|....  |.:| ||:..
Mosquito   736 LKDGEPVRPDEN--SNR--VQLTKTTLIFEYLKTDDLGMFECRAENKMGTIEK--YWKVDVRTAV 794

  Fly   295 VLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIF 359
            |.:           |.:||.:...|:.|....|...:..||.|..|.:|: ...|:.....:.::
Mosquito   795 VRK-----------SVIYIILSLLLVLIVGIVLVSMFYCRKKKEVKAMKE-AGIVNFEEGNLGVY 847

  Fly   360 KPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGE 424
            .||...|....:                               .|.:|.:|.|:..|.||..||.
Mosquito   848 NPELALDEQADL-------------------------------LPYNSEYEFPKERLKLGKQLGT 881

  Fly   425 GAFGRV-------VMAEVNNAIVAVKMVKEGHTDDDI-ASLVREMEVMKIIGRHINIINLLGCCS 481
            ||||.|       :|...:...|||||||: .||::: .:||.|:::|..:|:|:|::||||..:
Mosquito   882 GAFGVVMKATAQRIMVNEDETTVAVKMVKK-QTDNEVMRALVSELKIMVHLGQHLNVVNLLGAVT 945

  Fly   482 QN---GPLYVIVEYAPHGNLKDFLYKNRPFGRDQ------DRDSS-------------------- 517
            :|   ..|.|||||...||:::||.|:||...||      :.|||
Mosquito   946 KNIAKRELMVIVEYCRFGNVQNFLLKHRPHFIDQINQETGEIDSSIDKNQLRWSKCGYQYNSQGL 1010

  Fly   518 --------------QPPPSP--------------------------------------------- 523
                          .|...|
Mosquito  1011 KYVNLSFSTNNVNHHPLQHPTAFYHNNHIDSGSTQYVDPKKHLNSKGYVRHSGLQNMGMVDSCNT 1075

  Fly   524 ---------------------------------PAHVITEKDLIKFAHQIARGMDYLASRRCIHR 555
                                             ||..:...||:.:|.|||.||:|||||:.:|.
Mosquito  1076 EVTAMTSVEVEDLNSVNSNEPLWRSNYGMDYKGPARTVNTTDLVCWASQIACGMEYLASRKVLHG 1140

  Fly   556 DLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            ||||||:|:.||.|:||.||||||.:..:|.|:|.....||.||:|.|.:.:..:.:.||||:||
Mosquito  1141 DLAARNILLCDDNVVKICDFGLARSMYKSDNYKKKGEAPLPFKWLALECIGDNVFSTYSDVWAYG 1205

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
            |:|||:.:.|:.|||.:.:.:|||..|..|.||:||...:.:||.:|..||:...|.||.|.::.
Mosquito  1206 IVLWELFSLGKVPYPGMEANQELYNKLRDGYRMDKPQYSNQDIYDIMLNCWNVKPDSRPSFKDLK 1270

  Fly   686 ---------EYMDKLLQTKEDYL----------DVD-IANLDTP 709
                     :..|..|:..|.||          |.| :|||..|
Mosquito  1271 SRFNAMLPDDMRDHYLELNEPYLQMNAEKMERGDTDYLANLGPP 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	21/130 (16%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	2/3 (67%)
		Ig strand E	157..161	CDD:409353	2/5 (40%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	19/92 (21%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	132/425 (31%)
Pvr	XP_061518287.1	None