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Protein Alignment htl and Alk

DIOPT Version :10

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_031465.2	Gene:	Alk / 11682	MGIID:	103305	Length:	1621	Species:	Mus musculus

Alignment Length:	646	Identity:	162/646 - (25%)
Similarity:	259/646 - (40%)	Gaps:	183/646 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 WYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKV-------------------CNSLG- 181
            |..|.::.|..              :.|:.|..|.::|..                   |:|.|
Mouse   887 WNDNTSLLWAG--------------KSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGG 937

  Fly   182 ---------CIRHDTQVIVSDRVN--------HKPILMT----GPLNLTLVVNSTGSMHCKY--- 222
                     ...:|.::...|.|:        :.|.|..    |.:|:...:|.:   ||:.
Mouse   938 GGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCS---HCEVDEC 999

  Fly   223 LSDLTSKKAWIFVPC-HGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAY 286
            ..|..|.|...|  | ||        :::|:|               ..:|:.|     .....:
Mouse  1000 HMDPESHKVICF--CDHG--------TVLADD---------------GVSCIVS-----PTPEPH 1034

  Fly   287 LRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQ 351
            |.:...|.|:.:.:.:        ..:..|.|::.::           :.||:::...::|
Mouse  1035 LPLSLILSVVTSALVA--------ALVLAFSGIMIVY-----------RRKHQELQAMQME---- 1076

  Fly   352 WTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEF-----PLDSNWEL 411
                                  :..|..::.|.||:.:.....|    .|.|     .:....|:
Mouse  1077 ----------------------LQSPEYKLSKLRTSTIMTDYNP----NYCFAGKTSSISDLKEV 1115

  Fly   412 PRSHLVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEGHTD-DDIASLVREMEVMKIIG 468
            ||.::.|...||.||||.|...:|:.       ..||||.:.|..:: |::..|:..:.:.|.
Mouse  1116 PRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF-- 1178

  Fly   469 RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDL 533
            .|.||:..:|...|..|.::::|....|:||.||.:.|            |.|:.|.. :...||
Mouse  1179 NHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETR------------PRPNQPTS-LAMLDL 1230

  Fly   534 IKFAHQIARGMDYLASRRCIHRDLAARNVLVS---DDYVLKIADFGLARDIQSTDYYRKNTNGRL 595
            :..|..||.|..||.....||||:||||.|::   ...:.||.|||:||||....||||.....|
Mouse  1231 LHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAML 1295

  Fly   596 PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660
            |:|||.||:..|..:.||:|.||:|:|||||.:.|..|||: .|.:|:..::.||.||:.|..|.
Mouse  1296 PVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCP 1359

  Fly   661 MNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTP----PSTSDEEE 717
            ..:|.:|.|||....:|||.|..|:|.::...|      |.|:.|...|    |...:||:
Mouse  1360 GPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQ------DPDVINTALPIEYGPVVEEEEK 1414

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.