DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_473412.1	Gene:	Fgfrl1 / 116701	MGIID:	2150920	Length:	529	Species:	Mus musculus

Alignment Length:	299	Identity:	84/299 - (28%)
Similarity:	129/299 - (43%)	Gaps:	35/299 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKM-SFLQTRPSG 118
            |:.|.|.|..|.::.:....|     .|.......:.|......::|.:..|.|| ..:..||.|
Mouse   102 GSLSVNYTLIIMDDISPGKES-----PGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVG 161

  Fly   119 SLLTLNCHALGNPEPNITWYRNGTVDWTRGY---GSLKRNRWTLTMEDLVPGDCGNYTCKVCNSL 180
            |.:.|.|.|.|:|.|:|.|.::   |.|..:   ...::.:|||::::|.|.|.|.|||:|.|..
Mouse   162 SSVRLKCVASGHPRPDIMWMKD---DQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNKA 223

  Fly   181 GCIRHDTQVIVSDRVNHKPILM-TGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCS 244
            |.|....:|.|..|...||:|. |.|:|.|:....|.|..||..||:.....|:....:|.....
Mouse   224 GAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRH 288

  Fly   245 NNRSIIAEDK------------------DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVR 291
            |:...:...|                  ::|.....|.:..|.|.|:.:|::|.|..:|:|.|:.
Mouse   289 NSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLP 353

  Fly   292 SLHVLEAGVASGSLHSTSFVYIFVFG---GLIFIFMTTL 327
            ........:||.| .|||..:..|.|   |.:||..|.|
Mouse   354 DPKPPGPPMASSS-SSTSLPWPVVIGIPAGAVFILGTVL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	29/81 (36%)
		IG_like	113..191	CDD:214653	29/80 (36%)
		IG_like	205..289	CDD:214653	23/101 (23%)
		PKc_like	404..692	CDD:304357
		STYKc	416..688	CDD:214568
Fgfrl1	NP_473412.1	I-set	29..112	CDD:369462	4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..151		5/39 (13%)
		Ig2_FGFRL1-like	153..234	CDD:143264	29/83 (35%)
		Ig	257..351	CDD:386229	20/93 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900