DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and styk1a

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_005159545.1	Gene:	styk1a / 101886109	ZFINID:	ZDB-GENE-060503-428	Length:	435	Species:	Danio rerio

Alignment Length:	443	Identity:	111/443 - (25%)
Similarity:	188/443 - (42%)	Gaps:	81/443 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 GSLHSTSF--VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVL------KQRIETVHQWTKKVIIF 359
            |||....|  |.:.|...|..:....:.:...:.|..|:|..      |:...|.|.       .
Zfish    14 GSLCEVLFYQVELIVVPVLFLLLFLAIMIILLVLKCSHKKSYRHKHHRKENDHTQHH-------H 71

  Fly   360 KPEG----------GGDSSGSMDTM---IMPVV-----RIQKQRTTVLQNGNE--PAPFNEYEFP 404
            ..:|          |.|:...::.|   ::|:.     .:|...:.:.|...|  |:.| :...|
Zfish    72 NTQGSHRSNRRHLQGIDAPAELNPMEHEVIPMTAQAPHEVQSSASAIPQQTTERHPSSF-QLLSP 135

  Fly   405 LDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR 469
            |..::.:.:.:..|.            .|.::...|.::::||.....:..|.:.....:..:|.
Zfish   136 LPISFSVKQDNFTLH------------RAAIDRQPVILRVLKESANARERQSFLGFSHFLSELGP 188

  Fly   470 HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLI 534
            |.::..|||..|...||.:.||...|.:|..||::.|     ||......|..     :||:.:.
Zfish   189 HESLPKLLGVVSARTPLMMAVEELEHRDLLGFLWRCR-----QDHTGQAAPCD-----MTERRIF 243

  Fly   535 KFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL---- 595
            ....|||..::||.|:.|||.::.||:|||..|..:|:...|.|       |:||:....:
Zfish   244 TMGAQIASALEYLHSKNCIHGNVKARSVLVGQDLSVKLWGLGPA-------YHRKSNASSIEDLE 301

  Fly   596 ---PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPA 657
               ..||.|||.|..:.....|||||:||||:|::|.|:.|:|.|| |.||..:|.....:::|.
Zfish   302 EIETRKWQAPELLARQPLQQSSDVWSFGILLYEMVTLGEAPFPNIM-ASELLQHLQRENTLKRPP 365

  Fly   658 KCSMNIYILMRQCWHFNADDRPPFTEIVEYM--------DKLLQTKEDYLDVD 702
            .||..:|.:|:.|..:.|.||....|::..:        |:.:....:.||::
Zfish   366 NCSNTLYSIMKSCCKWRAKDRVSLAELIRKLQSGERSANDQAVLRVSEPLDIE 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	86/302 (28%)
		STYKc	416..688	CDD:214568	83/278 (30%)
styk1a	XP_005159545.1	PKc_like	158..397	CDD:304357	81/256 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810