Protein Alignment htl and hck

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_005174178.1
• Gene: hck / 101885596
• ZFINID: ZDB-GENE-090313-72
• Length: 499
• Species: Danio rerio
• Alignment Length: 450
• Identity: 136/450 - (30%)
• Similarity: 206/450 - (45%)
• Gaps: 89/450 - (19%)

  Fly   264 MEQEGWY------TCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFI 322
            :|.|.|:      ...|...|...|.|.      |..:.::....|| :|.|
Zfish   112 LETEEWFFKGVSRKDAERQLLASGNKTG------SFMIRDSETTKGS-YSLS------------- 156

  Fly   323 FMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSG-------SMDTMIMPVVR 380
                      :|...|:      .:||..:..:.:        |:.|       :.:|:...|..
Zfish   157 ----------VRDSDHQ------ADTVKHYKIRTL--------DNGGFYISPRITFNTLQDLVSH 197

  Fly   381 IQKQRTTVLQNGNEPAPFNEYEFPLDSN-WELPRSHLVLGATLGEGAFGRVVMAEVN-NAIVAVK 443
            .:||...:.|:...|....:.:.|.:.: ||:||..|.|...||.|.||.|.||..| :..||||
Zfish   198 YKKQSDGLCQSLTSPCLSPKPQKPWEKDAWEIPRESLKLDKRLGAGQFGEVWMAMYNKHTKVAVK 262

  Fly   444 MVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPF 508
            .:|.|..  .:.:.:.|..:||.: :|..::.|....::..|:|:|.|:...|:|.||:
Zfish   263 TMKPGSM--SVEAFLMEANLMKSL-QHDKLVRLNAVVTKEEPIYIITEFMEKGSLLDFI------ 318

  Fly   509 GRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIA 573
             :..:.:..|.|           .||.|:.|||.||.|:..|..|||||.|.|:||:...|.|||
Zfish   319 -KSDEGNRVQLP-----------KLIDFSAQIAEGMAYIEQRNYIHRDLRAANILVNKSLVCKIA 371

  Fly   574 DFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM 638
            ||||||.|:..:|..:. ..:.||||.|||::....:..||||||:||||.||::||:.|||. |
Zfish   372 DFGLARIIEDNEYTARE-GAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPYPG-M 434

  Fly   639 SAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDY 698
            :..|:...|..|.||::...|...:|.:|.:||....:|||.|    ||:..:|   ||:
Zfish   435 TNPEVIRALERGYRMQRLDSCPQELYDIMLECWKNKPEDRPTF----EYLQSVL---EDF 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	7/30 (23%)
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353	1/10 (10%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	109/289 (38%)
hck	XP_005174178.1	SH3	58..109	CDD:473055
		SH2	113..215	CDD:472789	24/145 (17%)
		PTKc_Hck	222..487	CDD:270658	110/294 (37%)