DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and tie1

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_002931650.3 Gene:tie1 / 100496664 XenbaseID:XB-GENE-922217 Length:1127 Species:Xenopus tropicalis


Alignment Length:698 Identity:207/698 - (29%)
Similarity:310/698 - (44%) Gaps:178/698 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 GAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWT 146
            |.|.:|.|...:..|:.|.|...|            |.||.:.     :||.::....|.|..:.
 Frog   544 GHAVEDRNTLYISWNLPSTPVIGN------------GFLLQIY-----HPENHLIRQENITSMYV 591

  Fly   147 ---RGYGSLKRNRWTLTMEDLVPGDCGNYTCKV----CNSLGCIRHDTQVIVSDRVNHKPILMTG 204
               :.|| |..|:              .||.||    |.:||        ..||     |.::| 
 Frog   592 LSRKVYG-LHANK--------------EYTLKVLIYHCRNLG--------PPSD-----PFVVT- 627

  Fly   205 PLNLTLVVNSTG-----SMHCKYLSDLTSKKAWI--FVPCHGMTNCS-NNRSIIAEDKDQLDFVN 261
                   ::|.|     .:..:.:|..:.|.:|:  ..|..|:...: .:|.:....:.|  :.:
 Frog   628 -------IHSKGPSPPKDLRAEPISRDSIKLSWLPPDDPNGGIIKYTVESRPVGIPGEPQ--WAD 683

  Fly   262 VRMEQEGWYTCVESNSLGQSNSTAY---------------LRVVRSLHVLEAGV----------- 300
            ...:.:.|:..     .|.:.||.|               |.|..:.|.||.|.           
 Frog   684 TENQNQTWHII-----SGLNASTFYQFRVRANSKVPGEWSLSVQSTAHSLEIGSQPPSMESKNPR 743

  Fly   301 ASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG 365
            .|||.|.   :.:.:.|.:.....|.:....|:..:|.....::|:.|..           .|.|
 Frog   744 PSGSSHQ---LILAIIGSVSITCFTIILALLALFCIKKNFFHRRRMFTYQ-----------SGSG 794

  Fly   366 D------SSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNE-YEFPLDSNWELPRSHLVLGATLG 423
            :      |||:                  |.....|.|..| :.:|: ..||    .:.....:|
 Frog   795 EETILQFSSGT------------------LTLSRRPRPQTEPFSYPV-LEWE----DIKFEDVIG 836

  Fly   424 EGAFGRVVMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ 482
            ||.||:|:.|.:.      ||  |:||:||..:::|......|:||:..:|.|.|||||||.|..
 Frog   837 EGNFGQVIKAMIKKDGQKMNA--AIKMLKEFASENDHRDFAGELEVLCKLGHHPNIINLLGACEN 899

  Fly   483 NGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAH----VITEKDLIKFAHQIARG 543
            .|.||:.:||||:|||.|||.|:|....|        |.....|    .:|.:.|::||..:|:|
 Frog   900 RGYLYIAIEYAPYGNLLDFLRKSRVLETD--------PVFAKEHGTASTLTSQQLLQFASDVAKG 956

  Fly   544 MDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEK 608
            |.||:.::.||||||||||||.::.|.|||||||:|   ..:.|.|.|.||||::|||.|||...
 Frog   957 MQYLSEKQFIHRDLAARNVLVGENLVTKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYS 1018

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|.:||||||:|:|||||::.|..|| ..|:..|||..|..|.|||||..|...:|.||||||..
 Frog  1019 VYTTKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYENLPQGYRMEKPRNCDDEVYELMRQCWRD 1082

  Fly   674 NADDRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLDTPPSTSDE 715
            ...:||||::|...:.::|..::.|:::.:      |.:|   :|::|
 Frog  1083 RPYERPPFSQISIQLTRMLDARKAYVNMALFENFTYAGID---ATAEE 1127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 18/85 (21%)
IG_like 113..191 CDD:214653 18/84 (21%)
IG_like 205..289 CDD:214653 15/106 (14%)
PKc_like 404..692 CDD:304357 132/297 (44%)
STYKc 416..688 CDD:214568 129/281 (46%)
tie1XP_002931650.3 IG_like 124..203 CDD:214653
EGF_CA <222..247 CDD:238011
EGF_CA 306..336 CDD:238011
Ig 341..432 CDD:416386
Ig strand A 341..345 CDD:409353
Ig strand A' 351..355 CDD:409353
Ig strand B 358..367 CDD:409353
Ig strand C 375..380 CDD:409353
Ig strand C' 384..386 CDD:409353
Ig strand D 390..394 CDD:409353
Ig strand E 397..405 CDD:409353
Ig strand F 413..421 CDD:409353
Ig strand G 424..432 CDD:409353
fn3 448..511 CDD:394996
FN3 633..724 CDD:238020 14/97 (14%)
PTKc_Tie1 826..1122 CDD:270671 134/313 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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